Neuropathological characterisation of French bovine spongiform encephalopathy cases

Debeer, Sabine; Baron, Thierry; Bencsik, Anna

doi:10.1007/s00418-003-0593-5

Cited by 25 publications

(24 citation statements)

References 39 publications

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“…157,178 Outside Great Britain, lesion profiles covering the entire brain were described in BSE cases from France and Switzerland. 56,73 These cases were consistent with the British findings and supported the notion that the disease phenotype was similar, irrespective of its geographical occurrence.…”

Section: Bse In Cattlesupporting

confidence: 89%

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Atypical Transmissible Spongiform Encephalopathies in Ruminants: A Challenge for Disease Surveillance and Control

2010

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Abstract. Since 1987, when bovine spongiform encephalopathy (BSE) emerged as a novel disease in cattle, enormous efforts were undertaken to monitor and control the disease in ruminants worldwide. The driving force was its high economic impact, which resulted from trade restrictions and the loss of consumer confidence in beef products, the latter because BSE turned out to be a fatal zoonosis, causing variant Creutzfeldt-Jakob disease in human beings. The ban on meat and bone meal in livestock feed and the removal of specified risk materials from the food chain were the main measures to successfully prevent infection in cattle and to protect human beings from BSE exposure. However, although BSE is now under control, previously unknown, socalled atypical transmissible spongiform encephalopathies (TSEs) in cattle and small ruminants have been identified by enhanced disease surveillance. This report briefly reviews and summarizes the current level of knowledge on the spectrum of TSEs in cattle and small ruminants and addresses the question of the extent to which such atypical TSEs have an effect on disease surveillance and control strategies.

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Section: Bse In Cattlesupporting

confidence: 89%

“…56,86 More comprehensive case numbers were analyzed systematically at the level of the obex. The target nuclei defined for the histopathologic diagnosis consistently showed distinctive immunolabeling patterns in IHC.…”

Section: Bse In Cattlementioning

confidence: 99%

Atypical Transmissible Spongiform Encephalopathies in Ruminants: A Challenge for Disease Surveillance and Control

2010

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“…In C-BSE cases, PrP Sc has been widely distributed throughout the brain, the highest amounts of PrP Sc being detected in the brainstem and the smallest being seen in the cerebral cortices [5,27,30]. The present study describes the types and distribution of immunolabeled PrP Sc in the central nervous system of 7 confirmed C-BSE cases by the fallen stock surveillance program in Japan.…”

Section: )mentioning

confidence: 87%

Neuroanatomical Distribution of Disease-Associated Prion Protein in Cases of Bovine Spongiform Encephalopathy Detected by Fallen Stock Surveillance in Japan

Okada

Iwamaru

Imamura

et al. 2011

The Journal of Veterinary Medical Science

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ABSTRACT. Bovine spongiform encephalopathy (BSE) is a fatal neurodegenerative disorder of cattle characterized by accumulation of the disease-associated prion protein (PrP Sc ) in the central nervous system (CNS). The immunohistochemical patterns and distribution of PrP Sc were investigated in the CNS, brains, and spinal cords of 7 naturally occurring BSE cases confirmed by the fallen stock surveillance program in Japan. No animals showed characteristic clinical signs of the disease. Coronal slices of 14 different brain areas in each case were immunohistochemically analyzed using an anti-prion protein antibody. Immunolabeled PrP Sc deposition was widely observed throughout each brain and spinal cord. Intense PrP Sc deposition was greater in the thalamus, brainstem, and spinal cord of the gray matter than in the neocortices. The topographical distribution pattern and severity of PrP Sc accumulation were mapped and plotted as immunohistochemical profiles of the different brain areas along the caudal-rostral axis of the brain. The distribution pattern and severity of the immunolabeled PrP Sc in the CNS were almost the same among the 7 cases analyzed, suggesting that the naturally occurring cases in this study were at the preclinical stage of the disease. Immunohistochemical mapping of the PrP Sc deposits will be used to clarify the different stages of BSE in cattle.

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“…This has led to the detection of over 5,000 BSE cases outside the United Kingdom. On the basis of the results available from diagnostic and limited bioassay studies, the cases from this active surveillance are expected to be of the same BSE type as the type detected in the United Kingdom (16,22,37). However, rare variants of BSE have now also been detected as a consequence of this active surveillance in cattle (Bos taurus) (8,14,17,23,45,49,61) and in a miniature zebu (Bos indicus) (53).…”

mentioning

confidence: 94%

Molecular Discrimination of Atypical Bovine Spongiform Encephalopathy Strains from a Geographical Region Spanning a Wide Area in Europe

Jacobs¹,

Langeveld²,

et al. 2007

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Transmissible spongiform encephalopathy strains can be differentiated by their behavior in bioassays and by molecular analyses of the disease-associated prion protein (PrP) in a posttranslationally transformed conformation (PrP Sc ). Until recently, isolates from cases of bovine spongiform encephalopathy (BSE) appeared to be very homogeneous. However, a limited number of atypical BSE isolates have recently been identified upon analyses of the disease-associated proteinase K (PK) resistance-associated moiety of PrP Sc (PrP res ), suggesting the existence of at least two additional BSE PrP res variants. These are defined here as the H type and the L type, according to the higher and lower positions of the nonglycosylated PrP res band in Western blots, respectively, compared to the position of the band in classical BSE (C-type) isolates. These molecular PrP res variants, which originated from six different European countries, were investigated together. In addition to the migration properties and glycosylation profiles (glycoprofiles), the H-and L-type isolates exhibited enhanced PK sensitivities at pH 8 compared to those of the C-type isolates. Moreover, H-type BSE isolates exhibited differences in the binding of antibodies specific for N-and more C-terminal PrP regions and principally contained two aglycosylated PrP res moieties which can both be glycosylated and which is thus indicative of the existence of two PrP res populations or intermediate cleavage sites. These properties appear to be consistent within each BSE type and independent of the geographical origin, suggesting the existence of different BSE strains in cattle. The choice of three antibodies and the application of two pHs during the digestion of brain homogenates provide practical and diverse tools for the discriminative detection of these three molecular BSE types and might assist with the recognition of other variants.

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Neuropathological characterisation of French bovine spongiform encephalopathy cases

Cited by 25 publications

References 39 publications

Atypical Transmissible Spongiform Encephalopathies in Ruminants: A Challenge for Disease Surveillance and Control

Atypical Transmissible Spongiform Encephalopathies in Ruminants: A Challenge for Disease Surveillance and Control

Neuroanatomical Distribution of Disease-Associated Prion Protein in Cases of Bovine Spongiform Encephalopathy Detected by Fallen Stock Surveillance in Japan

Molecular Discrimination of Atypical Bovine Spongiform Encephalopathy Strains from a Geographical Region Spanning a Wide Area in Europe

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