2020
DOI: 10.3389/fcimb.2020.583899
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Abstract: There is a growing consensus that the balance between the persistence of infection and the host immune response is crucial for chronification of Chagas heart disease. Extrapolation for chagasic megacolon is hampered because research in humans and animal models that reproduce intestinal pathology is lacking. The parasite-host relationship and its consequence to the disease are not well-known. Our model describes the temporal changes in the mice intestine wall throughout the infection, parasitism, and the develo… Show more

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Cited by 10 publications
(15 citation statements)
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References 106 publications
(146 reference statements)
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“…The chronic digestive disease consists of megaesophagus or megacolon or both [ 109 ]. The main pathogenetic mechanism involved in the chronic digestive disease is the denervation of the enteric nervous system [ 109 , 117 ]. Administration of ASA was found to be neuro-protective in mice models [ 118 , 119 ], leading to an increase in the number of nitrergic neurons and preventing hypertrophy of the esophagus [ 118 , 119 ] and the colon [ 113 ].…”
Section: Resultsmentioning
confidence: 99%
“…The chronic digestive disease consists of megaesophagus or megacolon or both [ 109 ]. The main pathogenetic mechanism involved in the chronic digestive disease is the denervation of the enteric nervous system [ 109 , 117 ]. Administration of ASA was found to be neuro-protective in mice models [ 118 , 119 ], leading to an increase in the number of nitrergic neurons and preventing hypertrophy of the esophagus [ 118 , 119 ] and the colon [ 113 ].…”
Section: Resultsmentioning
confidence: 99%
“…Nevertheless, denervation and other features of nascent enteropathy have been described in mouse models at the histological level 14,[29][30][31][32] . Delayed transit has also been reported 33,34 but neither the GI region involved nor associations with infection dynamics were determined.…”
Section: Discussionmentioning
confidence: 99%
“…T. cruzi infected mice do not develop advanced digestive megasyndromes resembling those in humans, but these are late stage manifestations that usually take many years to develop. Nevertheless, denervation and other features of nascent enteropathy have been described in several mouse models at the histological level [27,[41][42][43][44][45]. Delayed transit has also been reported [44,46,47], but neither the GI region involved, nor associations with infection dynamics have been determined.…”
Section: Plos Pathogensmentioning
confidence: 99%