“…Adverse events about vaccination-induced NMOSD have recently been constantly reported. Many studies describe trigger or relapses of NMOSD after vaccination (Table 1) (Mealy et al, 2018) (Esmanhotto et al, 2020) (Menge et al, 2012) (Furukawa et al, 2011) (Kitazawa et al, 2012) (Cho et al, 2019) (Schoberl et al, 2017) (Chang et al, 2016) (Kline et al, 1982). Among reported cases, HPV was one of the most common NMOSD-related vaccines, and four cases were reported after receiving Gardasil, a quadrivalent recombinant vaccine, containing the main capsid (L1) protein of human papillomavirus (HPV) types 6, 11, 16, and 18 in highly-purified virus-like particles (Menge et al, 2012).…”