Neuromyelitis optica in Sub-Saharan Africa: the first case report from Togo

Apétsè, Kossivi; Assogba, Komi; Diatewa, Josué Euberma; Tajeuna, J.J. Dongmo; Maneh, Nidain; Kayem, F.M. Tassa; Kombaté, Damelan; Balogou, Koffi Agnon

doi:10.1684/mst.2018.0764

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, a number of case reports, including reports from countries not represented in our review, have been published (Burkina Faso, Ghana, South Africa, Uganda, Nigeria, and Togo). 46,54-60,e1-e6 Prospective data are scarce, and most studies were retrospective in nature, with inclusion criteria that varied over time in accordance with evolving diagnostic criteria of NMO and NMOSD. 11…”

Section: Discussionmentioning

confidence: 99%

Neuromyelitis Optica Spectrum Disorders in Africa

Musubire

Derdelinckx

Reynders

et al. 2021

Neurol Neuroimmunol Neuroinflamm

View full text Add to dashboard Cite

Background and ObjectivesNeuromyelitis optica (NMO) is a CNS inflammatory disease that predominantly affects the optic nerves and the spinal cord. It is more frequent in Asian and African populations than in European ones. Data on epidemiology, clinical presentation, additional investigations, and treatment in the African continent are scarce. We aim to (1) collect and analyze published data on neuromyelitis optica spectrum disorder (NMOSD), (2) indicate challenges in the diagnosis and management, and (3) discuss opportunities for future research, education, and policy making, specifically on the African continent.MethodsA systematic review was performed in January 2021 with the search terms “Neuromyelitis optica and Africa,” “Devic Disease and Africa,” and “NMOSD and Africa.” We included all study types except case reports, correspondence, or conference abstracts on NMO or NMOSD. Extracted data included study design, country, study period, demographic and clinical characteristics, results of paraclinical investigations, and outcome. Data analysis was performed with descriptive statistics.ResultsWe retrieved a total of 79 records, of which 19 were included. Ten of 54 African countries reported a total of 410 cases. Almost half of them were from North African countries. The mean age at diagnosis was 33 years (range 7–88 years), and 75% were female. Transverse myelitis followed by optic neuritis were the most frequent symptoms at the time of presentation. One hundred nineteen patients experienced at least 1 previous relapse, and 106 had a relapsing course after diagnosis. Relapses were treated with IV methylprednisolone. Azathioprine and steroids were used most often as maintenance treatments. Outcomes were rarely described.DiscussionThe majority of studies on NMOSD from the African continent are retrospective, and most countries do not report any data. Our systemic review shows that data derived from patients living in Africa correspond well to what has been previously published in meta-analyses on patients of African ancestry with NMOSD who live outside of Africa, except for a younger age at onset and a lower proportion of females. We advocate for systematic data collection to adequately capture and monitor the burden of NMOSD, for expansion of research efforts and facilities to perform fundamental and clinical research, and for improved access to health care including diagnostics, treatments, and rehabilitation services for people affected by NMOSD in the African continent.

show abstract

Section: Discussionmentioning

confidence: 99%

Neuromyelitis Optica Spectrum Disorders in Africa

Musubire

Derdelinckx

Reynders

et al. 2021

Neurol Neuroimmunol Neuroinflamm

View full text Add to dashboard Cite

show abstract

“…Since Osuntokun in Nigeria in 1970, 8 cases of NMO/NMOSD have been reported in black African countries. 9 10 11 12 13 14 In Togo, nearly 55% of the population lives in multidimensional poverty, the guaranteed interprofessional minimum wage (GIMW) is 35,000 CFA francs ($US64), while the rate of health insurance coverage is estimated at nearly 5%. We conducted a hospital-based study with the objective of describing possible peculiarities of NMOSD in our setting.…”

Section: Introductionmentioning

confidence: 99%

Neuromyelitis Optica Spectrum Disorders in Black African: Experience of Togo (2015–2020)

Apétsè

Kouassi

Anayo

et al. 2022

JNRP

View full text Add to dashboard Cite

Introduction Neuromyelitis optica spectrum disorders (NMOSD) would disproportionately affect blacks within mixed populations. However, they are rarely reported in black African. The objective of this work was to report the experience of Togo, a West African country in terms of NMOSD. Methods This is a series of six cases diagnosed between 2015 and 2020 in the only three neurology departments in Togo. The diagnosis of NMOSD was made according to the criteria of the International Panel for NMO Diagnosis (2015) and the patients had a minimum clinical follow-up of 6 months after the diagnosis. The search for anti-aquaporin 4 (AQP4) antibodies was performed by immunofluorescence on transfected cells. Results The mean age was 25.33 years and the sex ratio female/male was 5/1. The average time between the first attack and the diagnosis was 122.83 days. Clinically, there was isolated medullary involvement (2/6), simultaneous opticomedullary involvement (3/6), and area postrema syndrome (1/6). Five patients were anti-AQP4 positive. All six patients had extensive longitudinal myelitis. At 6 months of follow-up, there was one case of death and one case of blindness. Conclusion The rarity of NMOSD cases in Togo could be linked to an underestimation. To better characterize the NMOSDs of the black African population, multicenter and multidisciplinary studies are necessary.

show abstract

Neuromyelitis optica in Sub-Saharan Africa: the first case report from Togo

Cited by 2 publications

References 0 publications

Neuromyelitis Optica Spectrum Disorders in Africa

Neuromyelitis Optica Spectrum Disorders in Africa

Neuromyelitis Optica Spectrum Disorders in Black African: Experience of Togo (2015–2020)

Contact Info

Product

Resources

About