Neurone-specific Enolase and Liver Metastasis in Small Cell Lung Cancer

Kanemoto, Kouji; Satoh, Hiroaki; Ishikawa, Hiroichi; Sekizawa, Kiyohisa

doi:10.1016/j.clon.2006.03.017

Cited by 9 publications

(9 citation statements)

References 4 publications

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“…The overexpression and elevated serum levels of phosphoglycerate kinase 1 are shown in pancreatic ductal adenocarcinoma (35). Moreover, serum ENO2 is considered to be a prognostic factor in small cell lung, breast, and prostrate cancer (36)(37)(38)(39). Finally, PKM2 seems to be a more sensitive marker than conventional tumor markers such as CEA and CA72-4 for the post-operative surveillance of gastrointestinal cancer (40)(41)(42)(43)(44).…”

Section: Discussionmentioning

confidence: 99%

Significance of the glycolytic pathway and glycolysis related-genes in tumorigenesis of human colorectal cancers

Yeh

Wang²,

Chung³

et al. 2008

Oncol Rep

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Abstract. We investigated gene expressions involved in the glycolytic pathways in colorectal cancer. The study was designed to use gene ontology and its relevant bioinformatics tools to analyze the microarray data obtained from CRC tissues and their corresponding normal tissues, in order to explore the correlation between the glycolytic metabolic pathway and possible pathogenesis of this disease. The overexpression of glycolysis-related genes was observed in over 76% of CRC tissues. In addition, we stimulated the SW480 and SW620 CRC cell lines with 15 mM D-(+)-glucose and 10 mM 2-deoxy-D-glucose respectively. The results indicate that the proliferation response of both the SW480 and SW620 cell lines increased remarkably with a time-dependent effect by D-(+)-glucose administration. In contrast, the proliferation response of both the SW480 and SW620 cell lines was significantly inhibited by 2-DG administration. Likewise, further analyses of the expression of related genes triggered by the D-(+)-glucose in vivo show that the activation process of these eight genes -GLUT1, HK1, GPI, GAPD, PGK1, PGK2, ENO2, PKM2 -prominently increased with a timedependent effect. In conclusion, this study demonstrates that the glycolytic pathway and glycolysis-related genes may play an important role in the tumorigenesis of CRC, but their molecular mechanisms need further investigation to verify this.

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Section: Discussionmentioning

confidence: 99%

Significance of the glycolytic pathway and glycolysis related-genes in tumorigenesis of human colorectal cancers

Yeh

Wang²,

Chung³

et al. 2008

Oncol Rep

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“…-Enolase (ENO1) is found in a variety of tissues, while -enolase (ENO3) is exclusively expressed in muscle tissues and -enolase (ENO2) is present in neurons and neuroendocrine tissues (Pancholi, 2001). ENO1 (EC 4.2.1.11) has been the focus of recent research owing to its multifunctional roles in diseases (Gerlt et al, 2005;Kim & Dang, 2005;Glasner et al, 2006;Liu & Shih, 2007) such as cancers (Katayama et al, 2006;Kanemoto et al, 2006;Gruber-Olipitz et al, 2004), autoimmune disorders (Mosca et al, 2006;Weleber et al, 2005;Kinloch et al, 2005;Gitlits et al, 2001), infections (Bergmann et al, 2005;Ehinger et al, 2004) and ischaemia (Anand & Stead, 2005). The disease-related roles of ENO1 mostly rely on its immunogenic properties (Fujii et al, 2005;Yoneda et al, 2007), DNA-binding ability (Al-Giery & Brewer, 1992;Subramanian & Miller, 2000;Wang et al, 2005) and plasmin(ogen) receptor function (Miles et al, 1991;Ehinger et al, 2004;Bergmann et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Structure of human α-enolase (hENO1), a multifunctional glycolytic enzyme

Kang

Jung

Kim

et al. 2008

Acta Crystallogr D Biol Crystallogr

101

113

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Aside from its enzymatic function in the glycolytic pathway, alpha-enolase (ENO1) has been implicated in numerous diseases, including metastatic cancer, autoimmune disorders, ischaemia and bacterial infection. The disease-related roles of ENO1 are mostly attributed to its immunogenic capacity, DNA-binding ability and plasmin(ogen) receptor function, which are significantly affected by its three-dimensional structure and surface properties, rather than its enzymatic activity. Here, the crystal structure of human ENO1 (hENO1) is presented at 2.2 A resolution. Despite its high sequence similarity to other enolases, the hENO1 structure exhibits distinct surface properties, explaining its various activities, including plasmin(ogen) and DNA binding.

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“…Compared with the patients with limited SCLC, patients suffering from extensive SCLC demonstrate significantly higher level of NSE. [13,14] At present, NSE serves as an important oncology indicator, particularly in the diagnosis and treatment of SCLC. [15] For suspected lung tumor patients, high NSE level (>100 ng/mL) suggests the high probability of SCLC, which should be discriminated from neuroendocrine tumor of other sites, liver tumor, lymphoma, and seminoma.…”

Section: Neuron-specific Enolasementioning

confidence: 99%

Advances in the study of serum tumor markers of lung cancer

Kang

2014

J Can Res Ther

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Lung cancer is among the most prevalently occurring carcinomas worldwide, and reducing lung cancer mortality depends on early detection, diagnosis, and treatment. Given the rapid development of molecular biology and modern techniques for diagnosis and treatment, the study of serum tumor markers has gained extensive application in early diagnosis, treatment effect monitoring, and prognosis evaluation. Serum tumor markers possess the advantages of easy detection, noninvasive operation, and cost-effectiveness. This article reviews the progress in the study of serum tumor markers of lung cancer.

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Neurone-specific Enolase and Liver Metastasis in Small Cell Lung Cancer

Cited by 9 publications

References 4 publications

Significance of the glycolytic pathway and glycolysis related-genes in tumorigenesis of human colorectal cancers

Significance of the glycolytic pathway and glycolysis related-genes in tumorigenesis of human colorectal cancers

Structure of human α-enolase (hENO1), a multifunctional glycolytic enzyme

Advances in the study of serum tumor markers of lung cancer

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