Neuromuscular blocking effects of vecuronium in dogs with autosomal-recessive centronuclear myopathy

Martin‐Flores, Manuel; Paré, Monique D.; Tomak, Emily A.; Corn, Morgan L.; Campoy, Luis

doi:10.2460/ajvr.76.4.302

Cited by 5 publications

(4 citation statements)

References 20 publications

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“…X-linked myotubular myopathy and CNM have been extensively described in both humans and dogs, with the Labrador retriever serving as a valuable model for the human disease for decades. 2,[17][18][19][20][21][22][23][24][25] The condition also has been reported in other dog breeds (including Boykin spaniels, Great Danes, Rottweilers, and a Border collie), an Arabian-cross foal, and Japanese Black calves. 4,7,8,26,27 The main differential diagnosis initially considered given the clinical presentation, age of onset, and signalment was SMA, which has been well-described in Maine coon cats.…”

Section: Discussionmentioning

confidence: 93%

“…This case represents the first report of a gene variant likely resulting in XLMTM in cats. X‐linked myotubular myopathy and CNM have been extensively described in both humans and dogs, with the Labrador retriever serving as a valuable model for the human disease for decades 2,17‐25 . The condition also has been reported in other dog breeds (including Boykin spaniels, Great Danes, Rottweilers, and a Border collie), an Arabian‐cross foal, and Japanese Black calves 4,7,8,26,27 …”

Section: Discussionmentioning

confidence: 99%

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X‐linked myotubular myopathy associated with an MTM1 variant in a Maine coon cat

Kopke

Shelton

Lyons

et al. 2022

Veterinary Internal Medicne

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Objective Describe the clinical course and diagnostic and genetic findings in a cat with X‐linked myotubular myopathy. Case Summary A 7‐month‐old male Maine coon was evaluated for progressively worsening gait abnormalities and generalized weakness. Neurolocalization was to the neuromuscular system. Genetic testing for spinal muscular atrophy (LIX1) was negative. Given the progressive nature and suspected poor long‐term prognosis, the owners elected euthanasia. Histopathology of skeletal muscle obtained post‐mortem disclosed numerous rounded atrophic or hypotrophic fibers with internal nuclei or central basophilic staining. Using oxidative reactions mediated by cytochrome C oxidase and succinic dehydrogenase, scattered myofibers were observed to have central dark staining structures and a “ring‐like” appearance. Given the cat's age and clinical history, a congenital myopathy was considered most likely, with the central nuclei and “ring‐like” changes consistent with either centronuclear or myotubular myopathy. Whole genome sequencing identified an underlying missense variant in myotubularin 1 (MTM1), a known candidate gene for X‐linked myotubular myopathy. New or Unique Information Provided This case is the first report of X‐linked myotubular myopathy in a cat with an MTM1 missense mutation. Maine coon cat breeders may consider screening for this variant to prevent production of affected cats and to eradicate the variant from the breeding population.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

X‐linked myotubular myopathy associated with an MTM1 variant in a Maine coon cat

Kopke

Shelton

Lyons

et al. 2022

Veterinary Internal Medicne

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“…In recent human studies, many reports have evaluated AMG-based neuromuscular monitoring when administering neuromuscular blocking agents, but there are few veterinary studies (10,11,23). Therefore, one of the limitations of this study is that few studies can be directly compared in dogs as an adjuvant to local anesthetic in mandibular nerve block.…”

Section: Discussionmentioning

confidence: 98%

Effectiveness of Tramadol and Butorphanol as an Adjuvant to Local Anesthetic in Mandibular Nerve Block in Beagle Dogs

et al. 2022

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To evaluate butorphanol and tramadol as adjuvants to lidocaine in dogs undergoing mandibular nerve block. Fifteen beagles were allocated to groups based on the following treatments: lidocaine alone (L group), lidocaine + butorphanol (LB group), or lidocaine + tramadol (LT group). After mandibular nerve block with opioids as an adjunct to local anesthetics, the onset time, duration of action, and depth of anesthesia were evaluated using a quantitative method through neuromuscular blockades (NMBs) monitoring. The onset time of nerve block was 4.60 ± 2.06 min, 2.00 ± 0.00 min, and 2.60 ± 1.62 min in the L, LB, and LT groups, respectively; however, there was no statistically significant difference. The duration of nerve block was 111.88 ± 34.78 min, 302.00 ± 76.72 min, and 260.40 ± 49.88 min in the L, LB, and LT groups, respectively, with a significant difference between L and LB groups. The LB group demonstrated a more profound depth of anesthesia compared to the L and LT groups. In this study, using a quantitative method through NMBs monitoring, it was demonstrated that lidocaine and butorphanol in combination can increase the duration of nerve block and more profound the depth of anesthesia rather than lidocaine alone. Additionally, the combined use of lidocaine and opioids presented an objective indicator that could provide a more clinically stable nerve block.

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“…This is in accord with an earlier study where the spontaneous recovery to a TOF ratio ≥0.9 did not differ between dogs with CNM and a matched control group of normal Labrador retriever dogs, after administration of vecuronium 0.1 mg kg −1 . 13 While spontaneous recovery from non-depolarizing block may depend on redistribution and/or biotransformation, pharmacological antagonism with neostigmine relies on the release and accumulation of ACh at the endplate. Recovery to a TOF ratio ≥0.9 after administration of neostigmine was approximately 40% (5 min) slower in dogs with CNM.…”

Section: Discussionmentioning

confidence: 99%

Neuromuscular blocking effects of cisatracurium and its antagonism with neostigmine in a canine model of autosomal-recessive centronuclear myopathy

Martin‐Flores

Paré

Campoy

et al. 2015

British Journal of Anaesthesia

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Neuromuscular blocking effects of vecuronium in dogs with autosomal-recessive centronuclear myopathy

Abstract: For the study dogs, neither potency nor duration of vecuronium-induced neuromuscular blockade was altered by CNM. Vecuronium can be used to induce neuromuscular blockade in dogs with autosomal-recessive CNM.

Cited by 5 publications

References 20 publications

X‐linked myotubular myopathy associated with an MTM1 variant in a Maine coon cat

X‐linked myotubular myopathy associated with an MTM1 variant in a Maine coon cat

Effectiveness of Tramadol and Butorphanol as an Adjuvant to Local Anesthetic in Mandibular Nerve Block in Beagle Dogs

Neuromuscular blocking effects of cisatracurium and its antagonism with neostigmine in a canine model of autosomal-recessive centronuclear myopathy

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