Neuropathic Orofacial Pain

Christoforou, Janina; Balasubramaniam, Ramesh; Klasser, Gary D.

doi:10.1007/s40496-015-0052-0

Cited by 6 publications

(3 citation statements)

References 96 publications

(96 reference statements)

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“… 4 , 8 , 10 Our data therefore back up previous studies supporting the role of central neuropathic mechanisms in the generation of some orofacial pains. 14 …”

Section: Discussionmentioning

confidence: 99%

Orofacial pain in 1916 patients with early or moderate Parkinson disease

O’Neill

Kobylecki

Carrasco

et al. 2021

PR9

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“… 4 , 8 , 10 Our data therefore back up previous studies supporting the role of central neuropathic mechanisms in the generation of some orofacial pains. 14 …”

Section: Discussionmentioning

confidence: 99%

Orofacial pain in 1916 patients with early or moderate Parkinson disease

O’Neill

Kobylecki

Carrasco

et al. 2021

PR9

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“…The international headache society reported that anatomical boundaries and associated medical specialty demarcations in the orofacial area contributed to the problem ( ICOP, 2020 ). For example, the symptoms of neuropathic pain in the orofacial area often mimic odontogenic toothache, and it can easily be misdiagnosed and misdirected treatment ( Christoforou et al, 2015 ; Christoforou, 2018 ). The orofacial area consists of many kinds of structures innervated by the trigeminal system, head, sinus, masticatory musculature, temporomandibular joint, jaw, teeth, and gingiva, and the complexity induces many kinds of non-odontogenic toothache ( Schames et al, 2016 ).…”

Section: Diagnosis Of Orofacial Neuropathic Painmentioning

confidence: 99%

Orofacial Neuropathic Pain-Basic Research and Their Clinical Relevancies

Shinoda

Imamura

Hayashi

et al. 2021

Front. Mol. Neurosci.

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Trigeminal nerve injury is known to cause severe persistent pain in the orofacial region. This pain is difficult to diagnose and treat. Recently, many animal studies have reported that rewiring of the peripheral and central nervous systems, non-neuronal cell activation, and up- and down-regulation of various molecules in non-neuronal cells are involved in the development of this pain following trigeminal nerve injury. However, there are many unknown mechanisms underlying the persistent orofacial pain associated with trigeminal nerve injury. In this review, we address recent animal data regarding the involvement of various molecules in the communication of neuronal and non-neuronal cells and examine the possible involvement of ascending pathways in processing pathological orofacial pain. We also address the clinical observations of persistent orofacial pain associated with trigeminal nerve injury and clinical approaches to their diagnosis and treatment.

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“…Management approaches can be grouped into three strategies which may be tailored to the individual patient . It has been demonstrated that cognitive behavioural therapy sessions of one‐hour duration weekly over 12 to 15 weeks reduced intensity of OD for up to 6 months .…”

Section: Oral Dysaesthesiamentioning

confidence: 99%

Systemic considerations for orofacial neuropathy

Tiwari

Alsarraf

Yeoh³

et al. 2018

Aust Endodontic J

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Patients with orofacial neuropathic pain typically present with symptoms first hand to their general dental practitioner. It is important dental practitioners recognise the clinical presentations of these conditions for prompt diagnosis and appropriate management. This review will focus on the systemic causes of orofacial neuropathy. Infectious and autoimmune diseases with orofacial neuropathic manifestations such as post-herpetic neuralgia, paroxysmal neuralgias, painful trigeminal sensory neuropathies, peripheral neuritis and oral dysaesthesia will be discussed. Specifically, the prevalence, pathophysiology, clinical presentations and management of these conditions will be reviewed. Post-herpetic neuralgiaPost-herpetic neuralgia (PHN) is a chronic neuropathic pain condition persisting 3 months or greater following reactivation of varicella zoster virus (3). This peripheral system neuropathy results from damage to nervous tissue secondary to a herpes zoster attack. It is the most common neuropathic pain resulting from infection (4).Post-herpetic neuralgia has the potential to cause longterm severe pain, contributing to marked psychosocial dysfunction in the form of impaired sleep, decreased appetite and diminished libido (3,5). The impact of this condition can be drastic enough to transform independent living to dependent care (5).

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Neuropathic Orofacial Pain

Cited by 6 publications

References 96 publications

Orofacial pain in 1916 patients with early or moderate Parkinson disease

Orofacial pain in 1916 patients with early or moderate Parkinson disease

Orofacial Neuropathic Pain-Basic Research and Their Clinical Relevancies

Systemic considerations for orofacial neuropathy

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