Neuronal pathways involved in abdominal surgery-induced gastric ileus in rats

Barquist, Erik; Bonaz, Bruno; Martı́nez, Vicente; Rivier, Jean; Mj, Zinner; Taché, Yvette

doi:10.1152/ajpregu.1996.270.4.r888

Cited by 71 publications

(100 citation statements)

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“…Injection of α-helical CRF 9-41 , d-Phe 12 CRF 12-41 , astressin, or astressin-B into the CSF or PVN completely prevented the delayed gastric emptying induced by various psychological, physical, visceral, immunological, or chemical stressors, including swim stress, restraint, abdominal or cranial surgery, peritoneal irritation with 0.6% acetic acid, systemic or brain injection of IL-1β, and exposure to ether anesthesia (5,63,66). Consistent with this, various stressors, including abdominal surgery and peripheral administration of IL-1β, activate neurons that express CRF and upregulate levels of mRNA encoding CRF in the PVN (67)(68)(69)(70). Likewise, urocortin 1, urocortin 2, and urocortin 3 are present in the PVN, and expression of the urocortins is upregulated during stress (49,71,72).…”

Section: Link Between Crf Receptors In the Brain And Stressrelated Almentioning

confidence: 79%

Corticotropin-releasing factor receptors and stress-related alterations of gut motor function

Taché¹,

Bonaz²

2007

J. Clin. Invest.

310

285

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Over the past few decades, corticotropin-releasing factor (CRF) signaling pathways have been shown to be the main coordinators of the endocrine, behavioral, and immune responses to stress. Emerging evidence also links the activation of CRF receptors type 1 and type 2 with stress-related alterations of gut motor function. Here, we review the role of CRF receptors in both the brain and the gut as part of key mechanisms through which various stressors impact propulsive activity of the gastrointestinal system. We also examine how these mechanisms translate into the development of new approaches for irritable bowel syndrome, a multifactorial disorder for which stress has been implicated in the pathophysiology. Stress and gut motor functionA real or perceived threat to the homeostasis of mammalian organisms, originating internally or externally, triggers adaptive stress responses that affect behavior, as well as endocrine, immune, autonomic, and visceral functions (1, 2). Regarding effects in visceral functions in particular, early seminal investigations reported by Cannon and by Almy and colleagues provided clear evidence that emotional stress impacts gastric and colonic motor activity in healthy volunteers and cats (3, 4). Subsequent studies established that delayed emptying of the stomach is the most common response evoked by various acute stressors in both experimental animals and healthy human subjects (5). By contrast, in the colon, various stressors (including anxiety, dichotomous listening, fear, intermittent hand immersion in cold water, and stressful interviews) increase colonic motility in healthy subjects (5). Similarly, in rodents and dogs, stressors as diverse as open-field test, fear conditioning, loud sound, restraint, cold exposure, water avoidance, inescapable foot or tail shocks, and increased levels of cytokines induced by endotoxins stimulate propulsive colonic motor function (2, 5-7). The autonomic nervous system provides a peripheral neuronal network by which the effects of stress can be rapidly imposed on gut function. These are mediated through the sympathetic, and vagal and pelvic parasympathetic innervation of the enteric nervous system embedded into the muscular layers of the gut (8).It is becoming increasingly recognized that these interconnected brain-gut neuronal pathways activated during stress have relevance in the pathophysiology of functional bowel disorders (9-11). In particular, various stressors in the form of early life trauma, sexual abuse, maternal neglect, fear conditioning, lifethreatening events, and enteric infection have an important role in the etiology of irritable bowel syndrome (IBS), which is characterized by altered bowel movements, bloating, and visceral pain (10-13). Cyclic vomiting syndrome is another brain-gut disorder manifested by recurrent, stereotyped episodes of nausea and vomiting in the pediatric population, which is triggered by stressors related to heightened emotional state, fasting, exercise, and infection in 80% of the patients (14).A big step forward...

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Section: Link Between Crf Receptors In the Brain And Stressrelated Almentioning

confidence: 79%

Corticotropin-releasing factor receptors and stress-related alterations of gut motor function

Taché¹,

Bonaz²

2007

J. Clin. Invest.

310

285

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“…Indeed, there is good evidence that capsaicin can increase the rate of gastric motility in humans (Gonzalez et al, 1998;Debreceni et al, 1999). This also implies a therapeutic potential for TRPV1 agonists in the pharmacotherapy of gastroparesis (Barquist et al, 1996).…”

Section: E Transient Receptor Potential Channels In Obesity and Metamentioning

confidence: 99%

Transient Receptor Potential Channels as Drug Targets: From the Science of Basic Research to the Art of Medicine

2014

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“…Intraperitoneal capsaicin treatment 2 days before abdominal surgery with subsequent ablation of visceral afferents resulted in immediate recovery of postoperative gastrointestinal motility, indicating an important role for visceral afferent nerve fibers in the mediation of postoperative ileus [34]. Based on these observations, it was suggested that capsaicin may be used to treat postoperative ileus [17] and that acutely impaired neuromuscular function during postoperative ileus may be due to the activation of inhibitory neural reflexes [1,7].…”

Section: Introductionmentioning

confidence: 99%

Systemic capsaicin inhibits neuronal activation in the brainstem during postoperative ileus in the mouse

Mueller

Kampitoglou

Glatzle

et al. 2006

Langenbecks Arch Surg

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Neuronal pathways involved in abdominal surgery-induced gastric ileus in rats

Cited by 71 publications

References 0 publications

Corticotropin-releasing factor receptors and stress-related alterations of gut motor function

Corticotropin-releasing factor receptors and stress-related alterations of gut motor function

Transient Receptor Potential Channels as Drug Targets: From the Science of Basic Research to the Art of Medicine

Systemic capsaicin inhibits neuronal activation in the brainstem during postoperative ileus in the mouse

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