Neuronal death by repetitive cortical spreading depression in juvenile rat brain

Sadeghian, Homa; Jafarian, M.; Karimzadeh, Fariba; Kafami, Laya; Kazemi, Hadi; Coulon, Philippe; Ghabaee, Mojdeh; Gorji, Ali

doi:10.1016/j.expneurol.2011.11.017

Cited by 40 publications

(25 citation statements)

References 51 publications

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“…NRP2945 reduced the mean number of dark neurons after PTZ-induced convulsion. Dark cells, as a measure of degenerating neurons, have been shown in mechanical neuronal trauma, ischemia, hypoglycaemia, exposure to excitatory amino acids, and after induction of spreading depression in addition to epilepsy (Ishida et al, 2004;Sadeghian et al, 2012). PTZ-induced seizure was correlated with increased mean number of dark neurons in the hippocampus and neocortex (Karimzadeh et al, 2012).…”

Section: Discussionmentioning

confidence: 95%

“…Dark neurons were identified by neuronal shrinkage, cytoplasmic eosinophillia, nuclear pyknosis, and surrounding spongiosis (Jafarian et al, 2010;Sadeghian et al, 2012). The mean number of dark neurons was significantly higher in all evaluated area in PTZ group compared to control rats (P≤0.001; Fig.…”

Section: The Effect Of Nrp2945 On Production Of Dark Neuronsmentioning

confidence: 88%

“…On each pair of sections, at least 10 microscopic fields were selected by uniform systematic-random sampling in every area of interest. Using the unbiased frame and physical dissector counting rule, the counting of dark neurons in each field was carried out (Jafarian et al, 2010;Sadeghian et al, 2012).…”

Section: Stereological Methods and Physical Dissectormentioning

confidence: 99%

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Anticonvulsant effect of neural regeneration peptide 2945 on pentylenetetrazol-induced seizures in rats

et al. 2015

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Section: Discussionmentioning

confidence: 95%

Section: The Effect Of Nrp2945 On Production Of Dark Neuronsmentioning

confidence: 88%

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Anticonvulsant effect of neural regeneration peptide 2945 on pentylenetetrazol-induced seizures in rats

et al. 2015

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“…Chi-square analysis was used for comparison of categorical variables, and independent sample t-test and one-way ANOVA for quantitative variables (14,24). Logistic regression was used to analyse the effects of variables on bimodal outcome variables (16,26,30,31 20 females, M/F ratio = 1.4) who were admitted to the Shohada Tajrish Hospital with the diagnosis of pineal region tumor and fulfilled the inclusion and exclusion criteria were enrolled in the study.…”

Section: Methodsmentioning

confidence: 99%

Treatment results for pineal region tumors: role of stereotactic biopsy plus adjuvant therapy vs. open resection

Motiei-Langroudi¹,

Sadeghian²,

Soleimani³

et al. 2014

Turkish Neurosurgery

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Because optimal therapeutic strategies vary with tumor type, a histologic diagnosis by either stereotactic or endoscopic biopsy or open surgery is the foundation of management decisions. Stereotactic biopsy has the advantage of ease and minimal invasiveness but is associated with more sampling errors than open surgery (19), while open resection facilitates maximal removal of tumor volume with more diagnostic accuracy. However, all surgical procedures in the pineal region, including both stereotactic biopsy and open surgery, are potentially hazardous (3,11). █ INTRODUCTIONPineal region tumors represent 0.4-1.0% of intracranial tumors and can harbor highly diverse histologic tumor subtypes, including germ cell, pineal parenchymal, and glial tumors (21).The tumor manifestations are the consequence of their pressure effects and consist of visual disturbances, headache, mental deterioration, Parinaud's syndrome, non-communicating hydrocephalus, and sometimes dementia-like behavior. MATERIAL and METHODS:We present the results of 48 patients with pineal tumor treated either by stereotactic biopsy followed by adjuvant therapy (23 patients) or open surgical resection without (18 patients) or with (7 patients) adjuvant therapy in Shohada Tajrish Hospital, Iran (1993.RESULTS: unremarkable pathology yield was 3/23 in the biopsy and 1/25 in the surgical group. Perioperative mortality and morbidity were 4.3% and 0% in the biopsy group and 32.0% and 4.0% in the surgical group. Analysis showed that age, gender, cranial nerve deficit, motor deficit, preoperative Karnofsky Performance Score (KPS), midbrain involvement, and brain stem involvement had no effect on neither perioperative mortality nor long-term survival, while local invasion and pineocytoma pathology increased perioperative mortality and presence of hydrocephalus and pineoblastoma pathology significantly decreased long-term survival. Hospitalization length was shorter in the stereotactic biopsy plus adjuvant therapy group. CONCLUSION:The results of the study suggests that although gross total resection is the standard of care in most pineal tumors nowadays, stereotactic biopsy followed by adjuvant therapy may still be a safe and viable option.

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“…Quantification of results was performed by densitometric scan of films, and data analysis was done by ImageJ, measuring integrated density of bands after background subtraction. Nuclear and cytoplasmic proteins were isolated as described earlier [19].…”

Section: Western Blot Analysismentioning

confidence: 99%

Protective Effect of a cAMP Analogue on Behavioral Deficits and Neuropathological Changes in Cuprizone Model of Demyelination

et al. 2014

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Multiple sclerosis (MS) is an inflammatory demyelinating disease that leads to neuronal cell loss. Cyclic AMP and its analogs are well known to decrease inflammation and apoptosis. In the present study, we examined the effects of bucladesine, a cell-permeable analogue of cyclic adenosine monophosphate (cAMP), on myelin proteins (PLP, PMP-22), inflammation, and apoptotic, as well as anti-apoptotic factors in cuprizone model of demyelination. C57BL/6J mice were fed with chow containing 0.2% copper chelator cuprizone or vehicle by daily oral gavage for 5 weeks to induce reversible demyelination predominantly of the corpus callosum. Bucladesine was administered intraperitoneally at different doses (0.24, 0.48, or 0.7 μg/kg body weight) during the last 7 days of 5-week cuprizone treatment. Bucladesine exhibited a protective effect on myelination. Furthermore, bucladesine significantly decreased the production of interleukin-6 pro-inflammatory mediator as well as nuclear factor-κB activation and reduced the mean number of apoptotic cells compared to cuprizone-treated mice. Bucladesine also decreased production of caspase-3 as well as Bax and increased Bcl-2 levels. Our data revealed that enhancement of intracellular cAMP prevents demyelination and plays anti-inflammatory and anti-apoptotic properties in mice cuprizone model of demyelination. This suggests the modulation of intracellular cAMP as a potential target for treatment of MS.

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Neuronal death by repetitive cortical spreading depression in juvenile rat brain

Cited by 40 publications

References 51 publications

Anticonvulsant effect of neural regeneration peptide 2945 on pentylenetetrazol-induced seizures in rats

Anticonvulsant effect of neural regeneration peptide 2945 on pentylenetetrazol-induced seizures in rats

Treatment results for pineal region tumors: role of stereotactic biopsy plus adjuvant therapy vs. open resection

Protective Effect of a cAMP Analogue on Behavioral Deficits and Neuropathological Changes in Cuprizone Model of Demyelination

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