Neuromuscular Effects of Bw1090u in Patients Under Narcotic-N2o Anesthesia

Lee, C.; Cheng, Mary Ann; Yang, E.; Cantley, E.; Harris, William A.; Weakly, J. N.; Whitehead, Bruce

doi:10.1097/00000542-198709001-00354

Anesthesiology

1987

DOI: 10.1097/00000542-198709001-00354

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Neuromuscular Effects of Bw1090u in Patients Under Narcotic-N2o Anesthesia

C. Lee¹,

Mary Ann Cheng²,

E. Yang³

et al.

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Cited by 3 publications

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“…(8) have reported 0.12 mg/kg as the MIV ED,,.Weber et al (9) also reported difficulties in reconfirming the currently reported ED,,(9). The rapid acceptance of 0.75 mg/kg as the ED,, of MIV, and the clinical trend to administer twice this dose to speed the intubation time, have misled many authors into having no interest in reconfirming the previous assumption.Since the ED,, is a relevant value for several clinical procedures and pharmacologic calculations, further studies are required to clarify this disparity.…”

mentioning

confidence: 98%

Mivacurium ED95 Recalculated

Silverman

Brull

1994

Anesthesia & Analgesia

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Review (non-peer review). We conducted the most recent study of the magnetic intubation technique in order to assess the strength of the magnet required to guide the ferrous stylet with a two-part intubation catheter. A literature search of the period between 1970 and 1994 was conducted. However, since the article by Obolentsev et al., cited by Spencer and Abajian, was published originally in Russian, it was not identified in our search. Furthermore, this article, describing a magnetic device directing an endotracheal tube containing metallic balls in the distal end, was published in 1987, 6 yr after our technique was first introduced. The only technique similar to ours was that in which the magnet was placed over the neck to attract the tip of an endotracheal tube that was either impregnated with a ferrous substance or inserted with a ferrous plug. This technique was patented by R. D. McKenne on December 20,1977. Since we never had the intention of patenting our idea, we did not conduct a patent search, and, therefore, the technique of McKenne was not identified. Thus, the question arises: to what extent must one spend time and money to conduct unnecessary patent searches and costly, multiple-language, literature searches?

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mentioning

confidence: 98%

Mivacurium ED95 Recalculated

Silverman

Brull

1994

Anesthesia & Analgesia

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“…Mivacurium chloride (BW B1090U), a new shortacting non-depolarizing neuromuscular blocking drug, has undergone initial clinical trials to evaluate its neuromuscular and cardiovascular effects [1][2][3][4][5][6][7]. Mivacurium is metabolized by pseudocholinesterase at a rate 70% of that of suxamethonium [8].…”

mentioning

confidence: 99%

Comparison of Mivacurium and Suxamethonium Administered by Bolus and Infusion

Brandom¹,

Woelfel²,

Cook³

et al. 1989

British Journal of Anaesthesia

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Mivacurium chloride is a new, short-acting nondepolarizing neuromuscular blocking agent presently undergoing clinical evaluation. The neuromuscular effects of mivacurium and suxamethonium given by bolus and infusion were compared in adult patients during nitrous oxide-oxygen-opioid anaesthesia. Neuromuscular block was monitored by recording the compound electromyogram of the adductor pollicis muscle resulting from supramaximal train-of-four stimuli applied to the ulnar nerve. Time to onset of complete block and recovery to T5 were significantly shorter for suxamethonium than for mivacurium (1.0 (0.1) v. 2.5 (0.3) min and 6.4 (0.7) v. 17.5 (1.8) min; mean (SEM]. Conditions for tracheal intubation were similar in the two groups although intubation was performed 0.75-1.3 min later following mivacurium. The infusion rate required to maintain neuromuscular block was 88.6 (10.4) micrograms kg-1 min-1 for suxamethonium and 7.8 (1.2) micrograms kg-1 min-1 for mivacurium. There was a significant negative correlation between recovery to T5 and infusion rate for mivacurium and for suxamethonium. It was equally easy to titrate the infusion rate to the desired degree of block in each group. The recovery index (T25-T75) after the infusion stopped was similar in patients who received mivacurium and those who received suxamethonium.

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What’s New in Skeletal Muscle Relaxants and Their Antagonists?

Shanks

1988

Anesthesiology Clinics of North America

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Neuromuscular Effects of Bw1090u in Patients Under Narcotic-N2o Anesthesia

Cited by 3 publications

References 0 publications

Mivacurium ED95 Recalculated

Mivacurium ED95 Recalculated

Comparison of Mivacurium and Suxamethonium Administered by Bolus and Infusion

What’s New in Skeletal Muscle Relaxants and Their Antagonists?

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