Neuronal Store-Operated Calcium Channels

Bouron, Alexandre

doi:10.1007/s12035-023-03352-5

Cited by 5 publications

(2 citation statements)

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“…Cultured hippocampal neurons prepared from a genetic mouse model of Alzheimer's disease are characterized by a mushroom spine loss that is rescued after the overexpression of TRPC6 channels or after a hyperforin treatment (H. Zhang et al, 2016). Hence, amyloid beta peptide 1-42 (A 42 ) oligomers downregulate the store-operated Ca 2+ entry (SOCE), a prominent neuronal Ca 2+ route (Bouron, 2023). The amplitude of SOCE is however restored when preincubating hippocampal neurons with 0.3 µM hyperforin (Popugaeva et al, 2019).…”

Section: Hyperforin and Alzheimer's Diseasementioning

confidence: 99%

Cellular neurobiology of hyperforin

Bouron

2023

Phytotherapy Research

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Hyperforin is a phloroglucinol derivative isolated from the medicinal plant Hypericum perforatum (St John's wort, SJW). This lipophilic biomolecule displays antibacterial, pro‐apoptotic, antiproliferative, and anti‐inflammatory activities. In addition, in vitro and in vivo data showed that hyperforin is a promising molecule with potential applications in neurology and psychiatry. For instance, hyperforin possesses antidepressant properties, impairs the uptake of neurotransmitters, and stimulates the brain derived neurotrophic factor (BDNF)/TrkB neurotrophic signaling pathway, the adult hippocampal neurogenesis, and the brain homeostasis of zinc. In fact, hyperforin is a multi‐target biomolecule with a complex neuropharmacological profile. However, one prominent pharmacological feature of hyperforin is its ability to influence the homeostasis of cations such as Ca2+, Na+, Zn2+, and H+. So far, the pathophysiological relevance of these actions is currently unknown. The main objective of the present work is to provide an overview of the cellular neurobiology of hyperforin, with a special focus on its effects on neuronal membranes and the movement of cations.

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Section: Hyperforin and Alzheimer's Diseasementioning

confidence: 99%

Cellular neurobiology of hyperforin

Bouron

2023

Phytotherapy Research

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“…In excitable cells, frequent stimulation of voltage-gated and ligand-gated membrane channels allows for multiple modes of Ca 2+ entry possibly rendering STIM/Orai SOCE redundant. However, evidence of SOCE in excitable cells has mounted over the years ( Bouron, 2023 ). Indeed, SOCE was identified in excitable cells well before the molecular mechanism of SOCE through STIM/Orai was elucidated in non-excitable cells ( Emptage et al, 2001 ; Baba et al, 2003 ).…”

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confidence: 99%

IP₃Rs and nSOCE—Tied Together at Two Ends

Hasan

2024

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All living organisms need to respond appropriately to changes in the extracellular milieu. Cellular mechanisms that enable such responses evolved in parallel with organismal complexity and intracellular Ca2+ signaling is one such mechanism where extracellular signals received at the cell membrane communicate with endoplasmic reticular stores of Ca2+, to stimulate appropriate Ca2+-mediated changes in cellular physiology. The amplitude and dynamics of endoplasmic reticulum (ER)-Ca2+ release in response to extracellular signals determines the nature of the cellular response. An understanding of how ER-Ca2+ channels might regulate cellular Ca2+ signaling in different cell types is lacking. In a recent paper, this question has been addressed in the context of neurons ( Chakraborty et al., 2023 ) and the implications of these new findings are discussed here.

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N,N,N′,N′-Tetrakis(2-pyridylmethyl)ethylenediamine induces endothelium-dependent hyperpolarization-mediated vasorelaxation via store-operated calcium entry mechanism in healthy and intestinal inflammatory mice

Zhang,

Rong,

Wang

et al. 2024

Heliyon

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Neuronal Store-Operated Calcium Channels

Cited by 5 publications

References 322 publications

Cellular neurobiology of hyperforin

Cellular neurobiology of hyperforin

IP₃Rs and nSOCE—Tied Together at Two Ends

N,N,N′,N′-Tetrakis(2-pyridylmethyl)ethylenediamine induces endothelium-dependent hyperpolarization-mediated vasorelaxation via store-operated calcium entry mechanism in healthy and intestinal inflammatory mice

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Neuronal Store-Operated Calcium Channels

Cited by 5 publications

References 322 publications

Cellular neurobiology of hyperforin

Cellular neurobiology of hyperforin

IP3Rs and nSOCE—Tied Together at Two Ends

N,N,N′,N′-Tetrakis(2-pyridylmethyl)ethylenediamine induces endothelium-dependent hyperpolarization-mediated vasorelaxation via store-operated calcium entry mechanism in healthy and intestinal inflammatory mice

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IP₃Rs and nSOCE—Tied Together at Two Ends