Neuronal cell adhesion genes

Corvin, Aiden

doi:10.4161/cam.4.4.12460

Cited by 29 publications

(9 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The GO annotation showed that neuroticism-related genes were mainly involved in biological adhesion and cell adhesion, which has been found to be associated with neuroticism in previous studies (Kim et al, 2015;Luciano et al, 2017). In our research, both biological adhesion and cell adhesion contained some different neural cell adhesion molecules (NCAM) and other cell adhesion molecules, which played a key role in brain development and cell transfer (Corvin, 2010;Sytnyk et al, 2017). A previous study showed that the dysregulation of NCAM was related to the abnormality of mouse cingulate cortex (like human prefrontal cortex) (Brennaman & Maness, 2008).…”

Section: Discussionsupporting

confidence: 62%

Rostral middle frontal gyrus thickness mediates the relationship between genetic risk and neuroticism trait

et al. 2020

View full text Add to dashboard Cite

Neuroticism is a robust personality trait associated with multiple mental disorders. Heretofore, research on the relationship among genes, brain, and behavior to explore individual differences in neuroticism is scarce. Hence, in this study (N = 630), genetic data, self‐reported neuroticism, and brain structural data were combined to explore whether the cortical thickness (CT) of brain regions mediated the relationship between the polygenic risk score (PRS) of neuroticism and NEO neuroticism (NEO‐N), and the enrichment analysis was performed to reveal the underlying mechanism of their relationship. Results showed that the PRSs were significantly associated with NEO‐N scores (p < .05). The CT of left rostral middle frontal gyrus was negatively related to the best PRS in PRSice (PRSbest) or the PRS at 0.05 threshold (PRS0.05) (corrected p < .05), which was also found to mediate the association between the PRS and NEO‐N (PRSbest: ab = .012, p < .05; PRS0.05: ab = .012, p < .05). Enrichment analysis revealed that these genes were mainly involved in biological adhesion, cell adhesion, neuron part, and synapse part, which were associated with the abnormal thickness of frontal cortex. By integrating genetic, brain imaging, and behavioral data, our research initially revealed the neurogenetic underpinnings of neuroticism, which is helpful for understanding individual differences in neuroticism.

show abstract

Section: Discussionsupporting

confidence: 62%

Rostral middle frontal gyrus thickness mediates the relationship between genetic risk and neuroticism trait

et al. 2020

View full text Add to dashboard Cite

show abstract

“…They include APP processing, cholesterol and lipoprotein function, complement and immune related genes, and oxidative stress, apoptosis and ubiquitin genes in Alzheimer's disease [96–100]. In bipolar disorder, monoamine/GABA, signalling, adhesion, and ion transport genes are highlighted (see above and [101–103]) while in schizophrenia, monoamine/glutamate/neuregulin neuronal development and associated signalling related genes figure prominently, along with those related to adhesion, oxidative stress, and immune activation (see above). In multiple sclerosis, almost the entire common dataset is related to immune function and associated signalling pathways, that are relevant to the autoimmune aspects of the disease [104, 105], with a limited number of genes related to oxidative stress and apoptosis.…”

Section: Resultsmentioning

confidence: 99%

Toxoplasmosis and Polygenic Disease Susceptibility Genes: ExtensiveToxoplasma gondiiHost/Pathogen Interactome Enrichment in Nine Psychiatric or Neurological Disorders

Carter

2013

Journal of Pathogens

View full text Add to dashboard Cite

Toxoplasma gondii is not only implicated in schizophrenia and related disorders, but also in Alzheimer's or Parkinson's disease, cancer, cardiac myopathies, and autoimmune disorders. During its life cycle, the pathogen interacts with ~3000 host genes or proteins. Susceptibility genes for multiple sclerosis, Alzheimer's disease, schizophrenia, bipolar disorder, depression, childhood obesity, Parkinson's disease, attention deficit hyperactivity disorder (P from 8.01E − 05 (ADHD) to 1.22E − 71) (multiple sclerosis), and autism (P = 0.013), but not anorexia or chronic fatigue are highly enriched in the human arm of this interactome and 18 (ADHD) to 33% (MS) of the susceptibility genes relate to it. The signalling pathways involved in the susceptibility gene/interactome overlaps are relatively specific and relevant to each disease suggesting a means whereby susceptibility genes could orient the attentions of a single pathogen towards disruption of the specific pathways that together contribute (positively or negatively) to the endophenotypes of different diseases. Conditional protein knockdown, orchestrated by T. gondii proteins or antibodies binding to those of the host (pathogen derived autoimmunity) and metabolite exchange, may contribute to this disruption. Susceptibility genes may thus be related to the causes and influencers of disease, rather than (and as well as) to the disease itself.

show abstract

“… 44 In addition, CAMs are associated with cognition 45 and various neuropsychiatric disorders. 46 Also, prior studies point to various CAM genes in addiction vulnerability. 47 Neuronal CAM gene, implicated in the CAM pathway ( Supplementary Table S1 ) is involved in neuron–neuron adhesion and promotes directional signaling during axonal cone growth.…”

Section: Discussionmentioning

confidence: 99%

Genetic association of impulsivity in young adults: a multivariate study

et al. 2014

View full text Add to dashboard Cite

Impulsivity is a heritable, multifaceted construct with clinically relevant links to multiple psychopathologies. We assessed impulsivity in young adult (N~2100) participants in a longitudinal study, using self-report questionnaires and computer-based behavioral tasks. Analysis was restricted to the subset (N=426) who underwent genotyping. Multivariate association between impulsivity measures and single-nucleotide polymorphism data was implemented using parallel independent component analysis (Para-ICA). Pathways associated with multiple genes in components that correlated significantly with impulsivity phenotypes were then identified using a pathway enrichment analysis. Para-ICA revealed two significantly correlated genotype–phenotype component pairs. One impulsivity component included the reward responsiveness subscale and behavioral inhibition scale of the Behavioral-Inhibition System/Behavioral-Activation System scale, and the second impulsivity component included the non-planning subscale of the Barratt Impulsiveness Scale and the Experiential Discounting Task. Pathway analysis identified processes related to neurogenesis, nervous system signal generation/amplification, neurotransmission and immune response. We identified various genes and gene regulatory pathways associated with empirically derived impulsivity components. Our study suggests that gene networks implicated previously in brain development, neurotransmission and immune response are related to impulsive tendencies and behaviors.

show abstract

Neuronal cell adhesion genes

Cited by 29 publications

References 29 publications

Rostral middle frontal gyrus thickness mediates the relationship between genetic risk and neuroticism trait

Rostral middle frontal gyrus thickness mediates the relationship between genetic risk and neuroticism trait

Toxoplasmosis and Polygenic Disease Susceptibility Genes: ExtensiveToxoplasma gondiiHost/Pathogen Interactome Enrichment in Nine Psychiatric or Neurological Disorders

Genetic association of impulsivity in young adults: a multivariate study

Contact Info

Product

Resources

About