Neurons, Chromaffin Cells and Membrane Fusion

On the Occurrence of Multiple Isoprenylated Cysteine Methyl Ester Hydrolase Activities in Bovine Adrenal Medulla

“…Isoprenylation/methylation of GTP-binding proteins generally includes a tripode of posttranslational reactions with in order of sequence: an isoprenylation step, an endoproteolytic cleavage, and the methylation of the C-terminal cysteine residue (7). For other G-proteins the posttranslation modification only includes isoprenylation, while a third group of G-proteins are directly methylated after isoprenylation without intermediate endoproteolysis.…”

“…Chromaffin cells of the adrenal medulla secrete upon activation catecholamines from LDV by controlled exocytosis (7). In this complex process many protein factors intervene including small GTP-binding proteins from the rab family.…”