Neuropathic low back pain

Audette, Joseph; Emenike, Emmanuel; Meleger, Alec L.

doi:10.1007/s11916-005-0058-8

Cited by 26 publications

(14 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Previous clinical studies have examined the effect of PRF on various types of pain (Audette et al, 2005;Kocoglu et al, 2002;Cahana et al, 2006;Malik and Benzon, 2007). In this study, we employed a rat model to demonstrate that PRF treatment reduces pain and increases withdrawal latency, as compared to conventional RF treatment.…”

Section: Discussionmentioning

confidence: 90%

Mechanisms of analgesic action of pulsed radiofrequency on adjuvant‐induced pain in the rat: Roles of descending adrenergic and serotonergic systems

Hagiwara

Iwasaka

Takeshima

et al. 2009

European Journal of Pain

159

122

View full text Add to dashboard Cite

Pulsed radiofrequency (PRF) has been reported to be effective in the treatment of several types of pain. The mechanism of action, however, is not well known. In a recent study, the antinociceptive effects of acute thermal pain were shown to be mediated via descending pain inhibitory pathways. In this study we observed an analgesic effect of PRF treatment in an adjuvant induced inflammatory pain model in rats. In this model, sciatic nerves were treated with PRF at 37 degrees and 42 degrees , which inhibited hyperalgesia in the inflammatory groups when compared to RF and sham treatment. This effect was attenuated after intrathecal administration of the alpha2-adrenoceptor antagonist yohimbine, the selective 5-HT3 serotonin receptor antagonist MDL72222, and the non-selective serotonin receptor antagonist methysergide. All three drugs were found to significantly inhibit the analgesic effect of PRF. The results suggest that the analgesic action of PRF involves the enhancement of noradrenergic and serotonergic descending pain inhibitory pathways.

show abstract

Section: Discussionmentioning

confidence: 90%

Mechanisms of analgesic action of pulsed radiofrequency on adjuvant‐induced pain in the rat: Roles of descending adrenergic and serotonergic systems

Hagiwara

Iwasaka

Takeshima

et al. 2009

European Journal of Pain

159

122

View full text Add to dashboard Cite

show abstract

“…In contrast, somatic referred pain is primarily associated with a dull or aching sensation. 3, 6, 21 . Contrary to our expectations, patients displaying a radicular pattern had nearly identical pain characteristics to those who did not.…”

Section: Discussionmentioning

confidence: 99%

Pain Characteristic Differences Between Subacute and Chronic Back Pain

Chanda

Alvin

Schnitzer

et al. 2011

The Journal of Pain

View full text Add to dashboard Cite

Back pain is commonly classified based on duration. There is currently limited information regarding differences in the clinical features of back pain between these duration-based groupings. Here, we compared the pain characteristics of patients with subacute (SBP; pain 6–16 weeks, n = 40) and chronic back pain (CBP; pain ≥ 1year, n = 37) recruited from the general population. CBP patients reported significantly higher pain intensity on the Visual Analogue Scale (VAS) compared to SBP patients. Based on this finding, we investigated group differences and their dependence on VAS for the Beck Depression Inventory (BDI), sensory and affective dimensions of the McGill Pain Questionnaire (MPQ-S and MPQ-A), Neuropathic Pain Scale (NPS) and the variability of spontaneous pain. Correction for VAS abolished significant group differences on the MPQ-S, MPQ-A and NPS. Only a significant difference in the variability of spontaneous pain was independent of VAS. Finally, whereas SBP patients displayed a higher incidence of unilateral pain radiating down the legs/buttocks, there was a shift towards more bilateral pain in CBP patients. In summary, SBP and CBP groups differ on three independent parameters: VAS ratings, pain location and temporal dynamics of spontaneous pain.

show abstract

“…For instances in which such other processes are not identified, back pain is assumed to occur on a mechanical basis, even when an exact underlying anatomic abnormality cannot be clearly detected. Many people with mechanical back pain also show a neuropathic presentation (traditionally classified as radiculopathy) manifest by tingling, burning, or numbness (Audette et al , 2005), or as pain ‘shooting’ into the distal affected part. Though commonly associated with acute disc herniation these neuropathic symptoms are also now commonly being identified in people with chronic low back pain.…”

Section: What Is Chronic Pain?mentioning

confidence: 99%

Towards a theory of chronic pain

Apkarian

Baliki

Geha

2009

Progress in Neurobiology

677

493

View full text Add to dashboard Cite

In this review we integrate recent human and animal studies from the viewpoint of chronic pain. First, we briefly review the impact of chronic pain on society and address current pitfalls of its definition and clinical management. Second, we examine pain mechanisms via nociceptive information transmission cephalad and its impact and interaction with the cortex. Third, we present recent discoveries on the active role of the cortex in chronic pain, with findings indicating that the human cortex continuously reorganizes as it lives in chronic pain. We also introduce data emphasizing that distinct chronic pain conditions impact on the cortex in unique patterns. Fourth, animal studies regarding nociceptive transmission, recent evidence for supraspinal reorganization during pain, the necessity of descending modulation for maintenance of neuropathic behavior, and the impact of cortical manipulations on neuropathic pain is also reviewed. We further expound on the notion that chronic pain can be reformulated within the context of learning and memory, and demonstrate the relevance of the idea in the design of novel pharmacotherapies. Lastly, we integrate the human and animal data into a unified working model outlining the mechanism by which acute pain transitions into a chronic state. It incorporates knowledge of underlying brain structures and their reorganization, and also includes specific variations as a function of pain persistence and injury type, thereby providing mechanistic descriptions of several unique chronic pain conditions within a single model.

show abstract

Neuropathic low back pain

Cited by 26 publications

References 34 publications

Mechanisms of analgesic action of pulsed radiofrequency on adjuvant‐induced pain in the rat: Roles of descending adrenergic and serotonergic systems

Mechanisms of analgesic action of pulsed radiofrequency on adjuvant‐induced pain in the rat: Roles of descending adrenergic and serotonergic systems

Pain Characteristic Differences Between Subacute and Chronic Back Pain

Towards a theory of chronic pain

Contact Info

Product

Resources

About