Neuronal Per Arnt Sim (PAS) Domain Protein 4 (NPAS4) Regulates Neurite Outgrowth and Phosphorylation of Synapsin I

Yun, Jaesuk; Nagai, Taku; Furukawa‐Hibi, Yoko; Kuroda, Kensuke; Kaibuchi, Kozo; Greenberg, Michael E.; Yamada, Kiyofumi

doi:10.1074/jbc.m112.413310

Cited by 35 publications

(27 citation statements)

References 48 publications

(57 reference statements)

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“…Neuronal PAS domain protein 4 (Npas4) is a transcription factor encoded by a neuronal activity-dependent immediate-early gene and is required for activity-dependent inhibitory synapse development, activity-dependent changes in inhibitory synaptic connectivity, and neurite outgrowth [62][63][64]. Npas4 knockdown selectively reduces the number of inhibitory synapses formed on both the soma and dendrites, suggesting that Npas4 may regulate the development of inhibitory synapses originating from multiple interneurons [62].…”

Section: Schemaɵcs Of Inhibitory Synapse Organizersmentioning

confidence: 99%

The balancing act of GABAergic synapse organizers

Choii

2015

Trends in Molecular Medicine

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Section: Schemaɵcs Of Inhibitory Synapse Organizersmentioning

confidence: 99%

The balancing act of GABAergic synapse organizers

Choii

2015

Trends in Molecular Medicine

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“…To test this hypothesis, we conducted in vitro experiments to examine whether 5-HT 2A receptor expressed in cultured neuronal cells was internalized in response to FSS. Based on our simulation mentioned above, we applied pulsatile FSS with an average magnitude of 0.91 Pa to Neuro2A cells, which exhibit neuronal phenotypes and morphology (Goshima et al, 1993;Yun et al, 2013), using a system we previously reported (Yoshino et al, 2013). Similar to what was observed after 5-HT administration, FSS application (0.91 Pa, 0.5 Hz, 30 min) caused internalization of 5-HT 2A receptors expressed in Neuro2A cells ( Figure 3A).…”

Section: Fss On Neuronal Cells Induces 5-ht 2a Receptor Internalizationmentioning

confidence: 67%

Mechanical Regulation Underlies Effects of Exercise on Serotonin-Induced Signaling in the Prefrontal Cortex Neurons

et al. 2020

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Mechanical forces are known to be involved in various biological processes. However, it remains unclear whether brain functions are mechanically regulated under physiological conditions. Here, we demonstrate that treadmill running and passive head motion (PHM), both of which produce mechanical impact on the head, have similar effects on the hallucinogenic 5-hydroxytryptamine (5-HT) receptor subtype 2A (5-HT 2A) signaling in the prefrontal cortex (PFC) of rodents. PHM generates interstitial fluid movement that is estimated to exert shear stress of a few pascals on cells in the PFC. Fluid shear stress of a relevant magnitude on cultured neuronal cells induces ligand-independent internalization of 5-HT 2A receptor, which is observed in mouse PFC neurons after treadmill running or PHM. Furthermore, inhibition of interstitial fluid movement by introducing polyethylene glycol hydrogel eliminates the effect of PHM on 5-HT 2A receptor signaling in the PFC. Our findings indicate that neuronal cell function can be physiologically regulated by mechanical forces in the brain.

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“…The neuronal per arnt sim domain protein 4 (NPAS4) mRNA expression was decreased in the female rat barrel cortex under conditions of input‐deprivation. NPAS4 has been implicated in the development of inhibitory synapses as well as neurite outgrowth (Lin et al, ; Yun et al, ). There is a direct relationship between neuronal activity and NPAS4 expression, which is mediated through intracellular calcium.…”

Section: Discussionmentioning

confidence: 99%

Female rat transcriptome response to infraorbital nerve transection differs from that of males: RNA‐seq

Orczyk

Batka

Gore

et al. 2016

J of Comparative Neurology

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The effects of infraorbital nerve (ION) transection on gene expression in the adult female rat barrel cortex were investigated using RNA sequencing. After a 24-hour survival duration, 28 genes were differentially regulated by ION transection. Differentially expressed genes suggest microglial activity, increased retrograde ciliary transport, and a decrease in inhibition. These changes may be functionally comparable to changes in the male barrel cortex, where changes in genes related to morphology, neuronal activity, and neuronal excitability were observed. However, the patterns in changes in gene expression are vastly different between male and female rats. The results strongly caution against the practice of generalizing data from one sex to both sexes. This cautionary note has potentially profound implications for a range of research lines, including substance abuse and stress, both research domains in which subjects have been predominantly males. Future research needs to employ sex as a classification variable, as sex differences can generally be expected. Future research is also needed to confirm that changes in gene expression observed with RNA-seq correlate with changes in protein expression. J. Comp. Neurol. 525:140-150, 2017. © 2016 Wiley Periodicals, Inc.

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Neuronal Per Arnt Sim (PAS) Domain Protein 4 (NPAS4) Regulates Neurite Outgrowth and Phosphorylation of Synapsin I

Cited by 35 publications

References 48 publications

The balancing act of GABAergic synapse organizers

The balancing act of GABAergic synapse organizers

Mechanical Regulation Underlies Effects of Exercise on Serotonin-Induced Signaling in the Prefrontal Cortex Neurons

Female rat transcriptome response to infraorbital nerve transection differs from that of males: RNA‐seq

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