Neuromuscular morphometry of the uterine ligaments and vaginal wall in women with pelvic organ prolapse

Kaplan, Petek Balkanlı; Usta, Ufuk; İnal, Hasan Ali; Tastekin, Tugba; Tokuç, Burcu

doi:10.1002/nau.20972

Cited by 17 publications

(17 citation statements)

References 31 publications

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“…Many other reports have published concordant results with the study by Boreham et al (Table 3) [27][28][29][30]. The fraction of smooth muscle in the muscularis of the anterior vaginal wall was significantly decreased in women with POP and there was no significant difference between primary and recurrent cases.…”

Section: Morphometric Analysis Of the Vaginal Wallsupporting

confidence: 78%

“…By evaluating the anterior vaginal wall innervation using PGP 9.5, Inal et al observed a decreased number and diameter of the subepithelial nerve fibers in the anterior vaginal wall of women with anterior prolapse than in women with normal vaginal support [29]. Kaplan et al recently confirmed their findings by describing decreased neuronization in the vaginal wall in the POP group [30].…”

Section: Innervation Of the Vaginal Wallmentioning

confidence: 97%

“…Measurement of the distance between the surface epithelium and the nearest point of the muscularis have also been used to analyze changes in the vaginal tissue of women with or without POP [29,30]. The mean distance of the smooth muscle fibers from the surface epithelium of the prolapsed group was significantly higher than in the control group.…”

Section: Morphometric Analysis Of the Vaginal Wallmentioning

confidence: 99%

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Histology of the vaginal wall in women with pelvic organ prolapse: a literature review

et al. 2013

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Introduction and hypothesis The pathophysiology of pelvic organ prolapse (POP) is incompletely understood. The purpose of this study is to describe the current knowledge about histology of the vaginal wall and its possible involvement in the pathogenesis of pelvic organ prolapse. Methods Eligible studies were selected through a MEDLINE search covering January 1986 to December 2012. The research was limited to English-language publications. Results Investigations of changes in the vaginal tissue that occur in women with genital prolapse are currently still limited and produced contrary results. The heterogeneity of the patients and the control groups in terms of age, parity and hormonal status, of the localization of biopsies and the histological methods as well as the lack of validation of the quantification procedures do not allow clear and definitive conclusions to be drawn. Conclusions This review shows that current knowledge of the histological changes observed in women with POP are inconclusive and relatively limited. More studies are needed in this specific field to better understand the mechanisms that lead to POP.

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Section: Morphometric Analysis Of the Vaginal Wallsupporting

confidence: 78%

Section: Innervation Of the Vaginal Wallmentioning

confidence: 97%

Section: Morphometric Analysis Of the Vaginal Wallmentioning

confidence: 99%

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Histology of the vaginal wall in women with pelvic organ prolapse: a literature review

et al. 2013

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“…Pelvic floor muscles, uterosacral ligaments and endopelvic fascia represent the anatomical support for female pelvic organs, and their histological modifications could play a crucial role in the pathophysiology of the disease Kaplan et al 2011;Vulic et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Neurovascular alterations of muscularis propria in the human anterior vaginal wall in pelvic organ prolapse

Sferra

Pompili

et al. 2019

Journal of Anatomy

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In the pathophysiology and progression of pelvic organ prolapse (POP), it has been demonstrated that there is a reorganisation of the muscularis propria of the anterior vaginal wall due to a phenotypic smooth muscle cell to myofibroblast switch. An abnormal deposition of collagen type III seems to be influenced by the involvement of advanced glycation end‐products. The aim of the present study was to evaluate the hypothesis that this connective tissue remodelling could also be associated with neurovascular alterations of the muscularis in women with POP compared with control patients. We examined 30 women with POP and 10 control patients treated for uterine fibromatosis. Immunohistochemical analysis, using glial fibrillary acidic protein, S‐100 protein, receptor tyrosine kinase, neurofilament and α‐smooth muscle actin antibodies, was performed. S‐100, receptor tyrosine kinase and neurofilament were also evaluated using Western blot analysis. We observed a decrease in all neurovascular‐tested markers in nerve bundles, ganglia and interstitial cells of Cajal from POP samples as compared with controls. Even if the processes responsible for these morphological alterations are still not known, it is conceivable that collagen III deposition in the anterior vaginal wall affects not only the architecture of the muscle layer but could also modify the intramuscular neurovascularisation and account for an alteration of the neuromuscular plasticity of the layer.

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“…In , one of the coauthors of the article has an incorrect first name given in the byline. The correct name is Ebru Tastekin, not Tugba Tastekin.…”

mentioning

confidence: 99%

Erratum

2014

Neurourology and Urodynamics

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Neuromuscular morphometry of the uterine ligaments and vaginal wall in women with pelvic organ prolapse

Abstract: Both total innervation of the anterior vaginal epithelium and uterine ligaments, and muscular percentage of the round ligament and vaginal wall were decreased in women with pelvic organ prolapse.

Cited by 17 publications

References 31 publications

Histology of the vaginal wall in women with pelvic organ prolapse: a literature review

Histology of the vaginal wall in women with pelvic organ prolapse: a literature review

Neurovascular alterations of muscularis propria in the human anterior vaginal wall in pelvic organ prolapse

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