Neuronal networks that regulate gonadotropin-releasing hormone/luteinizing hormone secretion during undernutrition: evidence from sheep

Merkley, Christina M.; Shuping, Sydney; Nestor, Casey C

doi:10.1016/j.domaniend.2020.106469

Cited by 11 publications

(6 citation statements)

References 55 publications

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“…Sheep play a crucial role in research associated with the discipline of neuroendocrinology [Figure 1], which orchestrates and regulates vital functions and physiological behaviors through the constant interactions between the nervous and endocrine systems. Neuroendocrinological research topics include the suppression of reproductive activity due to stress, undernutrition, and inflammation [100][101][102][103] , and seasonal sheep neuroendocrine regulation [104,105] . Their outcomes assist in understanding mechanisms governing neuroendocrine human and ovine biology.…”

Section: Neuroendocrinologal Researchmentioning

confidence: 99%

A one-health approach to using sheep in research, with a focus on neuroscience studies

Chatzimanou,

Tsingotjidou

2023

One Health Implement Res

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Sheep have been an important animal for both academic and basic sciences education, with a positive impact on the public health sector and, subsequently, One Health. This review presents the impact of sheep on research with a specific focus on neuroscience studies. Disorders, as well as neuroendocrine and environmental factors affecting the brain, the spinal cord, and the peripheral nervous system, are selected, and relevant research and sheep models mimicking human diseases are described. The review discusses various sheep models, encompassing prion, Parkinson’s, Alzheimer’s, Huntington’s disease, and neuronal ceroid lipofuscinoses (Batten Disease), along with ischemic stroke. Sheep play a pivotal role in elucidating the pathogenesis and/or treatment for the aforementioned diseases. Furthermore, this research is underpinned by solid neuroanatomy knowledge. Consequently, we outline the main reasons why sheep are such robust research models. In conclusion, we demonstrate the important role that sheep models fulfill in advancing the mission of the One Health Initiative.

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Section: Neuroendocrinologal Researchmentioning

confidence: 99%

A one-health approach to using sheep in research, with a focus on neuroscience studies

Chatzimanou,

Tsingotjidou

2023

One Health Implement Res

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“…2). In undernourished conditions, the activity levels of orexigenic factors are increased, whereas those of anorexigenic factors are decreased, to promote feeding behavior [35,36]. Concurrently, these alterations suppress GnRH secretion, and temporarily attenuate reproductive functions to prioritize the survival of individual over survival of species [35,36].…”

Section: Appetite Regulatory Factorsmentioning

confidence: 99%

“…Kisspeptin in ARC and that in anteroventral periventricular nucleus (AVPV) mediate negative positive feedback signals from estrogen, respectively, and they regulate pulsatile secretion of GnRH and GnRH surges to promote normal sexual maturation and regular ovulation [14,15,81]. It has been shown that leptin plays some roles in the regulation of kisspeptin in well-nourished condition, i.e., leptin stimulates both sets of kisspeptin neurons via neurons in the ventral premammillary nucleus [35,36]. Leptin also suppresses the action of AgRP and NPY neurons, those are suppressive factors of kisspeptin and GnRH in well-nourished condition.…”

Section: Kisspeptinmentioning

confidence: 99%

Effects of undernutrition and low energy availability on reproductive functions and their underlying neuroendocrine mechanisms

et al. 2022

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It has been well established that undernutrition and low energy availability disturb female reproductive functions in humans and many animal species. These reproductive dysfunctions are mainly caused by alterations of some hypothalamic factors, and consequent reduction of gonadotrophin-releasing hormone (GnRH) secretion. Evidence from literature suggests that increased activity of orexigenic factors and decreased activity of anorexigenic/satiety-related factors in undernourished conditions attenuate GnRH secretion in an integrated manner. Likewise, the activity of kisspeptin neurons, which is a potent stimulator of GnRH, is also reduced in undernourished conditions. In addition, it has been suggested that gonadotrophininhibitory hormone, which has anti-GnRH and gonadotrophic effects, may be involved in reproductive dysfunctions under several kinds of stress conditions. It should be remembered that these alterations, i.e., promotion of feeding behavior and temporary suppression of reproductive functions, are induced to prioritize the survival of individual over that of species, and that improvements in metabolic and nutritional conditions should be considered with the highest priority.

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“…Accordingly, the energy status affects every aspect of ruminant reproduction. Studies have shown that limiting energy can disrupt the reproductive process [1,2], while temporarily providing an excess of energy, a practice known as flushing, has been proven to increase the ovulation rate and lambing performance in sheep [3,4]. It appears evident that energy status is acutely monitored through endocrine and nutritional signals, which are evaluated both centrally and peripherally to modulate reproductive function [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Unveiling the Role of IGF-I in Fertility: Effect of Long-Acting Bovine Somatotropin (bST) on Terminal Follicular Development and Fertility during an Annual Reproductive Cycle in Sheep

Cox,

Carrasco,

Navarrete

et al. 2024

Animals

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The study aimed to assess the effect of long-acting bST treatment, in a dose that only increases IGF-I plasma concentrations, on ovarian and fertility markers of estrous synchronized ewes that were fed to keep their bodyweight. Three experiments were designed to evaluate this effect: in Experiment 1, 18 ewes were distributed in groups (bST 0, 30, 50 mg) to measure plasma IGF-I and insulin for 15 days; in Experiment 2, 92 ewes (5 replicates) in two groups (0 and 30 mg bST) were synchronized using a 6-day progesterone protocol during the breeding season to assess the effect of bST on follicular and luteal performances, estrous and ovulation, and fertility after mating. In Experiment 3, 50 ewes (3 replicates) were used to repeat the study before but during anestrus. Results indicate that 50 mg bST increased IGF-I and insulin plasma concentrations, but 30 mg bST only increased IGF-I concentrations; and that only during the breeding season did 30 mg bST increase the number of lambs born and the reproductive success of ovulatory-sized follicles compared to controls. This occurred without it affecting any other reproductive marker. In conclusion, 30 mg bST treatment may improve oocyte competence for fertility during the breeding season.

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Neuronal networks that regulate gonadotropin-releasing hormone/luteinizing hormone secretion during undernutrition: evidence from sheep

Cited by 11 publications

References 55 publications

A one-health approach to using sheep in research, with a focus on neuroscience studies

A one-health approach to using sheep in research, with a focus on neuroscience studies

Effects of undernutrition and low energy availability on reproductive functions and their underlying neuroendocrine mechanisms

Unveiling the Role of IGF-I in Fertility: Effect of Long-Acting Bovine Somatotropin (bST) on Terminal Follicular Development and Fertility during an Annual Reproductive Cycle in Sheep

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