Neuron-specific enolase and S100B protein in children with carbon monoxide poisoning: children are not just small adults

Akelma, Ahmet Zülfikar; Çelik, Aydın; Özdemir, Osman; Akelma, Fatma Kavak; Abacı, Ayhan; Razi, Cem Hasan; Kışlal, Fatih Mehmet; Akın, Okhan

doi:10.1016/j.ajem.2012.10.009

Cited by 13 publications

(10 citation statements)

References 19 publications

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“…neuroblastoma, medullary thyroid cancer, endocrine tumors of pancreas and melanoma. Also, it is increased in traumatic and hypoxic brain damage, status epilepticus and cardiac arrest (Akelma et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

A Prospective Comparative Study between Three Chemical Markers for Predicting Delayed Neurological Sequelae in Patients with Acute Carbon Monoxide Poisoning of Poison Control Center in Minia University Hospital.

Hassan

Abdelaleem

Hamdy

2018

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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Carbon monoxide poisoning (CO) is a major public health problem. Brain is the most sensitive organ to hypoxia induced by CO poisoning. Delayed Neurological Sequelae (DNS) is considered to be a delayed onset of neuropsychiatric symptoms after apparent recovery from acute CO poisoning. Therefore, this study was aimed to make a prospective comparative study between three markers (serum glutathione reductase, S100b protein and serum neurone-specific enolase) to predict the occurrence of DNS. This study was performed on 57 adult patients with acute CO poisoning. The markers were measured after arrival and the patients were divided into two groups: the DNS group (8 patients) & the non-DNS group (49 patients). There was a statistical difference between the two groups in terms of significant increase in loss of consciousness, syncope, dizziness, ECG changes, pneumonia, carboxyhemoglobin level, creatine phosphokinase, creatine phosphokinase-MB, troponin I, S100b protein, neurone-specific enolase in DNS grouped patiens and significant decrease in glasgow coma scale and glutathione reductase in DNS group. The cut off value of glutathione reductase was ≤ 30 U/L with a percentage of accuracy 94. 74. The cut off value of S100b protein was > 18.94 Pg/ L with 98.25 % percentage of accuracy, while, the cut off value of neurone-specific enolase was > 30.49 ng/ml and its accuracy was 96.49 %. All these cut off values predicted the occurrence of DNS. SO, it is concluded that serum S100b protein may represent the most reliable chemical marker for the prediction of DNS after acute CO poisoning by logistic regression analysis.

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Section: Discussionmentioning

confidence: 99%

A Prospective Comparative Study between Three Chemical Markers for Predicting Delayed Neurological Sequelae in Patients with Acute Carbon Monoxide Poisoning of Poison Control Center in Minia University Hospital.

Hassan

Abdelaleem

Hamdy

2018

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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“…Originated from the brain, NSE is a protein commonly used to assess the presence and severity of neurological injury. 35 Higher levels of serum NSE reported in patients with silicosis, 36 mercury intoxication, 37 pneumoconiosis, 38 and those exposed to chromium 9 and carbon-monoxide 39 . Lower levels of serum NSE were reported in workers exposed to organic solvents, 8 and patients with major depressive and bipolar affective disorders.…”

Section: Discussionmentioning

confidence: 99%

Serum Neuron-Specific Enolase, Biogenic Amino-Acids and Neurobehavioral Function in Lead-Exposed Workers from Lead-Acid Battery Manufacturing Process

Kalahasthi¹,

Barman²,

Rajmohan³

2015

Int J Occup Environ Med

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“…Neuron-specific enolase (NSE) is a glycolytic enzyme that is localized primarily to the neuronal cytoplasm in the central nervous system. S100B is a calcium-binding protein localized to astroglial cells [30]. They are both released after hypoxic damage as a result of neuronal and astroglial cell death [31].…”

Section: Long-term Sequelae and Prognosticationmentioning

confidence: 99%

“…Further larger and long-term studies including more people with severe poisoning are required to clarify the optimal timing and threshold and the extent to which a normal S100B can be regarded as reassuring with respect to long-term prognosis. In general, results for NSE have shown a less obvious relationship to severity than S100B [33,34], although one study found that it was better linked to level of consciousness and also had a longer apparent half-life [30]. No studies to date have examined the relationship between NSE elevation and long-term sequelae.…”

Section: Long-term Sequelae and Prognosticationmentioning

confidence: 99%

Carbon monoxide poisoning in the 21st century

Chiew

Buckley

2014

Crit Care

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The world has experienced some very large shifts in the epidemiology of carbon monoxide poisoning, but it remains one of the most important toxicological global causes of morbidity and mortality. The diagnosis can be quickly confirmed with blood gases (pulse oximeters lack both sensitivity and specificity). Several strong predictors for serious neurological sequelae (prolonged loss of consciousness and elevated S100B) and reduced life expectancy (elevated troponin) are now reasonably well established. Despite this clearly defined high-risk group and extensive research into the pathophysiology, there has been little translation into better treatment. Much of the pathophysiological research has focused on hyperbaric oxygen. Yet it is apparent that clinical trials show little evidence for benefit from hyperbaric oxygen, and the most recent even raises the possibility of harm for repeated courses. More logical and promising potential antidotes have been under-researched, although recently both animal and small human studies suggest that erythropoietin may reduce S100B and prevent neurological sequelae. Major breakthroughs are likely to require further research on this and other treatments that may inhibit post-hypoxic inflammatory responses and apoptosis.

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Neuron-specific enolase and S100B protein in children with carbon monoxide poisoning: children are not just small adults

Cited by 13 publications

References 19 publications

A Prospective Comparative Study between Three Chemical Markers for Predicting Delayed Neurological Sequelae in Patients with Acute Carbon Monoxide Poisoning of Poison Control Center in Minia University Hospital.

A Prospective Comparative Study between Three Chemical Markers for Predicting Delayed Neurological Sequelae in Patients with Acute Carbon Monoxide Poisoning of Poison Control Center in Minia University Hospital.

Serum Neuron-Specific Enolase, Biogenic Amino-Acids and Neurobehavioral Function in Lead-Exposed Workers from Lead-Acid Battery Manufacturing Process

Carbon monoxide poisoning in the 21st century

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