Neuronal Induction of Bone‐Fat Imbalance through Osteocyte Neuropeptide Y (Adv. Sci. 24/2021)

Zhang, Yan; Chen, Chun‐Yuan; Liu, Yiwei; Rao, Shan‐Shan; Tan, Yuyong; Qian, Yuxuan; Xia, Kun; Huang, Jie; Liu, Xi‐Xi; Hong, Chengyu; Yin, Hao; Cao, Jia; Feng, Shi‐Kai; He, Zehui; Li, Youyou; Luo, Zhenguo; Wu, Ben; Yan, Ziqi; Chen, Tuan‐Hui; Chen, Menglu; Wang, Yiyi; Wang, Zhenxing; Liu, Zhengzhao; Hu, Xiaozhou; Jin, Ling; Wan, Tengfei; Tao, Yue; Tang, Siyuan; Xie, Hui

doi:10.1002/advs.202170165

Cited by 2 publications

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“…Neuropeptide Y (NPY) is a highly conserved neuropeptide that is important for various physiological processes expressed in both nerve system and bone tissue, it acts by binding to its receptors Y1, Y2, Y4, Y5, and Y6, Y1 and Y2 are mainly expressed in osteoblasts, osteocytes and bones tissues ( 109 ). They play a major role in osteoblast lineage differentiation ( 110 ) as well as bone homeostasis, during aging it is secreted by osteocytes, they differentiate BMSCs into adipogenic cells, NPY deletion form osteocytes results in an increase in the bone mass ( 111 ).…”

Section: Growth Factors For Nerve Regenerationmentioning

confidence: 99%

Bone-nerve crosstalk: a new state for neuralizing bone tissue engineering—A mini review

Damiati,

El Soury

2024

Front. Med.

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Neuro bone tissue engineering is a multidisciplinary field that combines both principles of neurobiology and bone tissue engineering to develop innovative strategies for repairing and regenerating injured bone tissues. Despite the fact that regeneration and development are considered two distinct biological processes, yet regeneration can be considered the reactivation of development in later life stages to restore missing tissues. It is noteworthy that the regeneration capabilities are distinct and vary from one organism to another (teleost fishes, hydra, humans), or even in the same organism can vary dependent on the injured tissue itself (Human central nervous system vs. peripheral nervous system). The skeletal tissue is highly innervated, peripheral nervous system plays a role in conveying the signals and connecting the central nervous system with the peripheral organs, moreover it has been shown that they play an important role in tissue regeneration. Their regeneration role is conveyed by the different cells' resident in it and in its endoneurium (fibroblasts, microphages, vasculature associated cells, and Schwann cells) these cells secrete various growth factors (NGF, BDNF, GDNF, NT-3, and bFGF) that contribute to the regenerative phenotype. The peripheral nervous system and central nervous system synchronize together in regulating bone homeostasis and regeneration through neurogenic factors and neural circuits. Receptors of important central nervous system peptides such as Serotonin, Leptin, Semaphorins, and BDNF are expressed in bone tissue playing a role in bone homeostasis, metabolism and regeneration. This review will highlight the crosstalk between peripheral nerves and bone in the developmental stages as well as in regeneration and different neuro-bone tissue engineering strategies for repairing severe bone injuries.

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Section: Growth Factors For Nerve Regenerationmentioning

confidence: 99%

Bone-nerve crosstalk: a new state for neuralizing bone tissue engineering—A mini review

Damiati,

El Soury

2024

Front. Med.

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“…The central nervous system plays a role in the regulation of bone formation and bone remodeling [ 16 ]. The central nervous system influences bone physiology through the peripheral nervous system, pituitary-derived hormones, and other brain-derived molecules [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

The Dopamine D1 Receptor Attenuates Titanium Particle-Induced Inhibition of Osteogenesis by Activating the Wnt Signaling Pathway

Feng

et al. 2023

Mediators of Inflammation

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Periprosthetic osteolysis (PPO), caused by wear particles, has become a major cause of joint replacement failure. Secondary surgery after joint replacement poses a serious threat to public health worldwide. Therefore, determining how to effectively inhibit wear particle-induced PPO has become an urgent issue. Recently, the interaction between osteogenic inhibition and wear particles at the biological interface of the implant has been found to be an important factor in the pathological process. Previous studies have found that the central nervous system plays an important role in the regulation of bone formation and bone remodeling. Dopamine (DA), an important catecholamine neurotransmitter, plays an integral role in the physiological and pathological processes of various tissues through its corresponding receptors. Our current study found that upregulation of dopamine first receptors could be achieved by activating the Wnt/β-catenin pathway, improving osteogenesis in vivo and in vitro, and significantly reducing the inhibition of titanium particle-induced osteogenesis. Overall, these findings suggest that dopamine first receptor (D1R) may be a plausible target to promote osteoblast function and resist wear particle-induced PPO.

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Neuronal Induction of Bone‐Fat Imbalance through Osteocyte Neuropeptide Y (Adv. Sci. 24/2021)

Cited by 2 publications

References 0 publications

Bone-nerve crosstalk: a new state for neuralizing bone tissue engineering—A mini review

Bone-nerve crosstalk: a new state for neuralizing bone tissue engineering—A mini review

The Dopamine D1 Receptor Attenuates Titanium Particle-Induced Inhibition of Osteogenesis by Activating the Wnt Signaling Pathway

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