Neuropathie optique rétrobulbaire et lymphome malin non hodgkinien

Finke, E; Hage, Rabih; Donnio, A; Bomahou, C.; Guyomarch, J.; Sutter, Charles W.; Ventura, Elvira; Merle, H.

doi:10.1016/j.jfo.2011.03.017

Cited by 7 publications

(4 citation statements)

References 13 publications

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“…However, an intraocular lymphoma secondary to systemic lymphoma is not common and is usually limited to the uveal tract [5,9]. There are several reports of the optic nerve involvement in cases of systemic NHL [10][11][12]. Several cases of infiltrative optic neuropathy have also been reported which may be the first manifestation of a recurrence of the NHL [11,13].…”

Section: Discussionmentioning

confidence: 99%

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Bilateral Central Retinal Vein Occlusion in a Patient with Mantle Cell Lymphoma

Oshitari¹

2017

OCR

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Background: A Mantle Cell Lymphoma (MCL) is an aggressive B cell lymphoma and accounts for approximately 6% of all non-Hodgkin's lymphomas. A MCL has a poor prognosis with a median survival of about two to five years. We present our findings in a case of bilateral Central Retinal Vein Occlusion (CRVO) that developed in a patient with MCL. Case Presentation:A 70-year-old woman was diagnosed with primary tonsil MCL in March 2009 and progressed to complete remission after chemotherapy. In March 2014, the decimal visual acuity in her right eye decreased to 0.01 due to a CRVO. Although malignant cells were not detected in the cerebrospinal fluid, methotrexate and dexamethasone were injected intraspinally. Two weeks later, the vision in her left eye decreased to 0.03, and she was found to have a CRVO in her left eye. Hematological and systemic evaluations eliminated hypercoagulability and autoimmune disorders. Although MRI and CT showed no central nervous infiltrations, the clinical features suggested that the CRVO was related to the recurrence of the lymphoma. She was treated with an intravitreal injection of anti-VEGF (aflibercept) and panrential photocoagulation. The macula edema improved and neovascular glaucoma was prevented. Her vision did not recover because of the retinal and optic nerve ischemia. Conclusion:Bilateral CRVO can be associated with MCL although it is extremely rare. Nevertheless, clinicians should be aware of this association because a CRVO is a clinical sign of relapsing malignant ocular lymphoma.

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Section: Discussionmentioning

confidence: 99%

“…Additionally, no lymphocytes were found the CSF. In earlier cases, most patients who had the optic nerve involvement with systemic diseases had positive neuroimaging with enhancement of the optic nerve or positivity for malignant cells in the CSF [10][11][12]16].…”

Section: Citation: Furuya N Oshitari T Sato E Baba T Yamamoto S (mentioning

confidence: 99%

Bilateral Central Retinal Vein Occlusion in a Patient with Mantle Cell Lymphoma

Oshitari¹

2017

OCR

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“…One patient initially had improvement in visual acuity, but then subsequently lost vision in both eyes prior to death 6 weeks later. 16 Three patients had no change in visual acuity with treatment and the patient who presented with a combined central retinal artery and vein occlusion developed neovascular glaucoma. Two patients in this category expired 6 weeks and 7 months after onset of visual symptoms, respectively.…”

Section: Clinical Categories Of Lymphomatous Optic Nerve Involvementmentioning

confidence: 96%

“…This category includes cases 16,28,29,50 where, after visual symptoms occurred, CSF analysis was positive for malignant cells. However these CSF positive patients did not have any further evidence of CNS disease as manifested by other cranial neuropathies or lesions on neuroimaging.…”

Section: Clinical Categories Of Lymphomatous Optic Nerve Involvementmentioning

confidence: 99%

Optic nerve lymphoma: Report of two cases and review of the literature

Kim

Mendoza

Rashid

et al. 2015

Survey of Ophthalmology

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Lymphoma may involve the optic nerve as isolated optic nerve lymphoma or in association with CNS or systemic lymphoma. We present two biopsy-proven non-Hodgkin lymphomas of the optic nerve and compare our findings with previously reported cases. We discuss the mechanism of metastasis, classification of optic nerve involvement, clinical features, radiologic findings, optic nerve biopsy indications and techniques, histologic features, and treatments. We propose a classification system of optic nerve lymphoma: isolated optic nerve involvement, optic nerve involvement with CNS disease, optic nerve involvement with systemic disease, and optic nerve involvement with primary intraocular lymphoma. Although it is an uncommon cause of infiltrative optic neuropathy, optic nerve metastasis should be considered in patients with a history of lymphoma. The recommended approach to a patient with presumed optic nerve lymphoma includes neuroimaging, and cerebrospinal fluid evaluation as part of the initial work-up, then judicious use of optic nerve biopsy, depending on the clinical situation.

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