Neuropathic pain in patients with osteoarthritis of hip joint

Shigemura, Tomonori; Ohtori, Seiji; Kishida, Shunji; Nakamura, Junichi; Takeshita, Mitsuru; Takazawa, Makoto; Harada, Yoshitada; Takahashi, Kazuhisa

doi:10.1007/s12570-011-0070-x

Cited by 25 publications

(29 citation statements)

References 37 publications

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“…Shirai et al [28] stated that hip pain occurs following the invasion of the labrum with blood vessels and nerve fibers from inflamed synovial tissue following labral degeneration in the hip joint affected by OA. Shigemura et al [2] reported that 6% of patients with OA of the hip showed neuropathic pain. These find-ings may provide the development of novel analgesic therapies for hip joint pain including the treatments targeting NGF.…”

Section: Discussionmentioning

confidence: 99%

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A novel rat model of hip pain by intra-articular injection of nerve growth factor-characteristics of sensory innervation and inflammatory arthritis

Omae

Nakamura

Ohtori

et al. 2015

Modern Rheumatology

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Section: Discussionmentioning

confidence: 99%

“…However, referred pain may occur in osteoarthritis (OA) [1][2], osteonecrosis [3][4], acetabular labral lesion [5], and other hip disorders. Pain has been reported to affect the thigh or lower leg as well as the hip itself.…”

Section: Introductionmentioning

confidence: 99%

A novel rat model of hip pain by intra-articular injection of nerve growth factor-characteristics of sensory innervation and inflammatory arthritis

Omae

Nakamura

Ohtori

et al. 2015

Modern Rheumatology

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“…No previous studies are available on the correlation between mPDQ and the VAS pain or subscales of KOOS/HOOS and RAND-36. However, some results are available for the correlation between the PDQ (unmodified), VAS pain and subscales of the RAND-36, reporting correlations between VAS pain and PDQ of 0.39, and of 0.53 in hip and knee OA patients [20,46]. A correlation of 0.30 between PDQ and the RAND-36 pain subscale was previously described [42].…”

Section: Construct Validitymentioning

confidence: 93%

“…In hip OA, up to 19% of the patients and in knee OA 19-37% of the patients experience possible or likely neuropathic pain [3,[19][20][21][22][23]. Besides clinical assessment by specialised pain physicians and elaborate protocols for physical examination for neuropathic symptoms [quantitative sensory testing, (QST)], several questionnaires are available to distinguish neuropathic pain symptoms from nociceptive pain symptoms.…”

Section: Introductionmentioning

confidence: 99%

Validity of the Dutch modified painDETECT questionnaire for patients with hip or knee osteoarthritis

Rienstra

Blikman

Dijkstra

et al. 2017

Disability and Rehabilitation

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This study is the first to assess structural and construct validity of the modified PDQ knee/hip by using factor analysis and hypothesis-testing. This questionnaire seems to reflect neuropathic-like pain symptoms experienced by hip/knee OA-patients with adequate validity. The item on pain pattern might not reflect the construct. More than 75% of the predefined hypotheses regarding the modified PDQ and the other questionnaires were met. Only 50% of the hypotheses on PPTs measurements were met, probably due to heterogeneity and limited size of this subsample. Implications for rehabilitation Pain in osteoarthritis (OA) is partly caused by modification of pain transmission in the peripheral and central nervous system, leading to sensitisation. This process seems particularly significant in a subgroup of OA patients. Sensitisation in OA is associated with more disability in daily life, lower quality of life and more widespread pain, as well as poorer outcome of total joint surgery. Screening for sensitisation can help to identify the subgroup of patients who could benefit from multidisciplinary treatment options focussing on desensitisation, cognitive- and behavioural therapy and reducing chronification of widespread pain. Therefore, being particularly important in the field of rehabilitation. The Dutch modified PainDETECT-questionnaire is very useful for rehabilitation professionals as it is one of the first questionnaires specifically validated to assess neuropathic-like symptoms (indicating sensitisation) in patients with knee or hip osteoarthritis.

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“…Osteoarthritis (OA) is a common chronic degenerative disease characterized by loss of articular cartilage . Major clinical signs of hip OA are groin pain with weight bearing, restricted range of motion, and gait disturbance, which deteriorates the quality of life of affected individuals. Referred pain may occur in OA.…”

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confidence: 99%

Pain-related behavior and the characteristics of dorsal-root ganglia in a rat model of hip osteoarthritis induced by mono-iodoacetate

et al. 2017

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The principal aim of this study was to clarify the time course of pain-related behavior and pain-related sensory innervation in a rat model of hip osteoarthritis (OA) induced by intra-articular injection of mono-iodoacetate (MIA). Using 6-week-old male Sprague Dawley rats, 25 μl of sterile saline of 1% Fluoro-Gold solution (FG) (control group; n = 30) and 25 μl of sterile saline of 1% FG with 2 mg of MIA (MIA group; n = 30) was injected into the right hip joints. Gait function was evaluated using a CatWalk system after 7, 14, 28, 42, and 56 days (n = 5, respectively). Neurons in the dorsal root ganglion (DRG) between L1 and L5 were immunostained for calcitonin gene-related peptide (CGRP) and activating transcription factor-3 (ATF3). Gait analysis revealed the mean six parameters of hind paws at all time points were significantly lower in the MIA group (p = 0.05). The number of CGRP-immunoreactive (-IR) DRG neurons was significantly increased on days 7, 14, 28, and 42 peaking at 14 days in the MIA group. By contrast, expression of ATF3-IR in FG-labeled DRG neurons was significantly increased on days 42 and 57. The FG-labeled DRG neurons were distributed between L1 and L5, mainly at the L4 level. Pain-related behavior indicated by gait disturbance was observed in a MIA model of hip OA in rat. Early elevation of CGRP expression and late expression of ATF-3 were demonstrated in DRG neurons, possibly reflecting inflammatory pain and neuropathic pain in hip OA. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:1424-1430, 2017.

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Neuropathic pain in patients with osteoarthritis of hip joint

Abstract: Objectives The aim of the present study was to evaluate the relationship between neuropathic pain and pain deriving from osteoarthritis of the hip joint, using painDETECT, a self-report questionnaire.

Cited by 25 publications

References 37 publications

A novel rat model of hip pain by intra-articular injection of nerve growth factor-characteristics of sensory innervation and inflammatory arthritis

A novel rat model of hip pain by intra-articular injection of nerve growth factor-characteristics of sensory innervation and inflammatory arthritis

Validity of the Dutch modified painDETECT questionnaire for patients with hip or knee osteoarthritis

Pain-related behavior and the characteristics of dorsal-root ganglia in a rat model of hip osteoarthritis induced by mono-iodoacetate

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