Neuropathic Pain Components in Patients with Lumbar Spinal Stenosis

Park, Si Young; Hong, Jae‐Young

doi:10.1016/j.spinee.2013.07.308

Cited by 7 publications

(13 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…NP affects approximately 7-10% of the general population [4,27], [20][21][22][23][24][25][26].4% of individuals with diabetes [5,11], and 10-20% of individuals following herpes zoster in the UK [24,37,76]. Up to 37% of individuals with low back pain [22,54] and 40% of people after surgery [36] suffer from NP. Studies have found that NP affects approximately 8.1 and 17.9% of the Canadian population [67,70].…”

mentioning

confidence: 99%

Systematic review and meta-analysis of genetic risk factors for neuropathic pain

Veluchamy

Hébert

Wang

et al. 2018

Pain

View full text Add to dashboard Cite

Neuropathic pain (NP) is an increasingly common chronic pain state and a major health burden, affecting approximately 7% to 10% of the general population. Emerging evidence suggests that genetic factors could partially explain individual susceptibility to NP and the estimated heritability in twins is 37%. The aim of this study was to systematically review and summarize the studies in humans that have investigated the influence of genetic factors associated with NP. We conducted a comprehensive literature search and performed meta-analyses of all the potential genetic variants associated with NP. We reviewed 29 full-text articles and identified 28 genes that were significantly associated with NP, mainly involved in neurotransmission, immune response, and metabolism. Genetic variants in HLA genes, COMT, OPRM1, TNFA, IL6, and GCH1, were found to have an association with NP in more than one study. In the meta-analysis, polymorphisms in HLA-DRB1*13 (odds ratio [OR], 2.96; confidence interval [CI], 1.93-4.56), HLA-DRB1*04 (OR, 1.40; CI, 1.02-1.93), HLA-DQB1*03 (OR, 2.86; CI, 1.57-5.21), HLA-A*33 (OR, 2.32; CI, 1.42-3.80), and HLA-B*44 (OR, 3.17; CI, 2.22-4.55) were associated with significantly increased risk of developing NP, whereas HLA-A*02 (OR, 0.64; CI, 0.47-0.87) conferred reduced risk and neither rs1799971 in OPRM1 (OR, 0.55; CI, 0.27-1.11) nor rs4680 in COMT (OR, 0.95; CI, 0.81-1.13) were significantly associated with NP. These findings demonstrate an important and specific contribution of genetic factors to the risk of developing NP. However, large-scale replication studies are required to validate these candidate genes. Our review also highlights the need for genome-wide association studies with consistent case definition to elucidate the genetic architecture underpinning NP.

show abstract

mentioning

confidence: 99%

Systematic review and meta-analysis of genetic risk factors for neuropathic pain

Veluchamy

Hébert

Wang

et al. 2018

Pain

View full text Add to dashboard Cite

show abstract

“…In patients with LSS, pain mostly spreads to the buttock or thighs and to both lower legs, with patients also complaining of numbness and tingling (19). For patients with chronic low back pain and LSS, other researchers have also reported that buttock and leg pain were significantly associated with NeP (10,22). Our results are consistent with these results, showing that most subjects complained of leg symptoms (e.g., tingling in 67.1% and numbness in 51.9%), including claudication (41.8%), and that very few complained of itching (Table 3).…”

Section: Resultsmentioning

confidence: 99%

Neuropathic Pain and Disability in Patients with Lumbar Spinal Stenosis

Ağırman¹,

Akgün²

2018

tjgeri

View full text Add to dashboard Cite

In this study, we aimed to determine the characteristics of neuropathic pain and clarify the relationships between the clinical signs, symptom characteristics and disability in patients with lumbar spinal stenosis. Materials and Method: Seventy-nine patients diagnosed with clinical and radiological lumbar spinal stenosis were included in the study. Pain severity was assessed using a selfadministered visual analog scale (0-10 cm). Subjective disability was measured using the Oswestry Disability Index and Istanbul Low Back Pain Disability Index. To identify neuropathic pain, the physician-administered Douleur Neuropathique 4 questionnaire was utilized. Results: A total of 79 patients (35 males, 44 females) with a mean age of 56.88±12.13 (range, 35-89) years were included in the study. The average symptom duration was 24.5 months. The Douleur Neuropathique 4 score was ≥4 in 41 patients (51.8%), indicating that they had neuropathic pain. A significant correlation was observed between the Douleur Neuropathique 4 score and age (R=0.350, p=0.002), body mass index (R=0.239, p=0.034), and visual analog scale (R=0.453, p< 0.001). Conclusion: Approximately half of all patients with lumbar spinal stenosis in our cohort had neuropathic pain. Higher age, body mass index and increased pain scores demonstrate important relationships with neuropathic pain.

show abstract

“…86,87 Za bolesnike sa stenozom spinalnog kanala slabinske regije često je potrebna kombinirana terapija kojom bi se kontrolirale nociceptivna i neuropatska komponenta boli, s tim da je potonja prema nekim autorima prisutna u oko trećine ovih bolesnika. 88 Nema dokaza koji bi poduprli upotrebu NSAR-a za liječenje neuropatske sastavnice boli, a farmakoterapija često uključuje antidepresive i antikonvulzive. 89 Premda metaanalize pokazuju kontradiktorne podatke o učincima antidepresiva u kroničnoj križobolji, nekoliko je studija upozorilo na učinkovitost antidepresiva duloksetina u bolesnika s tim stanjem, radi bolje kontrole boli i poboljšanja funkcionalne sposobnosti.…”

Section: Konzervativno Liječenje Stenoze Spinalnog Kanala Lumbalne Reunclassified

Lumbar Spinal Stenosis – From Epidemiology to Rehabilitation

2018

View full text Add to dashboard Cite

Deskriptori: Spinalna stenoza-etiologija, dijagnoza, kirurgija, rehabilitacija; Slabinska kralješnica-anatomija, kirurgija, patologija; Fizioterapijski postupci; Kirurška dekompresija-metode; Spinalna fuzija-metode; Minimalno invazivni kirurški zahvati-metode Sažetak. Prevalencija stenoze spinalnog kanala slabinske regije u stalnom je porastu zbog starenja pučanstva. Naime, unatoč etiološkoj raznovrsnosti, ona najčešće nastaje kao posljedica degenerativnih promjena na kralježnici. Nema općeprihvaćene klasifi kacije stenoze spinalnog kanala slabinske regije. Za postavljanje dijagnoze potrebno je povezati nalaze iz anamneze, kliničkog statusa i slikovnih metoda zajedno s elektrofi ziološkim nalazima. Liječenje bolesnika sa stenozom spinalnog kanala slabinske regije može biti konzervativno (farmakološko i nefarmakološko) i kirurško, s tim da se u potonjem u posljednje vrijeme preferiraju minimalno invazivne tehnike. U ovom radu dajemo sveobuhvatni suvremeni pogled na stenozu spinalnog kanala slabinske regije.

show abstract

Neuropathic Pain Components in Patients with Lumbar Spinal Stenosis

Cited by 7 publications

References 29 publications

Systematic review and meta-analysis of genetic risk factors for neuropathic pain

Systematic review and meta-analysis of genetic risk factors for neuropathic pain

Neuropathic Pain and Disability in Patients with Lumbar Spinal Stenosis

Lumbar Spinal Stenosis – From Epidemiology to Rehabilitation

Contact Info

Product

Resources

About