Neuronal potassium channel activity triggers initiation of mRNA translation through binding of translation regulators
Taylor J. Malone,
Jing Wu,
Yalan Zhang
et al.
Abstract:SUMMARYNeuronal activity stimulates mRNA translation crucial for learning and development. While FMRP (Fragile X Mental Retardation Protein) and CYFIP1 (Cytoplasmic FMR1 Interacting Protein 1) regulate translation, the mechanism linking translation to neuronal activity is not understood. We now find that translation is stimulated when FMRP and CYFIP1 translocate to the potassium channel Slack (KCNT1, Slo2.2). When Slack is activated, both factors are released from eIF4E (Eukaryotic Initiation Factor 4E), where… Show more
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