Neuronal and psychological underpinnings of pathological gambling

Singer, Bryan F.; Anselme, Patrick; Robinson, Mike J.F.; Vezina, Paul

doi:10.3389/fnbeh.2014.00230

Cited by 6 publications

(4 citation statements)

References 15 publications

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“…For example, Singer et al . [ 96 ] reviewed the studies relating to the neurobiological underpinnings of GD based on the idea that the recent re-classification of GD as a Behavioral Addiction in the DSM-5 suggested that “similar cognitive and motivational phenotypes may underlie both gambling and substance use disorders” [ 96 ] (p. 1). In particular they described a number of studies which lend support to the idea that exposure to reward unpredictability can cause aberrant responses in the dopamine systems, which in turn mediates incentive salience to reward-related cues.…”

Section: Literature Reviewmentioning

confidence: 99%

Neuroscience of Internet Pornography Addiction: A Review and Update

Love¹,

Laier

Brand

et al. 2015

Behavioral Sciences

188

131

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Many recognize that several behaviors potentially affecting the reward circuitry in human brains lead to a loss of control and other symptoms of addiction in at least some individuals. Regarding Internet addiction, neuroscientific research supports the assumption that underlying neural processes are similar to substance addiction. The American Psychiatric Association (APA) has recognized one such Internet related behavior, Internet gaming, as a potential addictive disorder warranting further study, in the 2013 revision of their Diagnostic and Statistical Manual. Other Internet related behaviors, e.g., Internet pornography use, were not covered. Within this review, we give a summary of the concepts proposed underlying addiction and give an overview about neuroscientific studies on Internet addiction and Internet gaming disorder. Moreover, we reviewed available neuroscientific literature on Internet pornography addiction and connect the results to the addiction model. The review leads to the conclusion that Internet pornography addiction fits into the addiction framework and shares similar basic mechanisms with substance addiction. Together with studies on Internet addiction and Internet Gaming Disorder we see strong evidence for considering addictive Internet behaviors as behavioral addiction. Future research needs to address whether or not there are specific differences between substance and behavioral addiction.

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Section: Literature Reviewmentioning

confidence: 99%

Neuroscience of Internet Pornography Addiction: A Review and Update

Love¹,

Laier

Brand

et al. 2015

Behavioral Sciences

188

131

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“…Impairments in risk/reward evaluations occurs in many psychiatric disorders. One of these is gambling disorder, also called pathological gambling, that has been reclassified as a behavioral addiction in the DSM-5 [1], [2], [3]. Gambling disorder combines reward reinforcement and addiction with cognitive processes like reward-guided decision making and other executive functions [4] in a fascinating and complex way, and is characterized by an overstated preference for high and uncertain rewards [5].…”

Section: Introductionmentioning

confidence: 99%

“…Mesolimbic dopamine neurons have been proposed to modulate the reinforcing effects of gambling, and these same neurons appear to act as neural substrates for the reinforcement produced by ethanol and other substances of abuse [6], [7]. It has previously been shown that reward unpredictability can recruit brain dopamine systems in a similar 3 way to chronic exposure to drugs of abuse, and several research models have proposed that alterations in dopamine signaling mediate the transition from recreational gambling to gambling disorder [3], [8]. Risky and unprofitable decision making has been shown to be modulated by dopaminergic neuronal activity [9], [10], [11], [12], [13].…”

Section: Introductionmentioning

confidence: 99%

Dopaminergic modulation of reward-guided decision making in alcohol-preferring AA rats

Oinio

Bäckström

Uhari-Väänänen

et al. 2017

Behavioural Brain Research

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R**esults from animal gambling models have highlighted the importance of dopaminergic neurotransmission in modulating decision making when large sucrose rewards are combined with uncertainty. The majority of these models use food restriction as a tool to motivate animals to accomplish operant behavioral tasks, in which sucrose is used as a reward. As enhanced motivation to obtain sucrose due to hunger may impact its reward-seeking effect, we wanted to examine the decision-making behavior of rats in a situation where rats were fed ad libitum. For this purpose, we chose alcohol-preferring AA (alko alcohol) rats, as these rats have been shown to have high preference for sweet agents. In the present study, AA rats were trained to self-administer sucrose pellet rewards in a two-lever choice task (one pellet vs. three pellets). Once rational choice behavior had been established, the probability of gaining three pellets was decreased over time (50%, 33%, 25% then 20%). The effect of d-amphetamine on decision making was studied at every probability level, as well as the effect of the dopamine D receptor agonist SKF-81297 and D agonist quinpirole at probability levels of 100% and 25%. d-Amphetamine increased unprofitable choices in a dose-dependent manner at the two lowest probability levels. Quinpirole increased the frequency of unprofitable decisions at the 25% probability level, and SKF-82197 did not affect choice behavior. These results mirror the findings of probabilistic discounting studies using food-restricted rats. Based on this, the use of AA rats provides a new approach for studies on reward-guided decision making.

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“…Shared biomedical and psychosocial underpinnings of substance use disorder and PG/HG suggest that they may be treated with similar forms of therapy [33,47]. Despite this, CM, one of the most successful treatments for substance use disorders (upwards of 61% drug-free success rates for CM vs. 39% for control groups), has not been established as a possible therapy for PG/HG [30,48,49].…”

Section: For Gamblingmentioning

confidence: 99%

Voluntary Self-Exclusion and Contingency Management for the Treatment of Problematic and Harmful Gambling in the UK: An Exploratory Study

Zolkwer,

Dymond,

Singer

2023

Healthcare

Self Cite

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Research into self-directed methods for reducing problematic and harmful gambling is still in its infancy. One strategy that individuals use to prevent gambling involves voluntary self-exclusion (VSE) programs. For example, VSE programs can make it challenging to access betting sites or enable banks to block gambling-related transactions. Although individual VSEs can be helpful when used alone, it is unclear whether their efficacy is enhanced when combined. Furthermore, it is unknown how VSE compliance can be improved. We propose that contingency management (CM), an evidence-based strategy to incentivise abstinence, could encourage continued VSE use, promoting long-lasting recovery from problematic or harmful gambling. Here, we conducted exploratory analyses on VSE use and CM for gambling in two populations (members of the UK general population recruited and students). Participants responded favourably regarding combined VSE use. They felt that providing vouchers exchangeable for goods/services could incentivise gambling abstinence during VSE. However, some were concerned about people potentially “gaming” the system. Participants believed supplementing VSE and CM with social support could encourage abstinence. These attitudes, and recent research on treatment providers’ opinions on CM for gambling, suggest that experimental evidence should be sought to determine the efficacy of combined VSE use and CM for gambling.

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Neuronal and psychological underpinnings of pathological gambling

Cited by 6 publications

References 15 publications

Neuroscience of Internet Pornography Addiction: A Review and Update

Neuroscience of Internet Pornography Addiction: A Review and Update

Dopaminergic modulation of reward-guided decision making in alcohol-preferring AA rats

Voluntary Self-Exclusion and Contingency Management for the Treatment of Problematic and Harmful Gambling in the UK: An Exploratory Study

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