Neuronal transmission of hippocampal CA1 neurones is modulated by corticotropin-like intermediate lobe peptide [CLIP; ACTH(18–39)]

Effect of Corticotropin-Like Intermediate Lobe Peptide on Presynaptic and Postsynaptic Glutamate Receptors and Postsynaptic GABA Receptors in Rat Brain

“…Restraint stress is followed by a considerable increase in blood CLIP concentration (by 56%) and induction of sleep in rats [2]. As differentiated from ACTH, CLIP increases the amplitude of the population potential in the hippocampus (by 200%) that results in enhanced neuronal excitability [9].…”