Neuronal globus pallidus activity in patients with generalised dystonia

Merello, Marcelo; Cerquetti, Daniel; Cammarota, Angel; Tenca, Eduardo; Artes, Carlos; Antico, Julio; Leiguarda, R

doi:10.1002/mds.10700

Cited by 48 publications

(26 citation statements)

References 21 publications

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“…Bursting may be oscillatory or nonoscillatory. GPi bursting in human dystonia has been reported previously (Hutchison et al 2003;Merello et al 2004;Vitek et al 1999). However, descriptions of discharge pattern are difficult to interpret in the absence of comparison data from nondystonic subjects, and only one study (Hutchison et al 2003) provided a quantitative statistical measure of bursting.…”

Section: Oscillations and Bursts In Pallidal Discharge Are Prominent mentioning

confidence: 72%

“…A handful of studies have been published on pallidal neuronal physiology in awake humans with dystonia (23 cases total) (Hutchison et al 2003;Lenz et al 1998;Merello et al 2004;Sanghera et al 2003;Vitek et al 1999). These series focused primarily on spontaneous discharge rates.…”

Section: Comparision With Prior Studies Of Gpi Discharge Rate In Dystmentioning

confidence: 99%

“…Four reports, describing data collected from a total of 16 patients reported that the mean spontaneous GPi discharge rate is abnormally low in dystonia (Lenz et al 1998;Merello et al 2004;Sanghera et al 2003;Vitek et al 1999). In contrast, Hutchison et al (2003) showed that in seven dystonic patients, GPi discharge was not reduced and was in fact similar to the hyperactive pallidal discharge of Parkinson's disease.…”

Section: Introductionmentioning

confidence: 99%

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Spontaneous Pallidal Neuronal Activity in Human Dystonia: Comparison With Parkinson’s Disease and Normal Macaque

Starr¹,

Rau²,

Davis³

et al. 2005

Journal of Neurophysiology

246

183

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. Dystonia is a movement disorder defined by sustained muscle contractions, causing twisting and repetitive movements and abnormal postures. To understand the abnormalities in pallidal discharge in dystonia, we have analyzed the spontaneous activity of 453 neurons sampled from the internal or external pallidum (GPi or GPe) of 22 patients with dystonia, 140 neurons from 11 patients with Parkinson's disease (PD), and 157 neurons from two normal non-human primates (NHPs; Macacca mulatta). All recordings were performed without systemic sedation. Mean GPi discharge rate in dystonia was 55.3 Ϯ 1.3 (SE) Hz. This was significantly lower than in the normal NHPs (82.5 Ϯ2.5 Hz) and lower than in PD patients (95.2 Ϯ 2.3 Hz). Mean GPe discharge rate in dystonia (54.0 Ϯ 1.9 Hz) was lower than in the normal NHPs (69.7 Ϯ 3.3 Hz) and was indistinguishable from that in PD patients (56.6 Ϯ 3.5 Hz). Mean GPi discharge rate was inversely correlated with dystonia severity. GPi showed increased oscillatory activity in the 2-to 10-Hz range and increased bursting activity in both dystonia and PD as compared with the normal NHPs. Because the abnormalities in discharge patterns were similar in dystonia compared with PD, we suggest that bursting and oscillatory activity superimposed on a high background discharge rate are associated with parkinsonism, whereas similar bursting and oscillations superimposed on a lower discharge rate are associated with dystonia. Our findings are most consistent with a model of dystonia pathophysiology in which the two striatal cell populations contributing to the direct and indirect intrinsic pathways of the basal ganglia both have increased spontaneous activity.

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Section: Oscillations and Bursts In Pallidal Discharge Are Prominent mentioning

confidence: 72%

Section: Comparision With Prior Studies Of Gpi Discharge Rate In Dystmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Spontaneous Pallidal Neuronal Activity in Human Dystonia: Comparison With Parkinson’s Disease and Normal Macaque

Starr¹,

Rau²,

Davis³

et al. 2005

Journal of Neurophysiology

246

183

View full text Add to dashboard Cite

show abstract

“…A trend for low firing rate with a bursty pattern and oscillations was reported in the internal pallidum (112)(113)(114)(115)(116) and subthalamic nucleus (117). However, the role of anaesthesia was debated because some authors found no difference between dystonic and PD patients (118,119). The current pathophysiological model of dystonia was also questioned by data showing that pallidal DBS was able to inihibit a subpopulation of motor thalamic neurons (120) and the abscence of difference between GPe and GPi firing rate (119).…”

Section: Or Cerebellum (93)mentioning

confidence: 99%

“…However, the role of anaesthesia was debated because some authors found no difference between dystonic and PD patients (118,119). The current pathophysiological model of dystonia was also questioned by data showing that pallidal DBS was able to inihibit a subpopulation of motor thalamic neurons (120) and the abscence of difference between GPe and GPi firing rate (119). However, clear correlation between abnormal neuronal activitiy and EMG activity was reported in the basal ganglia and thalamus of patients with dystonia (116,(121)(122)(123).…”

Section: Or Cerebellum (93)mentioning

confidence: 99%

Dystonia Pathophysiology: A Critical Review

Burbaud¹

2012

Dystonia - The Many Facets

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Acute Deep-Brain Stimulation of the Internal and External Globus Pallidus in Primary Dystonia

Houeto

Yelnik²,

Bardinet³

et al. 2007

Arch Neurol

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Background: Dystonia is a syndrome characterized by prolonged muscle contractions that cause sustained twisting movements and abnormal posturing of body parts. Patients with the severe and generalized forms can benefit from bilateral high-frequency pallidal stimulation. Objective: To investigate the functional map of the globus pallidus (GP) in patients with primary generalized dystonia. Design: Prospective multicenter, double-blind, videocontrolled study in patients treated at a university hospital. Setting: University secondary care centers. Patients: Twenty-two patients with primary generalized dystonia. Interventions: Acute internal and external pallidal deepbrain stimulation or pallidal deep-brain stimulation. Main Outcome Measures: The clinical effects of acute bilateral high-frequency ventral vs acute dorsal pallidal stimulation were assessed with the Movement subscale of the Burke-Fahn-Marsden Dystonia Rating Scale. In-trapallidal localization of the contacts of the quadripolar electrodes was performed using a 3-dimensional atlas-magnetic resonance imaging coregistration method by investigators blinded to the clinical outcome. Results: Bilateral acute ventral stimulation of the GP significantly improved the Burke-Fahn-Marsden Dystonia Rating Scale score by 42% and resulted in stimulation of contacts located in the internal GP or medullary lamina in 18 of 21 patients. Bilateral acute dorsal pallidal stimulation, primarily localized within the external GP, had variable effects across patients, with half demonstrating slight or no improvement or even aggravation of dystonia compared with baseline. Conclusions: Ventral pallidal stimulation, primarily of the internal GP or medullary lamina or both, is the optimal method for the treatment of dystonia. The varying effects across patients of bilateral acute dorsal pallidal stimulation, primarily of the external GP, suggest that unknown factors associated with dystonia could have a role in and contribute to the effects of the electrical stimulation.

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Neuronal globus pallidus activity in patients with generalised dystonia

Cited by 48 publications

References 21 publications

Spontaneous Pallidal Neuronal Activity in Human Dystonia: Comparison With Parkinson’s Disease and Normal Macaque

Spontaneous Pallidal Neuronal Activity in Human Dystonia: Comparison With Parkinson’s Disease and Normal Macaque

Dystonia Pathophysiology: A Critical Review

Acute Deep-Brain Stimulation of the Internal and External Globus Pallidus in Primary Dystonia

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