Neuropathic Pain and Rehabilitation: A Systematic Review of International Guidelines

Bernetti, Andrea; Agostini, Francesco; Sire, Alessandro de; Mangone, Massimiliano; Tognolo, Lucrezia; Cesare, A. Di; Ruiu, Pierangela; Paolucci, Teresa; Invernizzi, Marco; Paoloni, Marco

doi:10.3390/diagnostics11010074

Cited by 55 publications

(44 citation statements)

References 26 publications

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“…Non-specific neck pain (NNP) is a symptom related to postural or mechanical cause [ 1 , 2 ]. In most patients, neck pain can be a common cause of disability: it is associated with daily activity limitations, reduction of work productivity and decrease in quality of life [ 3 , 4 ]. Neck pain has a socioeconomic impact [ 5 , 6 , 7 , 8 , 9 ] because of physical and psychological symptoms that are related [ 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Muscle Energy Technique in the Rehabilitative Treatment for Acute and Chronic Non-Specific Neck Pain: A Systematic Review

et al. 2021

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Background: Non-specific neck pain (NNP) affects 30–50% of the general population, and it often leads to severe disability. Several manual therapy techniques are available to reduce pain and disability and to improve cervical range of motion and functional activities. Muscle Energy Technique (MET) showed more evidence for treating such a disorder. The aim of this current scientific literature analysis was to compare the clinical effects of MET with the other manual or rehabilitative treatments for non-specific acute and chronic neck pain. Methods: The literature search was conducted using the following databases: PubMed, Medline, PEDro, Cochrane Database, and Google Scholar from 2010 to January 2020. Clinical trials about MET were included. The quality of the trials was assessed according to the PEDro scale. Results: Twenty-one papers according to inclusion and exclusion criteria were selected: 15 studies about non-specific acute neck pain and 6 studies about non-specific chronic neck pain. Conclusions: This analysis suggests that the MET approach has a good clinical effect on reducing neck pain in patients with acute neck pain and improves cervical range of motion in patients with chronic neck pain, and is better if combined with a traditional rehabilitative approach. This review’s findings should be considered with caution for physiotherapy practice because of the studies’ methodologic limitations. On the basis of the current available and limited evidence, clinicians could combine MET with traditional physiotherapy and other manual techniques when treating people with non-specific neck pain.

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Section: Introductionmentioning

confidence: 99%

Muscle Energy Technique in the Rehabilitative Treatment for Acute and Chronic Non-Specific Neck Pain: A Systematic Review

et al. 2021

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“…Sciatic nerve injury (SNI) is more closely related to allodynia than to dysesthesia ( Mukai et al, 2019 ). Patients with neuropathic pain after SNI have suffered from poor quality of life due to anxiety, depression and severe pain ( Bernetti et al, 2021 ). Therefore, many researchers have tried to find out mechanisms of neuropathic pain for several decades ( Finnerup et al, 2021 ), but the mechanism is not yet clear.…”

Section: Introductionmentioning

confidence: 99%

Effect of treadmill exercise on pain-related Wnt/β-catenin signaling pathway in dorsal root ganglion neurons at the early phase regeneration of the injured sciatic nerve

Cho¹,

Kim²,

Seo³

2021

J Exerc Rehabil

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The purpose of this study was to determine whether treadmill walking exercise can improve mechanical allodynia through regulation of Wnt/ β-catenin signaling in dorsal root ganglion (DRG) neurons at the early stage of regeneration after sciatic nerve injury (SNI). The experimental rats were divided into seven groups: the normal control, sedentary groups for 3-, 7-, and 14-day post crush (dpc), and exercise group for 3, 7, and 14 dpc. The rats in exercise groups performed treadmill walking exercise at a speed of 8 m/min for 20 min once a day according to experiment duration. For evaluating neuropathic pain-like behavior after SNI, the mechanical allodynia was examined by von Frey apparatus. And the expression levels of pain-related protein were identified in the cytoplasm or nucleus of DRG neurons using Western blot techniques. Mechanical allodynia was significantly ameliorated in the exercise group at 7 and 14 dpc. Treadmill exercise further decreased Wnt3a expression at 3, 7, and 14 dpc compared to in the sedentary group. Also, phosphorylated-low-density lipoprotein receptor 6 was decreased in exercise groups at 3 and 14 dpc. Beta-catenin was significantly decreased in exercise groups at 3 and 14 dpc compared to sedentary groups as well as treadmill exercise decreased translocation of β-catenin towards the nucleus of DRG neurons at 14 dpc. Our findings indicate that treadmill walking exercise may be an important regulator of neuropathic pain after peripheral nerve injury through delayed Wnt/ β-catenin signaling pathway in DRG neurons.

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“…The course is generally benign and acute episodes tend to resolve spontaneously within a few weeks. Relapses are frequent but in 10% of cases the symptoms tend to become chronic [5]. This pathology has a strong impact in the workplace as 11-14% of workers encounter a limitation of work activities [6,7].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of TENS in Cervical Pain Syndromes: An Umbrella Review of Systematic Reviews

et al. 2021

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Neck pain is defined as perceived pain, originating in an area bounded above by the nuchal line, below by an imaginary line passing through the spinous process of T1 and laterally by the sagittal plane tangent to the lateral edges of the neck. Our purpose is to investigate the effectiveness of transcutaneous electrical nerve stimulation (TENS) in patients suffering from both acute and chronic cervical pain syndromes. The literature research was conducted by consulting the following databases: PubMed, PEDro, Cochrane, and Google Scholar. To formulate the scientific question correctly, the PICO model was used. This umbrella review includes all systematic reviews with or without meta-analysis, in English, which analyze the use of TENS in subjects suffering from acute or chronic cervical pain. To evaluate the methodological quality of the studies, the AMSTAR model. A total of eleven systematic reviews with or without meta-analyses were included. The results of the study show how TENS seems to have an effect in reducing the intensity of acute and chronic cervical pain, especially in the short term. However, it was not possible to provide precise recommendations in this regard. Based on our result, it is desirable to carry out further studies that support the effectiveness of using TENS in patients suffering from acute and chronic neck pain.

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Neuropathic Pain and Rehabilitation: A Systematic Review of International Guidelines

Cited by 55 publications

References 26 publications

Muscle Energy Technique in the Rehabilitative Treatment for Acute and Chronic Non-Specific Neck Pain: A Systematic Review

Muscle Energy Technique in the Rehabilitative Treatment for Acute and Chronic Non-Specific Neck Pain: A Systematic Review

Effect of treadmill exercise on pain-related Wnt/β-catenin signaling pathway in dorsal root ganglion neurons at the early phase regeneration of the injured sciatic nerve

Efficacy of TENS in Cervical Pain Syndromes: An Umbrella Review of Systematic Reviews

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