Neuronal nitric oxide synthases in the pathogenesis of metabolic syndrome

Abstract

The study of the molecular mechanisms of metabolic syndrome (MS) and its complications are among the most acute problems of modern endocrinology. Functional changes in the expression, activity, and regulatory properties of neuronal NO synthase (nNOS), which catalyzes the formation of the most important secondary mediator, nitric oxide (NO), and its dependent NO/cGMP signaling pathways in the brain, myocardium, and skeletal muscles, play a key role among the molecular causes of MS. In the brain, nNOS is associated with NMDA receptors, the hyperactivation of which in MS leads to excessive stimulation of nNOS and hyperproduction of NO, which leads to NO-induced damage to neurons and disruption of the central regulation of physiological processes and neurodegeneration. In the myocardium with MS, there are changes in the expression and localization of nNOS, as well as its functional interaction with cytoskeletal proteins, which leads to disorders of myocardial contraction and hypertrophy. In skeletal muscles, nNOS controls their contraction, oxidative metabolism, is involved in the regulation of vascular relaxation, and also participates in the regulation of glucose transport. A decrease in the expression and activity of nNOS, as well as dysregulation of its activity in MS, cause disturbances of these processes and make a significant contribution to the development of insulin resistance and deterioration of glucose homeostasis. Thus, nNOS can be considered an important therapeutic target in the treatment of MS and other metabolic disorders, as well as to prevent their complications from the nervous and cardiovascular systems and the musculoskeletal system.

State of Endothelial Vasomotor Function in Children with Arterial Hypertension

“…nNOS (161 кДа), состоящая из 1434 аминокислотных остатков, экспрессируется в основном в нейронах и продуцирует NO как клеточную сигнальную молекулу [6,21]. В настоящее время описано пять вариантов nNOS (α, β, γ, μ и nNOS-2), которые генерируются в результате альтернативного сплайсинга [9]. iNOS (131 кДа) содержит 1153 аминокислотных остатка, локализуется в иммунных клетках и синтезирует оксид азота в качестве предшественника к цитотоксическим свободным радикалам для защиты от вторжения бактерий [6,21].…”