Neuronal activities during palatable food consumption in the reward system of binge-like eating female rats

Amissah, Richard Quansah; Basha, Diellor; Bukhtiyarova, Olga; Timofeeva, Elena; Timofeev, Igor

doi:10.1016/j.physbeh.2021.113604

Cited by 12 publications

(8 citation statements)

References 66 publications

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“…In contrast, greater drinking levels overall were related to more cells with a phenotype of sustained decreases in firing (SDP) during intake, similar to some other work linking consumption to reduced neuronal firing (e.g. [51,52] but see [53,54]). However, firing in SDP cells returned to baseline during pauses in licking, while IRP and SIP licking-related firing changes were maintained during pauses in licking, suggesting that IRP and SIP contributed to the overall action strategy for alcohol consumption, while SDP cells were more related to actual licking.…”

Section: Introductionsupporting

confidence: 78%

“…Thus, a priori, IRP and SIP were more likely candidates for encoding a main CLAD action strategy, with SDP more related to actual licking activity. In this regard, binge-prone rats (more prone to palatable food binging) have greater activity in several regions during pauses in licking, when compared to binge-resistant rats, which the authors interpret as maintained expectation for reward in food bingers [54]. Also, in our previous studies, the timing of the first lick of a session did not differ across drinking conditions, but, after the first lick occurred, responding happened significantly sooner under CLAD versus AOD; in addition, under moderate challenge, many aspects of lick responding became less variable, and while some aspects of reduced variability were retained under higher challenge, others were lost in concert with reduced intake [27,41].…”

Section: Discussionmentioning

confidence: 99%

“…[51,52]) but not all (e.g. [53,54]). Such studies vary in a number of factors, including food deprivation and the nature of the food reward (sometimes highly palatable).…”

Section: Discussionmentioning

confidence: 99%

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Anterior insular cortex firing links initial and sustained encoding during aversion-resistant alcohol consumption

Starski

Morningstar

Katner

et al. 2022

Preprint

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Compulsive-like alcohol drinking (CLAD), where intake persists despite adverse consequences, is often a core facet of alcohol use disorder. Recent work sheds light on underlying mechanisms, but much remains unknown about CLAD etiology. Previously, we showed that projections from anterior insula (aINS), a central mediator of emotion, motivation, and interoception, promote CLAD in rodents, and heavy human drinkers exhibit similar insula-circuit recruitment under compulsion-like conditions. However, global aINS inhibition also reduces alcohol-only drinking (AOD), and one major obstacle is the lack of information on aINS firing patterns that could promote different aspects of intake. Here, we recorded single-unit activity in right aINS from 15 rats during AOD or CLAD (10mg/L or 60mg/L quinine in alcohol). Neurons with a sustained-increase or sustained-decrease phenotype (SIP, SDP) showed no firing differences across drinking conditions. In contrast, aINS neurons with a phenotype of strong firing increase at initiation of responding (IRP) showed significantly greater activity across the rest of licking during CLAD versus AOD, concurring with our previous behavioral findings suggesting quick evaluation and response strategy adjustment under CLAD. There were also no condition-related differences in firing-phenotype abundance. Further, total responding only correlated with abundance of SDP cells, but SDP firing returned to baseline during pauses in licking, while IRP and SIP sustained responding through pauses in licking. Thus, only aINS cells with a particular strong firing at licking onset showd greater sustained responding under compulsion-like conditions, while other cells likely promoted drinking more generally, providing critical new information about how aINS activity could promote alcohol consumption under different drinking conditions.

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Section: Introductionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

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Anterior insular cortex firing links initial and sustained encoding during aversion-resistant alcohol consumption

Starski

Morningstar

Katner

et al. 2022

Preprint

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“…[38][39][40] Moreover, female rats exhibited a stronger conditioned place preference for palatable food than males and displayed higher palatable food-induced neural activity in the brain reward system than males. 40,41 Our findings showed that selective CB2 cannabinoid receptor agonists, BCP, and JWH-133, attenuated the incentive salience ("wanting") to seek a sweet reward in the runway task in food-fasted female mice. The effects of BCP were prevented by pretreatment with a selective CB2 receptor antagonist (AM630).…”

Section: Discussionmentioning

confidence: 70%

“…Additionally, female rats are more likely to have binge eating behaviour than male rats 38–40 . Moreover, female rats exhibited a stronger conditioned place preference for palatable food than males and displayed higher palatable food‐induced neural activity in the brain reward system than males 40,41 …”

Section: Discussionmentioning

confidence: 99%

β‐caryophyllene, a cannabinoid receptor 2 agonist, decreases the motivational salience and conditioning place preference for palatable food in female mice

et al. 2022

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β-caryophyllene (BCP) is a cannabinoid receptor CB2 agonist plant-derived terpenoid found in different essential oil plants, including rosemary, black pepper, copaiba and cannabis. It has GRAS (generally recognized as safe) status and is approved by the FDA (Food and Drug Administration) for food use. BCP displays agonist activity on the CB2 receptor and is a potential therapeutic target in several neuropsychiatric disorders, including anxiety and drug addiction. Unlike CB1 receptors, activation of the CB2 receptors is devoid of psychotomimetic and addictive properties. In this regard, this study aimed to evaluate the effects of BCP on incentive salience ("wanting") performance and motivational properties elicited by sweetened palatable foods in female Swiss mice. After 9 days of training for incentive salience performance for a sweet reward (hazelnut cream with chocolate), food-restricted mice received a systemic injection of BCP (50 and 100 mg/kg) before testing over 3 days. Moreover, independent groups of female mice were tested on sweet reward-induced conditioned place preference (CPP) for 22 consecutive days. To evaluate BCP effects on the expression of seeking behaviour for sweetened food, mice received a single intraperitoneal injection of BCP (50 mg/kg) 30 min before testing on the CPP task. BCP significantly decreased the incentive performance for a sweet reward compared with the control group in a CB2 receptor-dependent manner. Also, BCP suppressed the expression of sweet reward-CPP. Altogether, these preclinical data demonstrate the potential role of BCP in treating disorders associated with food addiction-like behaviour.

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DeltaFosB and Preclinical Binge Eating

Amissah

Timofeev

2022

Eating Disorders

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Neuronal activities during palatable food consumption in the reward system of binge-like eating female rats

Cited by 12 publications

References 66 publications

Anterior insular cortex firing links initial and sustained encoding during aversion-resistant alcohol consumption

Anterior insular cortex firing links initial and sustained encoding during aversion-resistant alcohol consumption

β‐caryophyllene, a cannabinoid receptor 2 agonist, decreases the motivational salience and conditioning place preference for palatable food in female mice

DeltaFosB and Preclinical Binge Eating

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