Neurons in rat medial prefrontal cortex show anticipatory rate changes to predictable differential rewards in a spatial memory task

Pratt, Wayne E.; Mizumori, Sheri J. Y.

doi:10.1016/s0166-4328(01)00204-2

Cited by 160 publications

(142 citation statements)

References 70 publications

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“…Perhaps the latter serves to transform PFC neurons into an ''up state'' of cell excitability so that it can readily incorporate subsequent information coming in from the indirect pathway. Consistent with this view, PFC neurons exhibit context-dependent anticipatory neural codes for reward information (Pratt and Mizumori, 2001). Also, PFC neural signaling has been found to be conditionally linked to hippocampal output since PFC cell firing can become phase locked to CA1 hippocampal theta rhythms and precession (Hyman et al, 2005;Jones and Wilson, 2005).…”

Section: Retrosplenial (Parietal) Cortex-hippocampal Interactionsmentioning

confidence: 82%

Hippocampal and neocortical interactions during context discrimination: Electrophysiological evidence from the rat

2007

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ABSTRACT:There is substantial evidence that hippocampus plays an important role in the processing of contextual information. Its specific role, however, remains unclear. One possibility is that single hippocampal neurons represent context information so that local circuits can construct representations of the current context, and the context that is expected based on past experience. Population codes derived from input by multiple local circuits may then engage match-mismatch algorithms that compare current and expected context information to determine the extent to which an expected context has changed. The results of such match-mismatch comparisons can be used to discriminate contexts. When context changes are detected, efferent messages may be passed on to connected neocortical areas so that informed "decisions" regarding future behavioral and cognitive strategies can be made. Here, a brief review describes evidence that a primary consequence of hippocampal processing is the discrimination of meaningful contexts. Then, the functional significance of neocortical circuits that likely receive hippocampal output messages are described in terms of their contribution to the control of ongoing behavioral and cognitive strategy, especially during active navigation. It is clear from this systems view that studies of spatial navigation continue to provide researchers with an excellent model of hippocampal-neocortical interactions during learning. V V C 2007 Wiley-Liss, Inc.

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Section: Retrosplenial (Parietal) Cortex-hippocampal Interactionsmentioning

confidence: 82%

Hippocampal and neocortical interactions during context discrimination: Electrophysiological evidence from the rat

2007

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“…These results are consistent with previous reports that showed anticipatory activity from the PFC in delayed working memory tasks. it is well documented that mPFC neurons in rats show sustained activity during the delay period of delay tasks [29,[39][40][41] . in nonhuman primates, the region responsible for working memory is mainly located in the caudal DLPFC [3] .…”

Section: Discussionmentioning

confidence: 99%

Anticipatory activity in rat medial prefrontal cortex during a working memory task

Bai

Liu

et al. 2012

Neurosci. Bull.

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Objective Working memory is a key cognitive function in which the prefrontal cortex plays a crucial role.This study aimed to show the firing patterns of a neuronal population in the prefrontal cortex of the rat in a working memory task and to explore how a neuronal ensemble encodes a working memory event. Methods Sprague-Dawley rats were trained in a Y-maze until they reached an 80% correct rate in a working memory task. Then a 16-channel microelectrode array was implanted in the prefrontal cortex. After recovery, neuronal population activity was recorded during the task, using the Cerebus data-acquisition system. Spatio-temporal trains of action potentials were obtained from the original neuronal population signals. Results During the Y-maze working memory task, some neurons showed significantly increased firing rates and evident neuronal ensemble activity. Moreover, the anticipatory activity was associated with the delayed alternate choice of the upcoming movement. In correct trials, the averaged pre-event firing rate (10.86 ± 1.82 spikes/ bin) was higher than the post-event rate (8.17 ± 1.15 spikes/bin) (P <0.05). However, in incorrect trials, the rates did not differ. Conclusion The results indicate that the anticipatory activity of a neuronal ensemble in the prefrontal cortex may play a role in encoding working memory events.

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“…It is possible that increased c-fos expression within the Infra-L by ethanol-or cocaineassociated stimuli is related to conditioned autonomic responses that are typically associated with drug cue exposure in humans (Sinha et al 2000;Stormark et al 1995). Additionally, the Infra-L is implicated in regulating impulsivity (Chudasama et al 2003), and manipulations interfering with Infra-L cortex function retard extinction of conditioned fear and increases the recovery of appetitive Pavlovian responses (Frysztak and Neafsey 1994;Pratt and Mizumori 2001;Rhodes and Killcross 2004). Thus, the Infra-L cortex warrants further attention with respect to a role in conditioned drug-seeking and relapse.…”

Section: Discussionmentioning

confidence: 99%

Distinct Patterns of Neural Activation Associated with Ethanol Seeking: Effects of Naltrexone

Dayas¹,

Liu²,

Simms³

et al. 2007

Biological Psychiatry

144

133

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Background-Alcoholism, like other substance abuse disorders, is a chronically relapsing condition. Compared with other abused drugs, however, little is known about the neural mechanisms mediating ethanol (EtOH)-craving and -seeking behavior leading to relapse. This study, therefore, was conducted to identify candidate brain regions that are recruited by an EtOH-associated contextual stimulus (S + ). A secondary objective was to determine whether EtOH S + -elicited neural recruitment patterns are modified by the opiate antagonist naltrexone (NTX), a compound that reduces cueinduced craving in alcoholics and attenuates ethanol seeking in animal models of relapse.

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Neurons in rat medial prefrontal cortex show anticipatory rate changes to predictable differential rewards in a spatial memory task

Cited by 160 publications

References 70 publications

Hippocampal and neocortical interactions during context discrimination: Electrophysiological evidence from the rat

Hippocampal and neocortical interactions during context discrimination: Electrophysiological evidence from the rat

Anticipatory activity in rat medial prefrontal cortex during a working memory task

Distinct Patterns of Neural Activation Associated with Ethanol Seeking: Effects of Naltrexone

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