Neuronal activity patterns in the ventral thalamus: Comparison between Parkinson’s disease and cervical dystonia

Devetiarov, D.; Semenova, Ulia; Usova, Svetlana; Tomskiy, Alexey; Tyurnikov, V. M.; Nizametdinova, D. M.; Гуща, А. О.; Belova, Elena; Sedov, Alexey

doi:10.1016/j.clinph.2017.09.110

Cited by 5 publications

(4 citation statements)

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“…It has been reported that four patients with iCD received markedly improved dystonic head tremor and dystonia after continuous bilateral thalamic ventral lateral anterior nucleus stimulation for 3 months [37]. Previous studies have identi ed speci c patterns of neuronal activity and pathological features of the ventral thalamus in iCD [38,39]. Ventral thalamic neurons exhibiting dystonia-frequency activity in patients with iCD and suppression of this activity induced immediate improvement and subsequent further enhancement of dystonic movement and posture, revealing the critical role of the ventral thalamus as a key node within the network associated with dystonia [38,39].…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have identi ed speci c patterns of neuronal activity and pathological features of the ventral thalamus in iCD [38,39]. Ventral thalamic neurons exhibiting dystonia-frequency activity in patients with iCD and suppression of this activity induced immediate improvement and subsequent further enhancement of dystonic movement and posture, revealing the critical role of the ventral thalamus as a key node within the network associated with dystonia [38,39]. In our study, we observed that patients with iCD exhibited atrophy in the thalamus's VM, VLp, and VPL nuclei.…”

Section: Discussionmentioning

confidence: 99%

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Regional structural abnormalities in thalamus in idiopathic cervical dystonia

Luo,

Liu,

Zhong

et al. 2024

Preprint

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Background Although the thalamus has a central role in the pathophysiology of idiopathic cervical dystonia (iCD), the nature of the alterations occurring within this structure remain largely elusive. Using a structural magnetic resonance imaging (MRI) approach, we examined whether abnormalities differ across thalamic subregions/nuclei in patients with iCD. Methods Structural MRI data were collected from 37 patients with iCD and 37 healthy controls (HCs). Automatic parcellation of 25 thalamic nuclei in each hemisphere was performed based on the FreeSurfer program. Differences in thalamic nuclei volumes between groups and their relationships with clinical information were analyzed in patients with iCD. Results Compared to HCs, a significant reduction in thalamic nuclei volume primarily in central medial, centromedian, lateral geniculate, medial geniculate, medial ventral, paracentral, parafascicular, paratenial, and ventromedial nuclei was found in patients with iCD (P < 0.05, false discovery rate corrected). However, no statistically significant correlations were observed between altered thalamic nuclei volumes and clinical characteristics in iCD group. Conclusion This study highlights the neurobiological mechanisms of iCD related to thalamic changes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Regional structural abnormalities in thalamus in idiopathic cervical dystonia

Luo,

Liu,

Zhong

et al. 2024

Preprint

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“…Zhuang also recorded activity in the STN of dystonic patients and observed reduced rate and irregular bursts (Zhuang et al 2004). Devetiarov et al (2017) have recorded activity on the ventral oral nucleus of the thalamus (Voi) and surrounding areas in patients with cervical dystonia and compared it to activity in the ventro-intermediate nucleus of the thalamus (Vim) in PD patients. Those patients were undergoing thalamotomy to treat their movement disorders.…”

Section: Single-cell Recordingsmentioning

confidence: 99%

“…They identified single and burst pattern activities in all areas. They could not identify a disease specific pattern but there was a suggestion that Voa-Vop neurons in the surrounding areas were more hyperpolarised in dystonia because of the inhibitory pallidal outflow (Devetiarov 2017 ).…”

Section: Oscillatory Activity Recordings: Local Field Potentials Micmentioning

confidence: 99%

Neurophysiological insights in dystonia and its response to deep brain stimulation treatment

Tisch

Limousin

2020

Exp Brain Res

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Dystonia is a movement disorder characterised by involuntary muscle contractions resulting in abnormal movements, postures and tremor. The pathophysiology of dystonia is not fully understood but loss of neuronal inhibition, excessive sensorimotor plasticity and defective sensory processing are thought to contribute to network dysfunction underlying the disorder. Neurophysiology studies have been important in furthering our understanding of dystonia and have provided insights into the mechanism of effective dystonia treatment with pallidal deep brain stimulation. In this article we review neurophysiology studies in dystonia and its treatment with Deep Brain Stimulation, including Transcranial magnetic stimulation studies, studies of reflexes and sensory processing, and oscillatory activity recordings including local field potentials, micro-recordings, EEG and evoked potentials.

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