Neuropathological Correlates of Falling in the CC75C Population-Based Sample of the Older Old

Abstract

Subclinical pathologies sharing a common vascular origin are associated with increased falling amongst people with no dementia, as are microinfarcts in those with dementia. Although further research is needed to address the mechanisms of falls and their neuropathological correlates, the findings from the current study would suggest that if cerebrovascular disease prevention reduces vascular neuropathology changes this may have direct benefits in reducing falls amongst older people with or without dementia.

Editorial (Hot Topic: Epidemiology & Risk Factors for Alzheimer’s Disease)

“…The investigators have managed to accrue well over 400 autopsies. The next article paper gives results from the Cambridge City over-75s Cohort [37]. It began in the mid 1980s and now has more than 200 autopsies.…”