Neuropathogenic and non-neuropathogenic variants of equine herpesvirus 1 in France

Pronost, Stéphane; Léon, Albertine; Legrand, Loïc; Fortier, Christine; Miszczak, Fabien; Freymuth, F.; Fortier, Guillaume

doi:10.1016/j.vetmic.2010.03.031

Cited by 48 publications

(57 citation statements)

References 19 publications

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“…This prevalence was lower than those observed in the U.S.A. (10.8-19.4%), Argentina (7.4%), France (24%), and Germany (10.6%) [11,23,24,26,28]. The samples that we analyzed were collected mainly from fetuses aborted in sporadic abortions or from outbreaks of non-neurological EHV-1.…”

Section: )mentioning

confidence: 62%

Prevalence of Equine Herpesvirus Type 1 Strains of Neuropathogenic Genotype in a Major Breeding Area of Japan

Tsujimura

Oyama

Katayama

et al. 2011

The Journal of Veterinary Medical Science

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ABSTRACT. A single non-synonymous nucleotide substitution of guanine (G) for adenine (A) at position 2254 in the viral DNA polymerase gene (encoded by open reading frame [ORF] 30) of equine herpesvirus type 1 (EHV-1) has been significantly associated with neuropathogenic potential in strains of this virus. To estimate the prevalence of EHV-1 strains with the neuropathogenic genotype (ORF30 G 2254 ) in the Hidaka district-a major horse breeding area in Japan-we analyzed the ORF30 genomic region in cases of EHV-1 infection in this area during the years 2001-2010. Of the 113 cases analyzed, 3 (2.7%) were induced by ORF30 G 2254 strains. This prevalence is lower than those observed in the U.S

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Section: )mentioning

confidence: 62%

Prevalence of Equine Herpesvirus Type 1 Strains of Neuropathogenic Genotype in a Major Breeding Area of Japan

Tsujimura

Oyama

Katayama

et al. 2011

The Journal of Veterinary Medical Science

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“…The apparent association of G2254/D752 strains, rather than A2254/N752 strains, with neuropathogenic disease has been a particular focus of studies of EHV‐1 pathogenesis in recent years (Fritsche & Borchers, 2011; Pronost et al., 2010; Stasiak, Rola, Ploszay, Socha, & Zmudzinski, 2015; Tsujimura et al., 2011). Sometimes overlooked is the finding in the field that the association of abortion with the EHV‐1 A2254/N752 strain variant was more statistically significant (Nugent et al., 2006).…”

Section: Discussionmentioning

confidence: 99%

Genetic diversity of equine herpesvirus 1 isolated from neurological, abortigenic and respiratory disease outbreaks

Bryant

Wilkie

Russell

et al. 2018

Transbound Emerg Dis

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SummaryEquine herpesvirus 1 (EHV‐1) causes respiratory disease, abortion, neonatal death and neurological disease in equines and is endemic in most countries. The viral factors that influence EHV‐1 disease severity are poorly understood, and this has hampered vaccine development. However, the N752D substitution in the viral DNA polymerase catalytic subunit has been shown statistically to be associated with neurological disease. This has given rise to the term “neuropathic strain,” even though strains lacking the polymorphism have been recovered from cases of neurological disease. To broaden understanding of EHV‐1 diversity in the field, 78 EHV‐1 strains isolated over a period of 35 years were sequenced. The great majority of isolates originated from the United Kingdom and included in the collection were low passage isolates from respiratory, abortigenic and neurological outbreaks. Phylogenetic analysis of regions spanning 80% of the genome showed that up to 13 viral clades have been circulating in the United Kingdom and that most of these are continuing to circulate. Abortion isolates grouped into nine clades, and neurological isolates grouped into five. Most neurological isolates had the N752D substitution, whereas most abortion isolates did not, although three of the neurological isolates from linked outbreaks had a different polymorphism. Finally, bioinformatic analysis suggested that recombination has occurred between EHV‐1 clades, between EHV‐1 and equine herpesvirus 4, and between EHV‐1 and equine herpesvirus 8.

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“…There are only few reports available in literature on EHM in France (Pronost et al, 2010b;Pronost et al, 2012) and none describe risk factors. Moreover, epidemiological studies are often restricted to a single outbreak, thereby limiting their potential at identifying risk factors unrelated to a specific outbreak.…”

Section: Introductionmentioning

confidence: 99%

A retrospective study on equine herpesvirus type-1 associated myeloencephalopathy in France (2008–2011)

Galen

Leblond

Tritz³

et al. 2015

Veterinary Microbiology

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Please cite this article as: Galen, Gaby van, Leblond, Agnes, Tritz, Pierre, Martinelle, Ludovic, Pronost, Stéphane, Saegerman, Claude, A retrospective study on equine herpesvirus type-1 associated myeloencephalopathy in France (2008France ( -2011.Veterinary Microbiology http://dx.doi.org/10. 1016/j.vetmic.2015.07.003 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. and geographic location, risk factors were found to be similar to previous studies, therefore strengthening their significance to the spread of EHM.

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Neuropathogenic and non-neuropathogenic variants of equine herpesvirus 1 in France

Cited by 48 publications

References 19 publications

Prevalence of Equine Herpesvirus Type 1 Strains of Neuropathogenic Genotype in a Major Breeding Area of Japan

Prevalence of Equine Herpesvirus Type 1 Strains of Neuropathogenic Genotype in a Major Breeding Area of Japan

Genetic diversity of equine herpesvirus 1 isolated from neurological, abortigenic and respiratory disease outbreaks

A retrospective study on equine herpesvirus type-1 associated myeloencephalopathy in France (2008–2011)

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