Neuropathic pain in a chronic CNS injury model is mediated by CST-targeted spinal interneurons
Xiaofei Guan,
Yanjie Zhu,
Jian Zhong
et al.
Abstract:Chronic neuropathic pain is a persistent and debilitating outcome of traumatic central nervous system injury, affecting up to 80% of individuals with chronic injury. Post-injury pain is refractory to clinical treatments due to the limited understanding of the brain-spinal cord circuits that underlie pain signal processing. The corticospinal tract (CST) plays critical roles in sensory modulation during skilled movements and tactile sensation; however, a direct role for the CST in injury-associated neuropathic p… Show more
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