Neuronal substrates of sensory gating within the human brain

Grünwald, Thomas; Boutros, Nashaat N.; Pezer, Nico; Oertzen, Tim J. von; Fernández, Guillén; Schaller, Carlo; Elger, Christian E.

doi:10.1016/s0006-3223(02)01673-6

Cited by 279 publications

(237 citation statements)

References 56 publications

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“…Prior to ESM, the patients underwent a P50 recording from their subdural electrode arrays. There was no overlap between this patient group and the group reported in an earlier publication (Grunwald et al 2003). All patients gave informed consent to the procedure.…”

Section: Patient Inclusionmentioning

confidence: 73%

“…In thirteen of the seventeen patients, cortical P50 could be recorded from subdural electrodes. Leads with P50 were identified with one exception in areas previously reported to show these responses in invasive recordings, namely the temporoparietal junction or posterior superior temporal gyrus, or (mid) frontal areas (Grunwald et al, 2003). Patient 9 with his P50-maximum in a motor cortex site is discussed in detail below.…”

Section: P50mentioning

confidence: 95%

“…For individual electrode coverage see table 2 and the examples presented in the figures. Intrahippocampal depth electrodes, implanted in some patients, did not enter into the analyses, because no P50 responses were present at these electrodes (see also discussion below and Grunwald et al, 2003).…”

Section: P50 Recordingmentioning

confidence: 99%

“…One was located bilaterally close to the primary auditory cortex, and another source in midfrontal regions. In a study with invasive P50 recordings from subdural strip and grid electrodes in epilepsy patients, Grunwald et al (2003) also found two major areas of P50 gating, one temporoparietal and one pre-and midfrontal. The insensitivity of the magnetoencephalography (MEG) for the detection of a frontal component (Weisser et al, 2001;Thoma et al, 2003) indicates that this frontal source may originate from deeper structures or have a radial orientation, as MEG is known to be relatively insensitive for both kinds of sources.…”

Section: Introductionmentioning

confidence: 96%

“…motor cortex, language cortex, primary sensory cortex. With the same array of chronically implanted electrodes, P50 sensory gating can be measured directly from the cortical surface (Grunwald et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

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Towards a functional topography of sensory gating areas: Invasive P50 recording and electrical stimulation mapping in epilepsy surgery candidates

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The filtering of sensory information, also referred to as "sensory gating", is impaired in various neuropsychiatric diseases. In the auditory domain, sensory gating is investigated mainly as a response decrease of the auditory evoked potential component P50 from one click to the second in a double click paradigm. In order to relate deficient sensory gating to anatomy, it is essential to identify the cortical structures involved in the generation of P50. However, the exact cerebral topography of P50 gating has remained largely unknown as yet. In a group of 17 patients with drug-resistant focal epilepsy, P50 was recorded invasively via subdural electrodes, and the topography of functionally indispensable ("eloquent") cortices was obtained by electrical stimulation mapping. These eloquent areas were involved in language, motor, and sensory functions. P50 could be identified in 13 patients in either temporal (n = 8) or midfrontal sites (n = 5). There were 6 occurrences (in 5 patients) of overlap of sites with maximal P50 responses and eloquent areas. Those were auditory (n = 1), supplementary sensorimotor (n = 3), primary motor (n = 1), and supplementary negative motor (n = 1). Results suggest that the early stage of sensory gating already involves a top-down modulation of sensory input by frontal areas.

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Section: Patient Inclusionmentioning

confidence: 73%

Section: P50mentioning

confidence: 95%

Section: P50 Recordingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Towards a functional topography of sensory gating areas: Invasive P50 recording and electrical stimulation mapping in epilepsy surgery candidates

Kurthen

Trautner

Rosburg

et al. 2007

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Self Cite

View full text Add to dashboard Cite

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Using EEG and MEG to Understand Brain Physiology in Alzheimer's Disease and Related Dementias

Ally

2011

The Handbook of Alzheimer's Disease and Other Dementias

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Intrinsic Infant Hippocampal Function Supports Inhibitory Processing

Guha,

Hunter,

Legget

et al. 2024

Developmental Psychobiology

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Impaired cerebral inhibition is commonly observed in neurodevelopmental disorders and may represent a vulnerability factor for their development. The hippocampus plays a key role in inhibition among adults and undergoes significant and rapid changes during early brain development. Therefore, the structure represents an important candidate region for early identification of pathology that is relevant to inhibitory dysfunction. To determine whether hippocampal function corresponds to inhibition in the early postnatal period, the present study evaluated relationships between hippocampal activity and sensory gating in infants 4–20 weeks of age (N = 18). Resting‐state functional magnetic resonance imaging was used to measure hippocampal activity, including the amplitude of low‐frequency fluctuations (ALFFs) and fractional ALFF. Electroencephalography during a paired‐stimulus paradigm was used to measure sensory gating (P50). Higher activity of the right hippocampus was associated with better sensory gating (P50 ratio), driven by a reduction in response to the second stimulus. These findings suggest that meaningful effects of hippocampal function can be detected early in infancy. Specifically, higher intrinsic hippocampal activity in the early postnatal period may support effective inhibitory processing. Future work will benefit from longitudinal analysis to clarify the trajectory of hippocampal function, alterations of which may contribute to the risk of neurodevelopmental disorders and represent an intervention target.

show abstract

Neuronal substrates of sensory gating within the human brain

Cited by 279 publications

References 56 publications

Towards a functional topography of sensory gating areas: Invasive P50 recording and electrical stimulation mapping in epilepsy surgery candidates

Towards a functional topography of sensory gating areas: Invasive P50 recording and electrical stimulation mapping in epilepsy surgery candidates

Using EEG and MEG to Understand Brain Physiology in Alzheimer's Disease and Related Dementias

Intrinsic Infant Hippocampal Function Supports Inhibitory Processing

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