Neuropathic pruritus (itch) in neuromyelitis optica

Elsone, Liene; Townsend, Tristan; Mutch, Kerry; Das, Kumar; Boggild, Mike; Nurmikko, Turo; Jacob, Anu

doi:10.1177/1352458512457720

Cited by 76 publications

(60 citation statements)

References 20 publications

(33 reference statements)

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“…Another study described a cohort of patients with NMO who had pruritus associated with spinal cord lesions at different levels or of different size. 25 Involvement of 'itch specific' neurons and pathways in the spinal cord was considered to be the mechanism. It is possible that similar mechanisms operate in the brainstem affecting the 'itch specific' neurons of the trigeminal sensory pathway or ascending pathways from the spinal cord.…”

Section: Discussionmentioning

confidence: 99%

Brainstem manifestations in neuromyelitis optica: a multicenter study of 258 patients

Mealy²,

et al. 2013

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Section: Discussionmentioning

confidence: 99%

Brainstem manifestations in neuromyelitis optica: a multicenter study of 258 patients

Mealy²,

et al. 2013

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“…In a study looking at the point prevalence of pruritus in people with recent shingles, 17 % of adults from Finland reported itch, 36 % from Liverpool, and 58 % from Seattle (Oaklander et al 2003). Neuromyelitis optica has also been associated with pruritus; in a small study of 44 patients, 27.3 % reported pruritus (Elsone et al 2013).…”

Section: Other Diseasesmentioning

confidence: 99%

Pruritus Epidemiology and Quality of Life

Leader¹,

Carr²,

Chen³

2015

Handbook of Experimental Pharmacology

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The burden of chronic pruritus is increasingly recognized as significant worldwide. As wet-laboratory researchers investigate the pathophysiology of chronic pruritus, epidemiologists and health services researchers are quantifying the impact of pruritus by incidence, prevalence, and quality of life measures. Outcomes researchers are also investigating factors that may predict chronic pruritus incidence and severity. Such efforts will direct resources for research, public health intervention, and clinical care.

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“…Painful tonic spasms during myelitis recovery and severe pain are found in NMOSD more commonly than in MS 25,26 . Neuropathic pruritus (itch) has also been recently reported in NMOSD patients during myelitis attacks 27 . Secondary progression without evidence of attacks suggestive of chronic progressive myelopathy is sometimes observed in MS, but it is not a common evolution seen on NMOSD 1,28 .…”

Section: The Differential Diagnosis Of Nmosdmentioning

confidence: 86%

Seronegative Neuromyelitis Optica Spectrum - The challenges on disease definition and pathogenesis

Sato

Callegaro

Lana-Peixoto

et al. 2014

Arq. Neuro-Psiquiatr.

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Neuromyelitis optica spectrum disorders (NMOSD) are characterized by severe optic neuritis and/or longitudinally extensive transverse myelitis, and some brain lesions are also unique to NMOSD. Serum autoantibodies against aquaporin-4 (AQP4) are detected in most cases of NMOSD. However, some patients with NMOSD remain seronegative despite repetitive testing during attacks with highly sensitive cellbased assays. The differential diagnosis of NMOSD is not restricted to multiple sclerosis and it includes many diseases that can produce longitudinally extensive myelitis and/or optic neuritis. We review the clinical features, imaging, and laboratory findings that can be helpful on the diagnostic work-up, discuss the differences between AQP4 antibody positive and negative patients with NMOSD, including features of NMOSD with antibodies against myelin oligodendrocyte glycoprotein.Keywords: neuromyelitis optica, aquaporin-4, myelin oligodendrocyte glycoprotein, antibody, myelitis, optic neuritis, differential diagnosis. RESUMOO espectro da neuromielite óptica (NMOSD) é caracterizado por ataques graves de neurite óptica e mielite. Anticorpos séricos contra a aquaporina-4 (AQP4) são usualmente presentes nestes pacientes. Entretanto, alguns pacientes com NMOSD são seronegativos mesmo com testes repetidos em amostras obtidas durante ataques usando métodos altamente sensíveis baseados em células. O diagnóstico diferencial não é restrito à esclerose múltipla e inclui muitas doenças que podem produzir mielite longitudinalmente extensa e/ou neurite óptica. São abordadas as características clínicas, de imagem e de laboratório que podem ser úteis no diagnóstico, as diferenças entre os pacientes positivos para o anticorpo anti-AQP4 e os negativos, incluindo as características dos pacientes com NMOSD que possuem anticorpos contra a glicoproteína associada ao oligodendrócito.Palavras-chave: neuromielite óptica, aquaporina-4, glicoproteína associada ao olidendrócito, mielite, neurite óptica, diagnóstico diferencial.

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Neuropathic pruritus (itch) in neuromyelitis optica

Abstract: Neuropathic pruritus seems to be a common, but under-recognised symptom of myelitis associated with NMO.

Cited by 76 publications

References 20 publications

Brainstem manifestations in neuromyelitis optica: a multicenter study of 258 patients

Brainstem manifestations in neuromyelitis optica: a multicenter study of 258 patients

Pruritus Epidemiology and Quality of Life

Seronegative Neuromyelitis Optica Spectrum - The challenges on disease definition and pathogenesis

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