“…The dynamic assembly of this membraneless foci in the cytoplasm, mediated by the overexpression of mRNA binding proteins, allows the temporary stop of translation initiation of selected mRNAs confined inside SGs, in order to prepare the cell for a future acute stress condition when mRNAs are rapidly released from SGs to codify the required proteins (Arribere et al 2011; Liu and Qian, 2014; Protter and Parker, 2016; Somasekharan et al, 2020). SGs consist in a core structure of key mRNA binding proteins and mRNAs, connected each other by strong interactions, surrounded by a less concentrated and more dynamic shell, in which proteins and mRNAs can be easily exchanged with other type of cytoplasmic foci, such as processing bodies (p-bodies) (García-Mauriño et al, 2017), where mRNAs undergo degradation, germ cell granules (Mukherjee and Mukherjee, 2021), for maternal mRNA storage during early development, and neuronal granules (Söhnel and Brandt, 2023), important for synaptic remodeling. The regulation of mRNA stability, therefore, plays a key role not only in stress responses but also in cell proliferation, differentiation, and development.…”