Neuromuskuläre Komplikationen einer SARS-CoV-2-Infektion – Teil 1: periphere Nerven

Lehmann, Helmar C.; Schöser, Benedikt; Wunderlich, Gilbert; Berlit, Peter; Fink, Gereon R.

doi:10.1007/s00115-021-01094-0

Cited by 6 publications

(5 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Hinsichtlich des GBS als (akute) Folge einer COVID-19-Erkrankung erfolgte bereits vor Kurzem in Der Nervenarzt eine umfassende Zusammenstellung der bisher publizierten Daten [ 33 ]. Zusammengefasst sind aus der ersten Phase der Pandemie mehrere retrospektive Fallserien publiziert worden, die eine erhöhte Rate von GBS-Fällen in Regionen nahelegt, die besonders von COVID-19 betroffen waren, z.…”

Section: Neuromuskuläre Erkrankungen Nach Covid-19: Was Ist Gesichert?unclassified

“…Wie schon in den Übersichten über mögliche Folgen der Akutphase von COVID-19 beschrieben [ 33 , 34 ], sollen auch hier Evidenzkriterien zur Beurteilung der Kausalität angelegt werden, die 1965 von Hill (allerdings für arbeitsmedizinische Kausalitätsfragen) vorgeschlagen wurden [ 12 , 23 ] und aus insgesamt neun Merkmalen bestehen: Effektstärke, Konsistenz, Spezifität, zeitlicher Zusammenhang, biologischer Gradient, Plausibilität, Kohärenz, Experiment und Analogie (Tab. 2 ).…”

Section: Myalgien Und Pots Als Folge Von Long-covid? Versuch Einer Ob...unclassified

See 1 more Smart Citation

Neuromuskuläre Manifestationen beim Long-COVID-Syndrom

Lehmann

2022

Nervenarzt

Self Cite

View full text Add to dashboard Cite

Section: Neuromuskuläre Erkrankungen Nach Covid-19: Was Ist Gesichert?unclassified

Section: Myalgien Und Pots Als Folge Von Long-covid? Versuch Einer Ob...unclassified

Neuromuskuläre Manifestationen beim Long-COVID-Syndrom

Lehmann

2022

Nervenarzt

Self Cite

View full text Add to dashboard Cite

“…The SARS-CoV2 infection (1) has been correlated to neurological manifestations such as neuropathy, myopathy, Guillain-Barré syndrome, and central nervous system disorders (2)(3)(4). Neurological complaints after SARS-CoV2 infection resolution are common in studies, and the term post-acute COVID-19 syndrome (PACS) has been introduced to define this clinical entity.…”

Section: Introductionmentioning

confidence: 99%

Subclinical finding in the perception of tactile sensation involvement after SARS-CoV2 infection: comparison with healthy controls using Semmes–Weinstein monofilament testing

Tereshko,

Viotto,

Lettieri

et al. 2023

Front. Neurol.

View full text Add to dashboard Cite

BackgroundPost-acute COVID-19 syndrome patients complain of sensory alterations, mainly positive symptoms such as paresthesia or neuropathic pain but also decreased tactile sensation. Using the Semmes–Weinstein monofilament test (SWMT), our study aims to confront recently infected SARS-CoV2 subjects with a control group.MethodsThis is a cross-sectional, single-centric study. We performed the SWMT (North Coast Medical Inc.) on 30 patients with previous SARS-CoV2 infection (COVID group) and 46 controls (control group). These patients did not present comorbidities or sensory impairment and did not take any medications. The control group tested negative for SARS-CoV2 infection since the COVID-19 pandemic; the COVID group was examined for this study after the resolution of the infection. We tested the threshold of tactile sensation of the tips of the thumb, index, and little finger of each hand, one hand at a time; the dorsum and the hypothenar regions were also tested.ResultsBoth groups presented the perception of tactile sensation within the reference value. Despite this result, subclinical changes suggestive of the involvement in peripheral sensory nerve function have been identified in the tested sites in the COVID group compared to the control group. The overall mean target force (grams) was higher in the COVID group than in the control group: 27 (7) vs. 19 (10) mg, p < 0.001.ConclusionControls and the COVID group infection had normal tactile sensation thresholds. However, the COVID group presented a higher threshold than the control group, suggesting a possible subclinical perception of tactile sensation involvement of A-beta nerve fibers.

show abstract

“…Moreover, no correlation between a specific preceding infection and MG has been documented [1]. The SARS-CoV-2 virus infection [2] has been correlated to several neurological manifestations, including neuropathy, myopathy, Guillain-Barré syndrome, anosmia, ageusia, and neuromuscular disorders [3]. Few cases of New-onset Myasthenia Gravis after COVID-19 have been reported [4][5][6][7][8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

New-onset Myasthenia Gravis after SARS-CoV-2 infection: case report and literature review

et al. 2022

View full text Add to dashboard Cite

We report the case of a 19-year-old female patient who developed Myasthenia Gravis 13 days after SARS-CoV-2 infection with positive RT-PCR testing. Her symptoms initially involved the oculo-bulbar district, but they gradually worsened in 3 months converting into a generalized form of Myasthenia Gravis complicated with a myasthenic crisis. A high level of anti-acetylcholine receptor antibodies was found in the serum, while anti-MuSK antibodies were negative; Repetitive Nerve Stimulation and Single-fiber Electromyography were suggestive of Myasthenia Gravis. Intravenous immunoglobulin courses and specific therapy were able to improve her symptoms, but thymic resection was needed to control the disease. This is a report of new-onset Myasthenia Gravis correlated to COVID-19 in which thymic resection was described and the histologic analysis of the thymus was performed showing thymic hyperplasia despite negative thoracic Magnetic Resonance Imaging. SARS-CoV-2 infection releases inflammatory cytokines that could dysregulate the immune system and lead to Myasthenia Gravis in susceptible subjects.

show abstract

Neuromuskuläre Komplikationen einer SARS-CoV-2-Infektion – Teil 1: periphere Nerven

Cited by 6 publications

References 54 publications

Neuromuskuläre Manifestationen beim Long-COVID-Syndrom

Neuromuskuläre Manifestationen beim Long-COVID-Syndrom

Subclinical finding in the perception of tactile sensation involvement after SARS-CoV2 infection: comparison with healthy controls using Semmes–Weinstein monofilament testing

New-onset Myasthenia Gravis after SARS-CoV-2 infection: case report and literature review

Contact Info

Product

Resources

About