Neuronal injury in the motor cortex after chronic stroke and lower limb motor impairment: a voxel-based lesion symptom mapping study

Abstract

Many studies have examined motor impairments using voxel-based lesion symptom mapping, but few are reported regarding the corresponding relationship between cerebral cortex injury and lower limb motor impairment analyzed using this technique. This study correlated neuronal injury in the cerebral cortex of 16 patients with chronic stroke based on a voxel-based lesion symptom mapping analysis. Neuronal injury in the corona radiata, caudate nucleus and putamen of patients with chronic stroke could predict walking speed. The behavioral measure scores were consistent with motor deficits expected after damage to the cortical motor system due to stroke. These findings suggest that voxel-based lesion symptom mapping may provide a more accurate prognosis of motor recovery from chronic stroke according to neuronal injury in cerebral motor cortex.

Cortical disconnection of the ipsilesional primary motor cortex is associated with gait speed and upper extremity motor impairment in chronic left hemispheric stroke

“…Previous research has demonstrated increased putamen activation during imagined standing and walking in healthy adults [Jahn et al, ]. Moreover, damage to the putamen has been associated with temporal gait asymmetry [Alexander et al, ] and decreased walking speed [Reynolds et al, ] in individuals with chronic stroke, highlighting basal ganglia involvement in modulation of gait.…”

Acute Ischemic Stroke Infarct Topology: Association with Lesion Volume and Severity of Symptoms at Admission and Discharge

“…To achieve optimal statistical power, we included only voxels affected in at least 10 patients in the voxel-based analysis (On-line Fig 1B), as suggested by prior studies. 17 For each series of analyses, the family-wise error Bonferroni-corrected z scores corresponding to .05 and .01 P value thresholds are listed with the depiction window narrowed to approximate corresponding levels (…”

Boundary and vulnerability estimation of the internal borderzone using ischemic stroke lesion mapping

“…In a multivariate analysis, an infarction of more 50% of the insular ribbon predicts poor outcome independently of DWI lesion volume and NIHSS 26 (National Institutes of Health Stroke Score). Voxel-based lesion symptom mapping approaches not only linked the insula 8,23,27 to negative functional outcome but also the corona radiata 8 and the caudate nucleus 27 . The IBZ constitutes the vascular field irrigating these regions and they are encompassed in our IBZ estimate.…”