Neuropathic pain after spinal cord injury and physical exercise in animal models: A systematic review and meta-analysis

Palandi, Juliete; Bobinski, Franciane; Oliveira, Gabriela Martins de; Ilha, Jocemar

doi:10.1016/j.neubiorev.2019.12.016

Cited by 24 publications

(14 citation statements)

References 62 publications

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“…In general, aerobic exercise protocols reduce exaggerated responses (i.e., hypersensitivities) to these tests. In fact, recent metaanalyses concluded exercise training reduced nociceptive responses to mechanical and thermal tests compared to no exercise controls in animal models of peripheral nerve injury (i.e., SNI and DPN) [56] and SCI [57].…”

Section: Preclinical Evidencementioning

confidence: 99%

Exercise and Neuropathic Pain: A General Overview of Preclinical and Clinical Research

Leitzelar

Koltyn

2021

Sports Med - Open

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Neuropathic pain is a disease of the somatosensory system that is characterized by tingling, burning, and/or shooting pain. Medication is often the primary treatment, but it can be costly, thus there is an interest in understanding alternative low-cost treatments such as exercise. The following review includes an overview of the preclinical and clinical literature examining the influence of exercise on neuropathic pain. Preclinical studies support the hypothesis that exercise reduces hyperalgesia and allodynia in animal models of neuropathic pain. In human research, observational studies suggest that those who are more physically active have lower risk of developing neuropathic pain compared to those who are less active. Exercise studies suggest aerobic exercise training (e.g., 16 weeks); a combination of aerobic and resistance exercise training (e.g., 10–12 weeks); or high-intensity interval training (e.g., 15 weeks) reduces aspects of neuropathic pain such as worst pain over the past month, pain over the past 24 h, pain scores, or pain interference. However, not all measures of pain improve following exercise training (e.g., current pain, heat pain threshold). Potential mechanisms and future directions are also discussed to aid in the goal of understanding the role of exercise in the management of neuropathic pain. Future research using standardized methods to further understanding of the dose of exercise needed to manage neuropathic pain is warranted.

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Section: Preclinical Evidencementioning

confidence: 99%

Exercise and Neuropathic Pain: A General Overview of Preclinical and Clinical Research

Leitzelar

Koltyn

2021

Sports Med - Open

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“…Experimental and clinical evidence suggest that physical exercise influences pathological pain, both neuropathic and nociplastic. Studies evaluating the effect of exercise after spinal cord injury indicate that the intervention significantly improves mechanical allodynia and thermal hyperalgesia in injured subjects [671]. In rats subjected to spinal cord contusion, exercise training in treadmill causes an upregulation of BDNF expression, and this is associated with greater thermal hyperalgesia and mechanical allodynia [672].…”

Section: Pathological Pain: Relationship With Sedentary Behavior and ...mentioning

confidence: 99%

Physiological Changes and Pathological Pain Associated with Sedentary Lifestyle-Induced Body Systems Fat Accumulation and Their Modulation by Physical Exercise

Verdú

Homs

Boadas-Vaello

2021

IJERPH

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A sedentary lifestyle is associated with overweight/obesity, which involves excessive fat body accumulation, triggering structural and functional changes in tissues, organs, and body systems. Research shows that this fat accumulation is responsible for several comorbidities, including cardiovascular, gastrointestinal, and metabolic dysfunctions, as well as pathological pain behaviors. These health concerns are related to the crosstalk between adipose tissue and body systems, leading to pathophysiological changes to the latter. To deal with these health issues, it has been suggested that physical exercise may reverse part of these obesity-related pathologies by modulating the cross talk between the adipose tissue and body systems. In this context, this review was carried out to provide knowledge about (i) the structural and functional changes in tissues, organs, and body systems from accumulation of fat in obesity, emphasizing the crosstalk between fat and body tissues; (ii) the crosstalk between fat and body tissues triggering pain; and (iii) the effects of physical exercise on body tissues and organs in obese and non-obese subjects, and their impact on pathological pain. This information may help one to better understand this crosstalk and the factors involved, and it could be useful in designing more specific training interventions (according to the nature of the comorbidity).

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“…Moreover, placebo effect is a confounding factor on clinical trials studies [29], which is bypassed in animal models, like in the present study. In addition, most of the studies in animals used models of neuropathic pain [15][16][17][18][19][20][21], differently of the present study, where we used a chronic pain model that employs original inflammatory stimulus, mimicking the main types of pain in the clinical setting [22].…”

Section: Discussionmentioning

confidence: 99%

“…In fact, physical exercise has been extensively indicated as non-pharmacological clinical intervention to relieve symptoms in chronic pain conditions such as low back pain, rheumatic diseases, migraine, and fibromyalgia [8][9][10][11][12][13][14]. In animal models of chronic pain, physical exercise has also shown therapeutic effect, although most of the studies were performed in neuropathic pain models such as nerve injury [15][16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Running wheel exercise induces therapeutic and preventive effects on inflammatory stimulus-induced persistent hyperalgesia in mice

et al. 2020

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Chronic pain affects significant portion of the world's population and physical exercise has been extensively indicated as non-pharmacological clinical intervention to relieve symptoms in chronic pain conditions. In general, studies on pain chronification and physical exercise intervention have focused on neuropathic pain, although chronic pain commonly results from an original inflammatory episode. Based on this, the objective of the present study was to investigate the therapeutic and preventive effect of the running wheel exercise on the persistent hyperalgesia induced by repetitive inflammatory stimulus, a rodent model that simulates clinical conditions of chronic pain that persist even with no more inflammatory stimulus present. To evaluate the therapeutic effect of physical exercise, we first induced persistent hyperalgesia through 14 days of PGE2 hind paw injections and, after that, mice have access to the regular voluntary running wheel. To evaluate the preventive effect of physical exercise, we first left the mice with access to the regular voluntary running wheel and, after that, we performed 14 days of PGE2 hind paw injection. Our results showed that voluntary running wheel exercise reduced persistent mechanical and chemical hyperalgesia intensity induced by repetitive inflammatory stimulus. In addition, we showed that this therapeutic effect is long-lasting and is observed even if started belatedly, i.e. two weeks after the development of hyperalgesia. Also, our results showed that voluntary running wheel exercise absolutely prevented persistent mechanical and chemical hyperalgesia induction. We can conclude that physical exercise has therapeutic and preventive effect on inflammatory stimulus-induced persistent hyperalgesia. Our data from animal experiments bypass placebo effects bias of the human studies and reinforce physical exercise clinical recommendations to treat and prevent chronic pain.

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Neuropathic pain after spinal cord injury and physical exercise in animal models: A systematic review and meta-analysis

Cited by 24 publications

References 62 publications

Exercise and Neuropathic Pain: A General Overview of Preclinical and Clinical Research

Exercise and Neuropathic Pain: A General Overview of Preclinical and Clinical Research

Physiological Changes and Pathological Pain Associated with Sedentary Lifestyle-Induced Body Systems Fat Accumulation and Their Modulation by Physical Exercise

Running wheel exercise induces therapeutic and preventive effects on inflammatory stimulus-induced persistent hyperalgesia in mice

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