Neuroparacoccidioidomycosis: A 13-Year Cohort Study, Rio de Janeiro, Brazil

Macedo, Priscila Marques de; Falcão, Eduardo Mastrangelo Marinho; Freitas, Dayvison Francis Saraiva; Freitas, Andréa d’Avila; Coutinho, Ziadir Francisco; Muniz, Mauro de Medeiros; Zancopé‐Oliveira, Rosely Maria; Almeida‐Paes, Rodrigo; Silva, Marcus Tulius T.; Valle, Antônio Carlos Francesconi do

doi:10.3390/jof6040303

Cited by 4 publications

(6 citation statements)

References 23 publications

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“…The lungs are involved in more than 90% of the cases. However, central nervous system (CNS) involvement is reported in 10 to 27% of the cases and is mainly associated with pulmonary manifestations of the disease [11,12]. Both cases of chronic disease reported in this manuscript had disseminated lung lesions, with repercussions on the patients' respiratory capacity (permanent sequelae).…”

Section: Discussionmentioning

confidence: 76%

Paracoccidioidomycosis differential diagnosis: case series

Martins¹,

Silva²,

Ferreira³

et al. 2023

BJCR

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Paracoccidioidomycosis is a neglected disease and the most important systemic mycosis in Latin America. This fungal infection is directly linked to activities related to the rural environment, such as agriculture. Despite being a frequently diagnosed disease in Brazil, the real rates of prevalence and incidence are not estimated due to the non-mandatory notification of the disease, which was recently implemented in 2020. We report three interesting cases of Paracoccidioidomycosis in immunocompetent adults, with varied clinical manifestations.

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Section: Discussionmentioning

confidence: 76%

Paracoccidioidomycosis differential diagnosis: case series

Martins¹,

Silva²,

Ferreira³

et al. 2023

BJCR

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“…One more study was excluded after a review of the full text because of insufficient patient data. In conclusion, we included 34 manuscripts, with 104 new cases of NPCM 2,6,12,14–44 . We present the flow diagram in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…Many patients developed sequelae 44 . Delay in diagnosis can cause more sequelae 44 . Pedroso et al showed that approximately 63% of the patients had sequelae 12 .…”

Section: Discussionmentioning

confidence: 99%

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Systematic review of neuroparacoccidioidomycosis: The contribution of neuroimaging

Oliveira

Magri

Levin

et al. 2022

Mycoses

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Paracoccidioidomycosis (PCM) is a systemic fungal infection caused by thermally dimorphic fungi of two main species: Paracoccidioides brasiliensis (P. brasiliensis) and Paracoccidioides lutzii (P. lutzii). 1 The distribution of PCM includes subtropical regions and endemic countries with mild temperature and high and constant humidity. 2,3 It is considered the most important deep mycosis in Latin America, 4,5 especially in Brazil, responsible for the majority of reported cases. 3,6

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“…[ 2 ] Most of the cases presents with multifocal disease manifested as increased intracranial pressure and seizures. [ 3 ] The CNS involvement is due to hematogenic dissemination from peripheral foci. [ 15 ] PCM and neuroparacoccidioidomycosis (NPCM) are more prevalent in males in a 11:1 ratio.…”

Section: Introductionmentioning

confidence: 99%

Brain paracoccidioidomycosis in an immunosuppressed patient with systemic lupus erythematosus

Kamer

Pretto

Livramento

et al. 2021

Surgical Neurology International

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Background: Brain paracoccidioidomycosis (PCM) or neuroparacoccidioidomycosis (NPCM) is a fungal infection of the central nervous system (CNS) caused by Paracoccidioides brasiliensis, a dimorphic fungus. The CNS involvement is through bloodstream dissemination. The association between NPCM and systemic lupus erythematous (SLE) is rare. However, SLE patients are under risk of opportunistic infections given their immunosuppression status. Case Description: The aim of this case report is to present a 37-year-old female with diagnosis of SLE who presented with progressive and persistent headache in the past 4 months accompanied by the right arm weakness with general and neurologic examination unremarkable. The computerized tomography of the head showed left extra-axial parietooccipital focal hypoattenuation with adjacent bone erosion. The brain magnetic resonance imaging reported left parietooccipital subdural collection associated with focal leptomeningeal thickening with restriction to diffusion and peripheral contrast enhancement. The patient underwent a left craniotomy and dura mater biopsy showed noncaseous granulomatosis with multinucleated giant cells with rounded birefringent structures positive for silver stain, consistent with PCM. Management with itraconazole 200 mg daily was started with a total of 12 months of treatment, with patient presenting resolution of headache and right arm weakness. Conclusion: The diagnosis of NPCM is challenging and a high degree of suspicious should be considered in patients with persistent headache and immunosuppression.

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Neuroparacoccidioidomycosis: A 13-Year Cohort Study, Rio de Janeiro, Brazil

Cited by 4 publications

References 23 publications

Paracoccidioidomycosis differential diagnosis: case series

Paracoccidioidomycosis differential diagnosis: case series

Systematic review of neuroparacoccidioidomycosis: The contribution of neuroimaging

Brain paracoccidioidomycosis in an immunosuppressed patient with systemic lupus erythematosus

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