Neuronal organization of the reticular nucleus of the thalamus in adult humans

Berezhnaya, L. A.

doi:10.1007/s11055-006-0049-1

Cited by 3 publications

(3 citation statements)

References 4 publications

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“…At the spacious rostral pole of TRN, neurons have round perikarya and multipolar dendrites. In the cramped central-posterior TRN sectors neurons have elongated and flattened perikarya and sparsely branched dendrites (Nakatani, 1993; Ulfig et al, 1998; Berezhnaya, 2006). These variations reflect the impact of mechanical factors on the morphology of neurons, as in other brain regions (Feldman and Peters, 1978; Hilgetag and Barbas, 2006).…”

Section: Discussionmentioning

confidence: 99%

Pathways for Emotions and Attention Converge on the Thalamic Reticular Nucleus in Primates

Zikopoulos¹,

Barbas²

2012

J. Neurosci.

164

137

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How do emotional events readily capture our attention? To address this question we used neural tracers to label pathways linking areas involved in emotional and attentional processes in the primate brain (Macaca mulatta). We report that a novel pathway from the amygdala, the brain's emotional center, targets the inhibitory thalamic reticular nucleus (TRN), a key node in the brain's attentional network. The amygdalar pathway formed unusual synapses close to cell bodies of TRN neurons, and had more large and efficient terminals than pathways from the orbitofrontal cortex and the thalamic mediodorsal nucleus, which similarly innervated extensive TRN sites. The robust amygdalar pathway provides a mechanism for rapid shifting of attention to emotional stimuli. Acting synergistically, pathways from the amygdala and orbitofrontal cortex provide a circuit for purposeful assessment of emotional stimuli. The different pathways to TRN suggest distinct mechanisms of attention to external and internal stimuli that may be differentially disrupted in anxiety and mood disorders and may be selectively targeted for therapeutic interventions.

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Section: Discussionmentioning

confidence: 99%

Pathways for Emotions and Attention Converge on the Thalamic Reticular Nucleus in Primates

Zikopoulos¹,

Barbas²

2012

J. Neurosci.

164

137

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“…B. Scheibel [29] described in the TRN a population of multipolar neurons of various sizes, similar to the ones in the reticular formation in the brainstem. Berezhnaya [5] describes in detail the neuronal organization of the TRN in the human using silver nitrate impregnation by the Golgi method. Using the Ortolux (Leitz, Germany) microscope, in this study the authors investigated and drew all the sections in sagittal and frontal planes.…”

Section: Introductionmentioning

confidence: 99%

“…Prior studies on cats report that the dendrites of the TRN neurons form a local inhibitory internal network [13]. Berezhnaya [5] describes in detail the morphology of the TRN neurons, and according to this study when comparing the TRN cells in the human and the other species it can be found that the classical aspiny neurons of types R1 and R2 are indeed identical [21]. Apart from these cells, this study reports that in the human TRN is also found another type of R1 reticular neurons with spinelike processes on their bodies and the proximal parts of their dendrites.…”

Section: Introductionmentioning

confidence: 99%

Morphology of NOS-immunoreactive Neurons in the Human Thalamic Reticular Nucleus and its Clinical Implications

Malinova¹

2022

AMA

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Nitric oxide (NO) is an important signaling molecule that is widely distributed in the central and peripheral nervous system. The aim of this study was to determinate the morphology of the different neurons scattered in the thalamic reticular nucleus (TRN) and close to it, i.e. the internal capsule and external medullary lamina of the thalamus. We discuss the main functions pertaining to the modulation of synaptic transmission in the TRN, the internal capsule and external medullary lamina, the targets of nitrergic signaling, and the involvement of nitric oxide (NO) in the different neurodegenerative diseases, psychiatric disorders, and sensory neurotransmission in the thalamocortical and corticothalamic connections passing through the TRN.

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Circuits for Multisensory Integration and Attentional Modulation Through the Prefrontal Cortex and the Thalamic Reticular Nucleus in Primates

Zikopoulos

Barbas²

2007

Reviews in the Neurosciences

131

111

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Converging evidence from anatomic and physiologic studies suggests that the interaction of highorder association cortices with the thalamus is necessary to focus attention on a task in a complex environment with multiple distractions. Interposed between the thalamus and cortex, the inhibitory thalamic reticular nucleus intercepts and regulates communication between the two structures. Recent findings demonstrate that a unique circuitry links the prefrontal cortex with the reticular nucleus and may underlie the process of selective attention to enhance salient stimuli and suppress irrelevant stimuli in behavior. Unlike other cortices, some prefrontal areas issue widespread projections to the reticular nucleus, extending beyond the frontal sector to the sensory sectors of the nucleus and may influence the flow of sensory information from the thalamus to the cortex. Unlike other thalamic nuclei, the mediodorsal nucleus, which is the principal thalamic nucleus for the prefrontal cortex, has similarly widespread connections with the reticular nucleus. Unlike sensory association cortices, some terminations from prefrontal areas to the reticular nucleus are large, suggesting efficient transfer of information. We propose a model showing that the specialized features of prefrontal pathways in the reticular nucleus may allow selection of relevant information and override distractors, in processes that are deranged in schizophrenia.

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Neuronal organization of the reticular nucleus of the thalamus in adult humans

Cited by 3 publications

References 4 publications

Pathways for Emotions and Attention Converge on the Thalamic Reticular Nucleus in Primates

Pathways for Emotions and Attention Converge on the Thalamic Reticular Nucleus in Primates

Morphology of NOS-immunoreactive Neurons in the Human Thalamic Reticular Nucleus and its Clinical Implications

Circuits for Multisensory Integration and Attentional Modulation Through the Prefrontal Cortex and the Thalamic Reticular Nucleus in Primates

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