Neuronal mitochondria-targeted delivery of curcumin by biomimetic engineered nanosystems in Alzheimer's disease mice

Gao, Chun‐Hong; Wang, Yuli; Sun, Jiejie; Yang, Han Na; Gong, Wenbin; Li, Yang; Yang, Feng; Wang, Hao; Yang, Meiyan; Li, Zhiping; Yang, Yang; Gao, Chunsheng

doi:10.1016/j.actbio.2020.03.029

Cited by 92 publications

(68 citation statements)

References 50 publications

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“…Recently, Gao et al. 85 reported a strategy that combined HSA binding and RBC membrane engineering. RBC membrane-camouflaged HSA NPs were constructed to delivery antioxidants for relieving Alzheimerʹs disease symptoms, providing long-term circulation and improved biocompatibility.…”

Section: Existing Strategies To Manipulate the Drug In Vivo Clearancementioning

confidence: 99%

A review of existing strategies for designing long-acting parenteral formulations: Focus on underlying mechanisms, and future perspectives

Shi

Wang

et al. 2021

Acta Pharmaceutica Sinica B

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The need for long-term treatments of chronic diseases has motivated the widespread development of long-acting parenteral formulations (LAPFs) with the aim of improving drug pharmacokinetics and therapeutic efficacy. LAPFs have been proven to extend the half-life of therapeutics, as well as to improve patient adherence; consequently, this enhances the outcome of therapy positively. Over past decades, considerable progress has been made in designing effective LAPFs in both preclinical and clinical settings. Here we review the latest advances of LAPFs in preclinical and clinical stages, focusing on the strategies and underlying mechanisms for achieving long acting. Existing strategies are classified into manipulation of in vivo clearance and manipulation of drug release from delivery systems, respectively. And the current challenges and prospects of each strategy are discussed. In addition, we also briefly discuss the design principles of LAPFs and provide future perspectives of the rational design of more effective LAPFs for their further clinical translation.

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Section: Existing Strategies To Manipulate the Drug In Vivo Clearancementioning

confidence: 99%

A review of existing strategies for designing long-acting parenteral formulations: Focus on underlying mechanisms, and future perspectives

Shi

Wang

et al. 2021

Acta Pharmaceutica Sinica B

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“…Furthermore, the CD44 and CD11b contents in macrophage membranes, NLCs, and MM-NLCs were determined by Western blot analysis (Gao et al., 2020 ). First, the total protein was extracted by Protein Extraction Kits (GenePool/GPP1815) and used for measurements.…”

Section: Methodsmentioning

confidence: 99%

Cepharanthine loaded nanoparticles coated with macrophage membranes for lung inflammation therapy

Zheng²,

Ding

et al. 2021

Drug Delivery

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Acute lung injury (ALI) is a disease associated with suffering and high lethality, but to date without any effective pharmacological management in the clinic. In the pathological mechanisms of ALI, a strong inflammatory response plays an important role. Herein, based on macrophage ‘homing’ into inflammation sites and cell membrane coating nanotechnology, we developed a biomimetic anti-inflammation nanosystem (MM-CEP/NLCs) for the treatment of ALI. MM-CEP/NLCs were made with nanostructured lipid carriers (NLCs) coated with natural macrophage membranes (MMs) to achieve effective accumulation of cepharanthine (CEP) in lung inflammation to achieve the effect of treating ALI. With the advantage of suitable physicochemical properties of NLCs and unique biological functions of the macrophage membrane, MM-CEP/NLCs were stabilized and enabled sustained drug release, providing improved biocompatibility and long-term circulation. In vivo , the macrophage membranes enabled NLCs to be targeted and accumulated in the inflammation sites. Further, MM-CEP/NLCs significantly attenuated the severity of ALI, including lung water content, histopathology, bronchioalveolar lavage cellularity, protein concentration, and inflammation cytokines. Our results provide a bionic strategy via the biological properties of macrophages, which may have greater value and application prospects in the treatment of inflammation.

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“…With that in mind, some researchers now focus on the targeted delivery of antioxidants to the mitochondria of neurons. Gao et al [ 136 ] reported that the biomimetic nanosystem designed for their study effectively crossed the blood-brain barrier and delivered curcumin to the mitochondria of neurons. Based on the findings reported by Yang et al [ 135 ], the resveratrol-encapsulated neuronal mitochondria-targeted micelle designed for their study was able to facilitate the delivery of high levels of resveratrol into the brain mitochondria; this efficiently reduced oxidative stress, decreased A β plaque formation, and ameliorated tau hyperphosphorylation, neuroinflammation, and declined memory function in an aged AD mice model.…”

Section: Targeting Oxidative Stress In Alzheimer's Diseasementioning

confidence: 99%

Section: Targeting Oxidative Stress In Alzheimer's Diseasementioning

confidence: 99%

Redox Homeostasis and Prospects for Therapeutic Targeting in Neurodegenerative Disorders

Akanji

Rotimi

Elebiyo

et al. 2021

Oxidative Medicine and Cellular Longevity

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Reactive species, such as those of oxygen, nitrogen, and sulfur, are considered part of normal cellular metabolism and play significant roles that can impact several signaling processes in ways that lead to either cellular sustenance, protection, or damage. Cellular redox processes involve a balance in the production of reactive species (RS) and their removal because redox imbalance may facilitate oxidative damage. Physiologically, redox homeostasis is essential for the maintenance of many cellular processes. RS may serve as signaling molecules or cause oxidative cellular damage depending on the delicate equilibrium between RS production and their efficient removal through the use of enzymatic or nonenzymatic cellular mechanisms. Moreover, accumulating evidence suggests that redox imbalance plays a significant role in the progression of several neurodegenerative diseases. For example, studies have shown that redox imbalance in the brain mediates neurodegeneration and alters normal cytoprotective responses to stress. Therefore, this review describes redox homeostasis in neurodegenerative diseases with a focus on Alzheimer’s and Parkinson’s disease. A clearer understanding of the redox-regulated processes in neurodegenerative disorders may afford opportunities for newer therapeutic strategies.

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Neuronal mitochondria-targeted delivery of curcumin by biomimetic engineered nanosystems in Alzheimer's disease mice

Cited by 92 publications

References 50 publications

A review of existing strategies for designing long-acting parenteral formulations: Focus on underlying mechanisms, and future perspectives

A review of existing strategies for designing long-acting parenteral formulations: Focus on underlying mechanisms, and future perspectives

Cepharanthine loaded nanoparticles coated with macrophage membranes for lung inflammation therapy

Redox Homeostasis and Prospects for Therapeutic Targeting in Neurodegenerative Disorders

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