“…It has been recognized for over a decade that TDP-43 pathology is often comorbid with ADNC, Lewy body pathology, or both [ 8 , 10 , 46 , 66 , 67 ]. However, these pathologic features also are commonly seen—even when quite severe—in the absence of each other [ 51 , 52 , 88 , 113 , 147 , 153 , 154 ], so they are at least partly independent. Many studies have demonstrated that LATE-NC is associated with additive cognitive impairment for a given amount of other pathologic changes [ 4 , 16 , 17 , 72 , 103 , 111 , 127 ].…”