Neuromuscular Blocking and Hypotensive Actions of Streptomycin, and Their Reversal

Pandey, Kanti Bhooshan; Kumar, Sanjay; Badola, R.P.

doi:10.1093/bja/36.1.19

Cited by 11 publications

(9 citation statements)

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“…Depression of systemic blood pressure in man has also been observed by several investigators after the administration of other chemically related antibiotics (3,9,24). Although several mechanisms (e.g., negative inotropic and chronotropic effects on the myocardium [3,18,28], autonomic ganglionic blockade [4,5,21], and respiratory depression [21,25] as well as a direct depolarizing action on the smooth muscle cell membrane. Thus, it would appear that suppression of vascular smooth muscle contractility by aminoglycoside antibiotics involves a rather nonspecifc inhibitory mechanism.…”

Section: Discussionmentioning

confidence: 94%

“…Depression of cardiovascular function by antimicrobial agents has been the subject of several controlled laboratory studies involving nonhuman animals (3,18,20,21,28). Apparently, this adverse drug response occurs infrequently during therapeutic situations in man (3,28); however, occasional clinical reports have associated the aminoglycoside group of antibiotics with unusual hemodynamic responses.…”

Section: Discussionmentioning

confidence: 99%

“…Present findings indicate that aminoglycoside antibiotics interfere with Ca2+-linked events leading to activation of the contractile mechanism of vascular smooth muscle. These in vitro findings may partially explain the occurrence of in vivo cardiovascular depression that has occasionally been observed after the administration of chemically related antimicrobial agents.Severe hypotensive episodes have been observed occasionally in man (3,9,24,25) and repeatedly in experimental animals (3,4,18,20,21) after the administration of aminoglycoside antibiotics (neomycin-streptomycin group). Although the mechanism(s) involved in this adverse side effect has not been completely resolved, recent studies suggest that these agents may alter peripheral vascular smooth muscle contractility.…”

mentioning

confidence: 99%

“…Severe hypotensive episodes have been observed occasionally in man (3,9,24,25) and repeatedly in experimental animals (3,4,18,20,21) after the administration of aminoglycoside antibiotics (neomycin-streptomycin group). Although the mechanism(s) involved in this adverse side effect has not been completely resolved, recent studies suggest that these agents may alter peripheral vascular smooth muscle contractility.…”

mentioning

confidence: 99%

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Alteration of Contractile Function and Calcium Ion Movements in Vascular Smooth Muscle by Gentamicin and Other Aminoglycoside Antibiotics

Adams

Goodman

Weiss

1974

Antimicrob Agents Chemother

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Experiments were conducted to examine the effects of certain aminoglycoside antibiotics on contractile responses.and related calcium ion (Ca2+) movements in isolated vascular smooth muscle. Gentamicin, kanamycin, and streptomycin decreased contractile responses produced by norepinephrine, histamine, and high K+ in rabbit aortic strips. The inhibitory action of these antibiotics on mechanical function was more pronounced when the Ca2+ concentration of the bathing solution was decreased from 1.5 mM (normal Ca2+ solution) to 0.05 mM (low Ca2+ solution). The uptake of radiocalcium ("'Ca) into the isolated media-intimal layer of rabbit aortae was decreased in a maintained manner by each antibiotic. With gentamicin, the inhibitory effect on 4"Ca uptake was shown to be dependent upon the concentration of gentamicin employed and to be more evident in a 0.1 mM Ca2+ solution than in a normal Ca2+ solution. In addition, the rate of 4"Ca efflux from the rabbit aortic media-intimal layer was increased in a sustained manner by gentamicin, streptomycin, and kanamycin. Furthermore, contractile responses induced by high K+ and norepinephrine in canine carotid arterial strips were inhibited by gentamicin. Present findings indicate that aminoglycoside antibiotics interfere with Ca2+-linked events leading to activation of the contractile mechanism of vascular smooth muscle. These in vitro findings may partially explain the occurrence of in vivo cardiovascular depression that has occasionally been observed after the administration of chemically related antimicrobial agents.Severe hypotensive episodes have been observed occasionally in man (3,9,24,25) and repeatedly in experimental animals (3,4,18,20,21) after the administration of aminoglycoside antibiotics (neomycin-streptomycin group). Although the mechanism(s) involved in this adverse side effect has not been completely resolved, recent studies suggest that these agents may alter peripheral vascular smooth muscle contractility. In the constant flow-rate perfused hind-limb preparation of thf dog, Cohen et al.(3) observed that the intraarterial administration of streptomycin and kanamycin decreased hind-limb vascular resistance. Evidence of streptomycin-induced dilatation of the renal vasculature was obtained in the in situ perfused canine kidney by Wolf and Wigton (30). The pharmacologic action involved in this peripheral vasomotor effect has not been determined, but several reports have associated this group of antibiotics with alteration of calcium ion (Ca2+) function in certain mammalian organ systems.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Alteration of Contractile Function and Calcium Ion Movements in Vascular Smooth Muscle by Gentamicin and Other Aminoglycoside Antibiotics

Adams

Goodman

Weiss

1974

Antimicrob Agents Chemother

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“…An anti-curare effect of ionic calcium was reported by del Castillo and Stark (1952). It is also known that calcium effectively antagonizes the myoneural blocking action of an excess of magnesium (del Castillo and Engbaek, 1954) and the neuromuscular block resulting from administration of such antibiotics as streptomycin, neomycin and kanamycin (Brazil and Corrado, 1957;Brazil, Corrado and Berti, 1959;Corrado, Ramos and DeEscobar, 1959;Jindal and Despande, 1960;Pandey, Kumar and Badola, 1964).…”

mentioning

confidence: 99%