Neuronal and synaptic morphological alterations in the hippocampus of cannabinoid receptor type 1 knockout mice

Abstract

The endocannabinoid system, which has been conserved evolutionarily from plants to vertebrates (Elphick & Egertová, 2005; Solymosi & Köfalvi, 2017), modulates synaptic transmission and consists of cannabinoid receptors type 1 (CB1R) and type 2 (CB2R), its endogenous ligands (anandamide and 2-arachidonoylglycerol) and enzymes involved in its metabolism (Lambert & Fowler, 2005). CB1R is widely expressed in the central nervous system in vertebrates, both in neurons and glial cells (Facchinetti, Del Giudice,