Neuronal ciliary signaling in homeostasis and disease

Green, Jill A.; Mykytyn, Kirk

doi:10.1007/s00018-010-0425-4

Cited by 65 publications

(58 citation statements)

References 106 publications

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“…Recent evidence suggests important roles for the primary cilium in mediating a host of extracellular signaling events such as morphogen, mitogen, homeostatic and polarity signals. Based upon the clinical features of ciliopathies and cilia mediated signaling pathways, the data support a role for the primary cilium in modulating neurogenesis, cell polarity, axonal guidance and possibly adult neuronal function [97,98]. …”

Section: Cognitive Impairmentmentioning

confidence: 76%

Ciliopathies: Primary Cilia and Signaling Pathways in Mammalian Development

Romero¹,

Solano²,

Cabo³

2011

Neuroimaging for Clinicians - Combining Research and Practice

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Section: Cognitive Impairmentmentioning

confidence: 76%

Ciliopathies: Primary Cilia and Signaling Pathways in Mammalian Development

Romero¹,

Solano²,

Cabo³

2011

Neuroimaging for Clinicians - Combining Research and Practice

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“…Worth noting the presence of primary cilia which are immotile and slender microtubule-based organelles (9+0) that usually exist in a single copy on the surface of different cell types including chondrocytes [21]. They are sensory cellular antennae that can co-ordinate different cellular signalling pathways [22] functioning as a unique cellular site for mechano-and chemo-sensation to regulate cellular processes during development and in tissue homeostasis [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Primary Cilia in Chondrogenic Differentiation of Equine Bone Marrow Mesenchymal Stem Cells: Ultrastructural Study

Luesma

Cantarero

Ranera

et al. 2016

Journal of Equine Veterinary Science

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Locomotor system disorders in equine species, such as tendon lesions, osteoarthritis or ligament injuries, are some of the most frequent causes of dramatic reduction in horse performance. Traditional therapies are aimed at the inflammatory process and pain, but they do not regenerate normal tendon or ligament matrix and do not reduce re-injured rates. Mesenchymal stem cells have started to use as therapeutic option to repair these injured tissues. Most studies have focused on their isolation, in vitro culture and phenotyping. However, mesenchymal stem cell ultrastructure has been disregarded in the last years. We investigate the ultrastructural characteristics of these cells once differentiated into chondrocytes. Ultrastructural analysis was conducted on suspension cultures of differentiated chondrocytes from bone marrow mesenchymal stem cells by means of transmission electron microscopy. The morphological characteristics of these cells, their ability to produce the extracellular matrix and the presence of a single cilium, could be indicative of the mesenchymal cells differentiation into chondrocyte phenotype. This study provides essential data to evaluate the degree of suitable phenotypic stability, for these cells can be used with repair purposes.

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“…In particular, some ciliopathy patients display a range of neurological disorders including cognitive deficits (Lee and Gleeson, 2011), thereby highlighting the importance of primary cilia function within the brain (Green and Mykytyn, 2010). Let us briefly describe some main structural features of these crucial appendages and then some of their possible functional implications, while for a more detailed description, the reader is referred to several excellent reviews that have been recently published (Louvi and Grove, 2011;Guemez-Gamboa et al, 2014;Malicki and Avidor-Reiss, 2014).…”

Section: Introductionmentioning

confidence: 99%

The multi-facet aspects of cell sentience and their relevance for the integrative brain actions: role of membrane protein energy landscape

Agnati¹,

Marcoli

Maura

et al. 2016

Reviews in the Neurosciences

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AbstractSeveral ion channels can be randomly and spontaneously in an open state, allowing the exchange of ion fluxes between extracellular and intracellular environments. We propose that the random changes in the state of ion channels could be also due to proteins exploring their energy landscapes. Indeed, proteins can modify their steric conformation under the effects of the physicochemical parameters of the environments with which they are in contact, namely, the extracellular, intramembrane and intracellular environments. In particular, it is proposed that the random walk of proteins in their energy landscape is towards attractors that can favor the open or close condition of the ion channels and/or intrinsic activity of G-protein-coupled receptors. The main aspect of the present proposal is that some relevant physicochemical parameters of the environments (e.g. molecular composition, temperature, electrical fields) with which some signaling-involved plasma membrane proteins are in contact alter their conformations. In turn, these changes can modify their information handling via a modulatory action on their random walk towards suitable attractors of their energy landscape. Thus, spontaneous and/or signal-triggered electrical activities of neurons occur that can have emergent properties capable of influencing the integrative actions of brain networks. Against this background, Cook’s hypothesis on ‘cell sentience’ is developed by proposing that physicochemical parameters of the environments with which the plasma-membrane proteins of complex cellular networks are in contact fulfill a fundamental role in their spontaneous and/or signal-triggered activity. Furthermore, it is proposed that a specialized organelle, the primary cilium, which is present in most cells (also neurons and astrocytes), could be of peculiar importance to pick up chemical signals such as ions and transmitters and to detect physical signals such as pressure waves, thermal gradients, and local field potentials.

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Neuronal ciliary signaling in homeostasis and disease

Cited by 65 publications

References 106 publications

Ciliopathies: Primary Cilia and Signaling Pathways in Mammalian Development

Ciliopathies: Primary Cilia and Signaling Pathways in Mammalian Development

Primary Cilia in Chondrogenic Differentiation of Equine Bone Marrow Mesenchymal Stem Cells: Ultrastructural Study

The multi-facet aspects of cell sentience and their relevance for the integrative brain actions: role of membrane protein energy landscape

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