Neuronal LRP4 directs the development, maturation, and cytoskeletal organization of peripheral synapses
Alison T. DePew,
Joseph J. Bruckner,
Kate M. O’Connor-Giles
et al.
Abstract:Synapse development requires multiple signaling pathways to accomplish the myriad of steps needed to ensure a successful connection. Transmembrane receptors on the cell surface are optimally positioned to facilitate communication between the synapse and the rest of the neuron and often function as synaptic organizers to synchronize downstream signaling events. One such organizer, the LDL receptor-related protein LRP4, is a cell surface receptor most well-studied postsynaptically at mammalian neuromuscular junc… Show more
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