2019
DOI: 10.1093/jnen/nlz047
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Neuropathological Changes in Dementia With Lewy Bodies and the Cingulate Island Sign

Abstract: The cingulate island sign (CIS) refers to the relative sparing of metabolism in the posterior cingulate cortex (PCC) and represents an important biomarker in distinguishing dementia with Lewy bodies (DLB) from Alzheimer disease (AD). The underlying basis of the CIS is unknown; therefore, our aim was to investigate which neurodegenerative changes underpin the formation of CIS. Using quantitative neuropathology, α-synuclein, phosphorylated Tau, and amyloid-β pathology was assessed in 12 DLB, 9 AD and 6 age-match… Show more

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Cited by 17 publications
(12 citation statements)
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“…We emphasize that this analysis was exploratory and requires further comprehensive validation. The cortical susceptible group harbored higher cingulate island ratio and worse visuospatial processing and trended toward greater frequency of hallucinations, all supportive of concomitant LBD 18,19 . In contrast, the limbic susceptible group had the greatest average age among groups (78.9 ± 6.1 years) and a pattern of MTLpredominant hypometabolism with asymmetry, all features that have been associated with LATE 21,22 .…”
Section: Discussionmentioning
confidence: 93%
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“…We emphasize that this analysis was exploratory and requires further comprehensive validation. The cortical susceptible group harbored higher cingulate island ratio and worse visuospatial processing and trended toward greater frequency of hallucinations, all supportive of concomitant LBD 18,19 . In contrast, the limbic susceptible group had the greatest average age among groups (78.9 ± 6.1 years) and a pattern of MTLpredominant hypometabolism with asymmetry, all features that have been associated with LATE 21,22 .…”
Section: Discussionmentioning
confidence: 93%
“…We tested imaging and clinical markers of α-synuclein (Lewy body) pathology in the cortical susceptible group. A well-studied, potential indicator of Lewy Body Disease (LBD) is the cingulate island sign [18][19][20] , the relative sparing of 18 F-FDG SUVR in the posterior cingulate cortex relative to precuneus and cuneus (Fig. 5a).…”
Section: Resultsmentioning
confidence: 99%
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“…At the brain level, Lewy body spectrum disorders (LBSD) such as PD, Parkinson’s disease with dementia (PDD) and DLB are characterized by diffuse brain lesions related to the progression of the abnormal aggregation of alpha-synuclein, associated with pervasive cellular death in dopaminergic regions of the brain. However, contrary to other synucleinopathies, like PD, the pattern of alteration seems to spread to more cortical regions, such as the insula ( Roquet et al, 2017 ), and to be associated with both phosphorylated tau and beta-amyloid deposits in the affected regions ( Patterson et al, 2019 ).…”
Section: Introductionmentioning
confidence: 90%