Neuropathology for the Neuroradiologist: Plaques and Tangles

Wippold, Franz J.; Cairns, Nigel J.; Vo, Katie D.; Holtzman, David M.; Morris, John C.

doi:10.3174/ajnr.a0781

Cited by 140 publications

(186 citation statements)

References 47 publications

(76 reference statements)

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“…Glioma cells forming pseudopalisades are typical of high-grade glial tumors, increasingly found around necrotic hotspots. 32 They are in a state of organized migration away from necrotic areas, featuring increased expression of proangiogenic factors, for example, VEGF, HIF1/2, and MMPs. 33 The current findings indicate that COL6A1 may be expressed by this particular class of glioma cells that master the evasion of hostile conditions and are probably at the core of glioma's ability to adapt and survive all therapies available today.…”

Section: ■ Discussionmentioning

confidence: 99%

Accessibilome of Human Glioblastoma: Collagen-VI-alpha-1 Is a New Target and a Marker of Poor Outcome

et al. 2014

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Functional targeted therapy has unfortunately failed to improve the outcome of glioblastoma patients. Success stories evidenced by the use of antibody−drug conjugates in other tumor types are encouraging, but targets specific to glioblastoma and accessible through the bloodstream remain scarce. In the current work, we have identified and characterized novel and accessible proteins using an innovative proteomic approach on six human glioblastomas; the corresponding data have been deposited in the PRIDE database identifier PXD001398. Among several clusters of uniquely expressed proteins, we highlight collagen-VI-alpha-1 (COL6A1) as a highly expressed tumor biomarker with low levels in most normal tissues. Immunohistochemical analysis of glioma samples from 61 patients demonstrated that COL6A1 is a significant and consistent feature of high-grade glioma. Deposits of COL6A1 were evidenced in the perivascular regions of the tumor-associated vasculature and in glioma cells found in pseudopalisade structures. Retrospective analysis of public gene-expression data sets from over 300 glioma patients demonstrated a significant correlation of poor patient outcome and high COL6A1 expression. In a proof-of-concept study, we use chicken chorioallantoic membrane in vivo model to show that COL6A1 is a reachable target for IV-injected antibodies. The present data warrant further development of human COL6A1 antibodies for assessing the quantitative biodistribution in the preclinical tumor models.

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Section: ■ Discussionmentioning

confidence: 99%

Accessibilome of Human Glioblastoma: Collagen-VI-alpha-1 Is a New Target and a Marker of Poor Outcome

et al. 2014

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“…Tumours usually create grey solid masses, but may also present as cystic areas with xanthomatous modifications. Histologically, two different forms may be distinguished according to growth features: Antoni form A is characterised by prolonged bundles of bipolar elements, associated with argyrophilic fibrils with nuclei aligned in parallel termed 'palisades', separated by hyaline bands, also termed Verocay bodies (8,(37)(38)(39)(40); Antoni form B is characterised by polymorphic and frequently astrocyte-like elements, associated with mucus and microcystic degeneration (8,(37)(38)(39)(40). There may be degenerative phenomena, such as fatty degeneration, and vessels may appear as being telangiectatic, sinusoidal or with thickened walls.…”

Section: Imaging and Diagnosismentioning

confidence: 99%

“…Histologically, malign schwannomas appear similarly to fibrosarcoma, being constituted by cells and elongated nuclei that are organised in fascicles. Cells may also form small vortexes and, occasionally, palisades (39). Mitotic events are frequent.…”

Section: Imaging and Diagnosismentioning

confidence: 99%

Schwannoma of the hypoglossal nerve: Review of the literature based on an illustrative case

et al. 2017

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Abstract. Schwannomas are benign tumours that originate from the myelin sheath of peripheral nerves. They are characterised by a slow growth tendency. Benign schwannomas represent 35% of the head and neck district tumours. Hypoglossal schwannomas account for 5% of non-vestibular schwannomas, and malignant schwannomas occur very rarely. In the present case report, the case of a 49-year-old man who presented with paraesthesias in the left parotid and submandibular region, associated with sensation of foreign bodies and dysphagia for solids, is described. A clinical examination revealed the presence of an ovoid palpable mass in the lateral-cervical region of the neck. The patient subsequently underwent excisional surgery, and neuropathological evaluation of the specimen confirmed the diagnosis of benign schwannoma with Antoni areas A and B. Despite the rarity of schwannomas, this condition should be considered in differential diagnoses for masses localised in the neck, as in cases where they reach considerable sizes (>3 cm in diameter). Surgery therefore represents the first-choice treatment.

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“…Tumor cells in highly differentiated retinoblastoma are clustered in a characteristic pattern, called Flexner-Wintersteiner rosettes. 22 An increasing number of rosettes are seen in highly differentiated tumors, with photoreceptor differentiation being the most advanced degree of retinal differentiation found in retinoblastoma (retinocytoma). 23 Highly differentiated tumors, with numerous rosettes and photoreceptor cell differentiation, display a relatively paucicellular cytoarchitecture with respect to poorly differentiated tumors.…”

Section: Parametermentioning

confidence: 99%

Single-Shot Turbo Spin-Echo Diffusion-Weighted Imaging for Retinoblastoma: Initial Experience

Graaf¹,

Pouwels²,

Rodjan

et al. 2011

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Retinoblastoma may exhibit variable hyperintensities on DWI, resulting in different values in the ADC maps, depending on their histology and cellularity. However, EP-based DWI has susceptibility artifacts and image distortions, which make DWI of the orbit a challenging technique. The aim of this study was to investigate the feasibility of single-shot turbo spin-echo (HASTE) DWI in the evaluation of children with retinoblastoma and to assess the value of ADC maps in differentiating viable and necrotic tumor tissue.

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Neuropathology for the Neuroradiologist: Plaques and Tangles

Cited by 140 publications

References 47 publications

Accessibilome of Human Glioblastoma: Collagen-VI-alpha-1 Is a New Target and a Marker of Poor Outcome

Accessibilome of Human Glioblastoma: Collagen-VI-alpha-1 Is a New Target and a Marker of Poor Outcome

Schwannoma of the hypoglossal nerve: Review of the literature based on an illustrative case

Single-Shot Turbo Spin-Echo Diffusion-Weighted Imaging for Retinoblastoma: Initial Experience

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